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Surfactant metabolism in surfactant protein A-deficient mice
American Journal of Physiology-Lung Cellular and Molecular Physiology, 1997In the present study we asked if surfactant metabolism was altered in surfactant protein (SP) A-deficient mice in vivo. Although previous studies in vitro demonstrated that SP-A modulates surfactant secretion and reuptake by type II cells, mice made SP-A deficient by homologous recombination grow and reproduce normally and have normal lung function ...
M, Ikegami +4 more
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Polymer–surfactant and protein–surfactant interactions
Journal of Colloid and Interface Science, 2005The phase behavior and some physicochemical properties of homopolymers (HP) and hydrophobically modified (HMP) polymers, as well as of polyelectrolytes (PE) and proteins (PR), in the presence of aqueous surfactants, or their mixtures, are discussed.
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Surfactant-Protein Interactions
2002To retain biological activity, proteins generally must be maintained in a specific, three-dimensional conformation. This conformation is only marginally stable, and thus relatively minor perturbing forces can disrupt protein structure, causing loss of biological activity, as well as formation of non-native protein aggregates.
Theodore W, Randolph, LaToya S, Jones
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Archives of Biochemistry and Biophysics, 1996
Surfactant protein A (SP-A) is an abundant lipoprotein component of pulmonary surfactant that plays multiple roles in surfactant homeostasis within the lung. A simple and rapid purification procedure for SP-A is described. Purified surfactant is washed by centrifugation with Ca2+ containing buffer to remove residual soluble proteins. Following the Ca2+
A, Suwabe, R J, Mason, D R, Voelker
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Surfactant protein A (SP-A) is an abundant lipoprotein component of pulmonary surfactant that plays multiple roles in surfactant homeostasis within the lung. A simple and rapid purification procedure for SP-A is described. Purified surfactant is washed by centrifugation with Ca2+ containing buffer to remove residual soluble proteins. Following the Ca2+
A, Suwabe, R J, Mason, D R, Voelker
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Biochemical Society Transactions, 1994
30. Erdei, A. and Reid, K. B. M. (1989) Behring Inst. Mitt. 84,216-219 31. Malhotra, R., Thiel, S., Reid, K. B. M. and Sim, R. B. (1990) J. Exp. Med. 172,955-959 32. Malhotra, R.. Haurum, J.? Thiel, S. and Sim, R. B. (1 992) Eur. J. Immunol. 22,14371445 33. Guan, E., Burgess, W. H., Robinson, S. I+ Goodman, E. B., McTigue, K. H. and Tenner, A. J. (1991)
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30. Erdei, A. and Reid, K. B. M. (1989) Behring Inst. Mitt. 84,216-219 31. Malhotra, R., Thiel, S., Reid, K. B. M. and Sim, R. B. (1990) J. Exp. Med. 172,955-959 32. Malhotra, R.. Haurum, J.? Thiel, S. and Sim, R. B. (1 992) Eur. J. Immunol. 22,14371445 33. Guan, E., Burgess, W. H., Robinson, S. I+ Goodman, E. B., McTigue, K. H. and Tenner, A. J. (1991)
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Functional Mapping of Surfactant Protein A
Fetal and Pediatric Pathology, 2001Surfactant protein A (SP-A) is a highly ordered, oligomeric glycoprotein that is secreted into the airspaces of the lung by alveolar type II cells and Clara cells of the pulmonary epithelium. Although research has shown that SP-A is both a calcium-dependent phospholipid-binding protein that affects surfactant structure and function and a lectin that ...
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Genetic Disorders of Surfactant Proteins
Neonatology, 2007Inherited disorders of pulmonary surfactant-associated proteins are rare but provide important insights into unique mechanisms of surfactant dysfunction. Recessive loss-of-function mutations in the surfactant protein-B and the ATP-binding cassette family member A3 (ABCA3) genes present as lethal surfactant deficiency in the newborn, whereas other ...
Aaron, Hamvas +2 more
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The American Journal of the Medical Sciences, 2001
Surfactant protein B (SP-B) deficiency is a disorder of surfactant function with complete or transient absence of SP-B in term neonates. SP-B, 1 of 4 described surfactant-associated proteins, plays a key role in surfactant metabolism, particularly in intracellular packaging of surfactant components, formation of tubular myelin, and the presentation of ...
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Surfactant protein B (SP-B) deficiency is a disorder of surfactant function with complete or transient absence of SP-B in term neonates. SP-B, 1 of 4 described surfactant-associated proteins, plays a key role in surfactant metabolism, particularly in intracellular packaging of surfactant components, formation of tubular myelin, and the presentation of ...
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Self-Aggregation of Surfactant Protein A
Biochemistry, 2000Environmental factors of physiological relevance such as pH, calcium, ionic strength, and temperature can affect the state of self-aggregation of surfactant protein A (SP-A). We have studied the secondary structure of different SP-A aggregates and analyzed their fluorescence characteristics.
M L, Ruano +4 more
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Synthetic Surfactant Protein Analogues
Neonatology, 1998Surfactant preparations for the treatment of respiratory distress syndrome (RDS) that contain phospholipids and small amounts of the two hydrophobic proteins, SP-B and SP-C, are presently obtained from animal lungs. Since structural information about SP-B and SP-C is available, it appears possible to design analogues that can replace the native ...
J, Johansson +5 more
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