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Hydrophobic Surfactant Proteins and Their Analogues
Neonatology, 2007Lung surfactant is a complex mixture of phospholipids and four surfactant-associated proteins (SP-A, SP-B, SP-C and SP-D). Its major function in the lung alveolus is to reduce surface tension at the air-water interface in the terminal airways by the formation of a surface-active film enriched in surfactant lipids, hence preventing cellular collapse ...
Frans J, Walther +4 more
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Surfactant proteins of the human larynx
Annals of Anatomy - Anatomischer Anzeiger, 2016Surfactant proteins (SPs) originally identified in lung tissue are important players in the innate immune system. Beyond this, they contribute to stability and rheology of gaseous or aqueous interphases. In the present study, we determined the expression and presence of SPs (A, B, C and D) in different areas of the human larynx.mRNA expression of SP-A,
M, Sheats +10 more
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The proteins of human lung surfactant
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1985Human pulmonary surfactant was purified from bronchoalveolar lavage of patients. The proteins present in surfactant were analyzed by SDS-polyacrylamide gel electrophoresis into serum and non-serum components. One non-serum surfactant protein (Mr = 43 000) was then identified in the 100 000 X g supernatant of a lung homogenate on the basis of ...
Hunt, A.N. +2 more
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American Journal of Respiratory Cell and Molecular Biology, 1991
.The lipid and protein components of surfactant are syn thesized and secreted by the alveolar type II epithelial cell. Newly secreted surfactant adsorbs to the alveolar air-liquid interface, where it spreads as a monomolecular film that serves to reduce surface tension during expiration.
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.The lipid and protein components of surfactant are syn thesized and secreted by the alveolar type II epithelial cell. Newly secreted surfactant adsorbs to the alveolar air-liquid interface, where it spreads as a monomolecular film that serves to reduce surface tension during expiration.
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Protein‐polysaccharide complexes as surfactants
Food / Nahrung, 1986AbstractA study has been made of surface pressure (π) and maximum shear stress (Ps) (at a constant shear rate) of decane‐water interface on which bovine serum albumin (BSA) and its complexes with dextran sulfate (DS) were adsorbed. The π values have been monitored by the WILHELMY plate technique.
A N, Gurov, P V, Nuss
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Immunoregulatory functions of surfactant proteins
Nature Reviews Immunology, 2005Because the lungs function as the body's gas-exchange organ, they are inevitably exposed to air that is contaminated with pathogens, allergens and pollutants. Host-defence mechanisms within the lungs must facilitate clearance of inhaled pathogens and particles while minimizing an inflammatory response that could damage the thin, delicate gas-exchanging
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Gemini surfactant-protein interactions
2008The interactions between bovine serum albumin (BSA) and gemini surfactants derived from cystine have been investigated and were compared with the conventional single-chain surfactant derived from cysteine. The influence of the stereochemistry of the gemini surfactant on its behavior toward BSA was also investigated, as well as the effects of pH and ...
Faustino, Celia M. C. +2 more
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The role of surfactant protein-A in sinusitis
Current Opinion in Allergy & Clinical Immunology, 2019Purpose of review Surfactant protein-A (SP-A) is a collectin protein expressed in airway epithelia that is critical in the modulation of both innate and adaptive immunity against inhaled pathogens. In this review, we highlight associations of altered SP-A function in asthma and chronic rhinosinusitis, and its potential role as ...
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Current Trends in Protein-Surfactant Interactions: A Review
Journal of Molecular Liquids, 2021Ramesh Chand Thakur +2 more
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