Results 71 to 80 of about 108,558 (304)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Experimental investigation of O2 diffusion and entrapment in interstellar amorphous solid water

Astronomy & Astrophysics
Context. Interstellar ices are mainly composed of amorphous solid water (ASW) containing small amounts of hypervolatiles, such as O2, whose diffusion-limited reactions play a key role in space chemistry.
Coulaud L., Santos J. C., Chuang K.-J.
doaj   +1 more source

Chemical evolution of turbulent protoplanetary disks and the Solar nebula

, 2011
This is the second paper in a series where we study the influence of transport processes on the chemical evolution of protoplanetary disks. Our analysis is based on a flared alpha-model of the DM Tau system, coupled to a large gas-grain chemical network.
Aikawa, Aikawa, Aikawa, Aikawa, Aikawa, Andrews, Bauer, Bergin, Bergin, Bethell, Biver, Bockelée-Morvan, Boss, Bradley, Brownlee, Calvet, Cant, Cazaux, Chapillon, Crabtree, D'Alessio, d'Hendecourt, D. Semenov, D. Wiebe, Dickens, Duschl, Dutrey, Dutrey, Dutrey, Finocchi, Fogel, Fukagawa, Gail, Garrod, Glassgold, Glassgold, Glassgold, Glassgold, Gorti, Gorti, Greenberg, Greenberg, Harada, Hasegawa, Heinzeller, Henning, Hersant, Hirose, Hughes, Juhász, Jørgensen, Kalenskii, Kamp, Katz, Kim, Lahuis, Lee, Lee, Lee, Leger, Lynden-Bell, Mazzitelli, Meijerink, Najita, Najita, Pagani, Pascucci, Perez-Becker, Pierce, Pontoppidan, Pontoppidan, Pontoppidan, Prinn, Qi, Qi, Sakai, Salyk, Salyk, Sarrasin, Savin, Schräpler, Semenov, Semenov, Shakura, Shalabiea, Simon, Terada, Turner, Turner, Vasyunin, Vasyunin, Vasyunin, Wakelam, Wakelam, Walsh, Willacy, Willacy, Wolf, Wooden, Wooden, Woods, Woods, Zasowski, Öberg   +103 more
core   +1 more source

The composition of the protosolar disk and the formation conditions for comets [PDF]

, 2015
Conditions in the protosolar nebula have left their mark in the composition of cometary volatiles, thought to be some of the most pristine material in the solar system.
A. Dutrey, A. Kouchi, A.E. Glassgold, A.G.G.M. Tielens, A.I. Vasyunin, A.L. Cochran, A.N. Heays, A.Z. Dolginov, B. Silvi, B.P. Bonev, B.P. Bonev, B.P. Bonev, C. Alexander, C. Ceccarelli, C. Ceccarelli, C. Ceccarelli, C. Dominik, C. Qi, C. Qi, C. Qi, C. Qi, C. Salyk, C. Tornow, C. Tornow, C. Tornow, C. Walsh, C. Walsh, C.E. Woodward, C.P. Dullemond, D. Bockelée-Morvan, D. Bockelée-Morvan, D. Bockelée-Morvan, D. Bockelée-Morvan, D. Bockelée-Morvan, D. Gautier, D. Harsono, D. Heinzeller, D. Hutsemékers, D. Kozlowski, D. Semenov, D. Semenov, D.C. Lis, E. Gibb, E. Herbst, E. Jehin, E. Lellouch, E. Roueff, E. S. Wirström, E. Zicler, E.D. Young, E.K. Jessberger, E.L. Gibb, E.S. Wirström, E.S. Wirström, F. Hersant, F. Pauzat, F.C. Adams, F.J. Ciesla, F.J. Ciesla, G. Buntkowsky, G. Bussolin, G. Cremonese, G. Kresse, G. Kresse, G. Notesco, G.J. Flynn, G.J. Villanueva, G.L. Villanueva, G.S. Mathews, H. Kawakita, H. Kawakita, H. Kawakita, H. Kawakita, H. Yurimoto, H. Yurimoto, I. Gregorio-Monsalvo de, I. Pater de, I. Pater de, J. Crovisier, J. Crovisier, J. Crovisier, J. Crovisier, J. Crovisier, J. Schönke, J.-E. Lee, J.C. Mottram, J.E. Heidenreich III, J.F. Hawley, J.F. Hawley, J.I. Lunine, J.J. Kavelaars, J.K.J. Fogel, J.P. Perdew, J.R. Lyons, J.R. Najita, J.S. Carr, J.S. Lewis, J.S. Mathis, K. Altwegg, K. France, K. Hashimoto, K. Nagashima, K. Saigo, K. Willacy, K. Willacy, K. Willacy, K. Willacy, K. Willacy, K. Willacy, K.D. McKeegan, K.I. Öberg, K.M. Chick, K.M. Pontoppidan, K.M. Pontoppidan, K.M. Pontoppidan, K.M. Pontoppidan, K.Y. Furuya, L. Pagani, L. Paganini, L. Podio, L.I. Cleeves, L.I. Cleeves, L.I. Cleeves, L.R. Nittler, M. Ali-Dib, M. Ali-Dib, M. Asplund, M. Calatayud, M. Doronin, M. Hassig, M. Ilgner, M. Ilgner, M. Ilgner, M. Pettini, M.A. DiSanti, M.F. A’Hearn, M.J. Mumma, M.J. Mumma, M.J. Mumma, M.R. Hogerheijde, M.V. Persson, N. Biver, N. Dello Russo, N. Dello Russo, N. Dello Russo, N. Fray, N. Iro, N. Watanabe, N.J. Turner, N.J. Turner, N.J. Turner, O. Mousis, O. Mousis, O. Mousis, O. Mousis, O. Mousis, O. Mousis, O. Mousis, O. Mousis, O. Mousis, O. Mousis, O. Mousis, P. Caselli, P. D’Alessio, P. Eberhardt, P. Eberhardt, P. Gast, P. Hartogh, P. Theulé, P.M. Woods, P.M. Woods, R. Hueso, R. Llusar, R. Meier, R. Meier, R. Visser, R. Visser, R. Visser, R.N. Clayton, R.N. Clayton, S. B. Charnley, S. Casassa, S. Casassa, S. Grimme, S. Gulkis, S. Inutsuka, S. N. Milam, S. Wyckoff, S.A. Balbus, S.B. Charnley, S.B. Charnley, S.B. Charnley, S.B. Charnley, S.B. Charnley, S.D. Rodgers, S.E. Dodson-Robinson, T. Albertsson, T. Albertsson, T. Albertsson, T. Bredichin, T. Hama, T. Lee, T. Owen, T.J. Millar, Th. Henning, U. Marboeuf, U. Marboeuf, U. Marboeuf, V. Akimkin, V. Taquet, V. Taquet, V. Wakelam, V. Zubko, W.-H. Ip, W.D. Langer, W.M. Irvine, Y. Aikawa, Y. Aikawa, Y. Aikawa, Y. Aikawa, Y. Aikawa, Y. Aikawa, Y. Alibert, Y. Alibert, Y. Ellinger, Y. Ellinger, Y. Shinnaka, Y.L. Radeva   +227 more
core   +3 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

UV photodesorption of methanol in pure and CO-rich ices: desorption rates of the intact molecule and of the photofragments [PDF]

, 2016
Wavelength dependent photodesorption rates have been determined using synchrotron radiation, for condensed pure and mixed methanol ice in the 7 -- 14 eV range. The VUV photodesorption of intact methanol molecules from pure methanol ices is found to be of
Bertin, Mathieu, Doronin, Mikhail, Fillion, Jean-Hugues, Jeseck, Pascal, Ligterink, Niels, Linnartz, Harold, Litgerink, Niels, Michaut, Xavier, Philippe, Laurent, Romanzin, Claire   +9 more
core   +5 more sources

Microbial abundance in surface ice on the Greenland Ice Sheet [PDF]

Frontiers in Microbiology, 2015
Measuring microbial abundance in glacier ice and identifying its controls is essential for a better understanding and quantification of biogeochemical processes in glacial ecosystems. However, cell enumeration of glacier ice samples is challenging due to typically low cell numbers and the presence of interfering mineral particles. We quantified for the
Marek eStibal, Marek eStibal, Marek eStibal, Erkin eGözdereliler, Erkin eGözdereliler, Karen A. Cameron, Karen A. Cameron, Jason E. Box, Ian T. Stevens, Jarishma K. Gokul, Morten eSchostag, Jakub D. Zarsky, Jakub D. Zarsky, Arwyn eEdwards, Tristram D.L. Irvine-Fynn, Carsten Suhr Jacobsen, Carsten Suhr Jacobsen, Carsten Suhr Jacobsen   +17 more
openaire   +6 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Detection of CO in Triton's atmosphere and the nature of surface-atmosphere interactions

, 2010
Triton possesses a thin atmosphere, primarily composed of nitrogen, sustained by the sublimation of surface ices. The goal is to determine the composition of Triton's atmosphere and to constrain the nature of surface-atmosphere interactions.
de Bergh, C., Ferron, S., Käufl, H. -U., Lellouch, E., Sicardy, B.   +4 more
core   +2 more sources