Results 211 to 220 of about 122,799 (260)
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Comparison of surface modification and solid dispersion techniques for drug dissolution
International Journal of Pharmaceutics, 2000Surface modification and solid dispersion formulations using hydrophilic excipients can significantly alter the dissolution behaviour of hydrophobic drug materials. The effect of these techniques used individually and in combination on the dissolution properties of the hydrophobic drug, phenylbutazone (PB), are compared. PB was treated with a poloxamer,
G Rowley
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A novel surface-attached carvedilol solid dispersion with enhanced solubility and dissolution
Archives of Pharmacal Research, 2013A novel surface-attached, spray-dried solid dispersion containing poorly water-soluble carvedilol (CV) without any change in the crystallinity was prepared using water, polyvinylpyrrolidone (PVP K30) and Tween 80. The solid dispersion was optimized by investigating the effects of the weight ratios of Tween 80/PVP K30 and carrier/drug on the aqueous ...
Nirmal Marasini +2 more
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Surface Solid Dispersion – A Review
International Journal of Pharmaceutical Sciences and Nanotechnology, 2013Preparation of an effective formulation of poorly water-soluble drugs is a key challenge in pharmaceutical technology. Dissolution rate and solubility are the rate- limiting steps for increasing the bioavailability of poorly water‐soluble drugs.
Sadhna Khatry, Neha Sood, Sandeep Arora
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Surface-attached Solid Dispersion
Journal of Pharmaceutical Investigation, 2010ABSTRACT − A novel surface-attached solid dispersion is designed to improve the solubility and oral bioavailability ofpoorly water-soluble drugs without crystalline change. Accordingly, it draws increasing interest because of excellent stabilityand no pollution for accomplishing enhanced solubility and bioavailability, which have recently been ...
Young-Joon Park +6 more
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The effect of processing on the surface physical stability of amorphous solid dispersions
European Journal of Pharmaceutics and Biopharmaceutics, 2014The focus of this study was to investigate the effect of processing on the surface crystallization of amorphous molecular dispersions and gain insight into the mechanisms underpinning this effect. The model systems, amorphous molecular dispersions of felodipine-EUDRAGIT® E PO, were processed both using spin coating (an ultra-fast solvent evaporation ...
Qi, Sheng +5 more
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Drug Development and Industrial Pharmacy, 1988
AbstractBy grinding, chloramphenicol stearate Form III turns into Form I: then this form tends to become amorphous. So the grinding of both forms produces a “physically activated” form (FI*) with low crystallinity degree and high CAP availability.
FORNI, Flavio +4 more
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AbstractBy grinding, chloramphenicol stearate Form III turns into Form I: then this form tends to become amorphous. So the grinding of both forms produces a “physically activated” form (FI*) with low crystallinity degree and high CAP availability.
FORNI, Flavio +4 more
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Surfaces and Interfaces, 2020
Abstract The surface of dispersed systems in which the dispersion medium is solid presents a complex morphology that depends on the processes associated with the formation of the solid phase and the dispersion grade of the dispersed phase. Considering that this morphology is a manifestation of the stochastic processes in the disperse phase, a ...
Edgardo J. Suarez-Dominguez +4 more
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Abstract The surface of dispersed systems in which the dispersion medium is solid presents a complex morphology that depends on the processes associated with the formation of the solid phase and the dispersion grade of the dispersed phase. Considering that this morphology is a manifestation of the stochastic processes in the disperse phase, a ...
Edgardo J. Suarez-Dominguez +4 more
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Surface Tracking of Curcumin Amorphous Solid Dispersions Formulated by Binary Polymers
Journal of Pharmaceutical Sciences, 2020Herein, curcumin amorphous solid dispersions (Cur ASDs) were prepared using binary polymers (Eudragit EPO with polyvinylpyrrolidone K30 [EuD-PVP], Eudragit EPO with hydroxypropyl methylcellulose E50 [EuD-HPMC]) as excipient, and surface tracking of Cur ASDs was mainly addressed.
Na, Fan, Tong, Lu, Jing, Li
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Exact surface-plasmon dispersion relation for spatially dispersive solid with an abrupt surface
Vacuum, 1997Abstract The exact surface-plasmon dispersion relation for a semi-infinite medium with an abrupt surface and an arbitrary wave-vector and frequency dependent dielectric function ϵ(q,ω) is obtained. The result is applied to the models with hydrodynamic and Lindhard dielectric functions and the comparison with other theories and the experiment is ...
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Surface composition and contact angle relationships for differently prepared solid dispersions
European Journal of Pharmaceutics and Biopharmaceutics, 2008Solid dispersions are promising drug delivery forms which offer the possibility to disperse a hydrophobic drug in a hydrophilic matrix and thereby improve the dissolution behavior and the bioavailability of the drug. One important aspect and a prerequisite in understanding the drug dissolution mechanism from solid dispersions is a better analytical ...
Carina, Dahlberg +2 more
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