Results 51 to 60 of about 6,308,794 (242)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

A solid one-dimensional microstructured optical fiber with high nonlinearity and low dispersion at 1.55 microns

, 2009
We report on the fabrication of a solid one-dimensional microstructured fiber with high nonlinearity and low dispersion at 1.55µm. A four-wave-mixing based tunable wavelength-conversion scheme was experimentally demonstrated in just 1.5m of this ...
Camerlingo, A., Horak, P., Petropoulos, P., Parmigiani, F., Richardson, D.J., Poletti, F., Loh, W.H., Feng, X.   +7 more
core   +1 more source

Investigation of the Interaction Mechanism of Solid Particles under Shock Waves

Shock and Vibration, 2022
To deeply understand the interaction mechanism between the two phases, both shock wave experiments and computational fluid dynamics (CFD) simulations are carried out to study the propagation of shock waves and the dispersion process of solid quartz sand ...
Xu Peng, Shunyao Wang, Guoning Rao, Bin Li, Wanghua Chen   +4 more
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Stereolithography 3D printing gyroid triply periodic minimal surface vitrified bond diamond grinding wheel

Scientific Reports
The pores of vitrified bond diamond grinding wheel play a key role in the grinding process. However, uneven pore distribution and low porosity affect the grinding performance of the wheel significantly.
Zhaoqi Chen, Kehan Li, Ping Han, Yuetang Pan, Guoju Bai, Zijing Xia, Na Xiao, Pengyu Wang   +7 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Development of hollow-core photonic bandgap fibres free of surface modes

, 2009
Conventional optical fibres can only guide light in a high refractive index core by total internal reflection. By using total internal reflections it is not possible to guide light in an air core.
Amezcua-Correa, Rodrigo
core   +1 more source

Development of ternary solid dispersions with hydrophilic polymer and surface adsorbent for improving dissolution rate of carbamazepine

Saudi Pharmaceutical Journal, 2018
In this study solid dispersions of carbamazepine in the hydrophilic Kollidon® VA64 polymer, adsorbed onto Neusilin® UFL2 adsorption carrier have been employed to improve carbamazepine dissolution rate.
Tanja Vojinović, Djordje Medarević, Edina Vranić, Zorica Potpara, Marko Krstić, Jelena Djuriš, Svetlana Ibrić   +6 more
doaj   +1 more source

Pharmaceutical technologies for improving drug loading in the formulation of solid dispersions [PDF]

, 2013
textIt is estimated that 90% of new chemical entities in development pipelines exhibit poor aqueous solubility. For compounds not limited by biological membrane permeability, this poor aqueous solubility is the limiting factor in bioavailability ...
O'Donnell, Kevin Patrick
core