Results 31 to 40 of about 119,289,483 (303)

Surfactant Protein Profile of Pulmonary Surfactant in Premature Infants [PDF]

American Journal of Respiratory and Critical Care Medicine, 2003
Abstract Although premature infants are known to be deficient in pulmonary surfactant, there is limited information regarding surfactant protein (SP) composition. To assess the postnatal profile of SPs, tracheal aspirate samples were collected from 35 intubated infants of 23–31 weeks of gestation between 8 and 80 days of age.
Philip L, Ballard, Jeffrey D, Merrill, Rodolfo I, Godinez, Marye H, Godinez, William E, Truog, Roberta A, Ballard   +5 more
openaire   +2 more sources

AIDS patients have increased surfactant protein D but normal mannose binding lectin levels in lung fluid. [PDF]

, 2007
BACKGROUND: Surfactant protein D (SP-D) and Mannose Binding Lectin (MBL) are collectins that have opsonic and immunoregulatory functions, are found in lung fluid and interact with the human immunodeficiency virus (HIV).
Ed Zijlstra, Jambo Kondwani C, Zijlstra, Ed, Jambo, Kondwani C, Gordon, Stephen, French Neil, Kondwani C Jambo, Neil French, Stephen B Gordon, French, Neil, Gordon, Stephen B, Zijlstra Ed, Gordon Stephen B, Kondwani C Jambo, Jambo, Kondwani; id_orcid   +14 more
core   +2 more sources

Binding of pulmonary surfactant proteins to carbon nanotubes; potential for damage to lung immune defense mechanisms [PDF]

, 2007
Potential pulmonary toxicity of carbon nanotubes is a research area that has received considerable attention. Surfactant proteins A and D (SP-A and SP-D) are collectin proteins that are secreted by airway epithelial cells in the lung.
Vénien-Bryan, Catherine, Townsend, Paul, Green, Malcolm L. H., Flahaut, Emmanuel, Sim, Robert B., Salvador-Morales, Carolina, Vlandas, Alexis   +6 more
core   +1 more source

Development and assessment of the efficacy and safety of human lung-targeting liposomal methylprednisolone crosslinked with nanobody

Drug Delivery, 2021
Glucocorticoid (GC) hormone has been commonly used to treat systemic inflammation and immune disorders. However, the side effects associated with long-term use of high-dose GC hormone limit its clinical application seriously.
Dong Weng, Zhao-Fang Yin, Shan-Shan Chen, Xian He, Nan Li, Tao Chen, Hui Qiu, Meng-Meng Zhao, Qin Wu, Nian-Yu Zhou, Li-Qin Lu, Dan-Li Tang, Jia-Cui Song, Hui-Ping Li   +13 more
doaj   +1 more source

Surfactant-free purification of membrane protein complexes from bacteria: application to the staphylococcal penicillin-binding protein complex PBP2/PBP2a. [PDF]

, 2014
Surfactant-mediated removal of proteins from biomembranes invariably results in partial or complete loss of function and disassembly of multi-protein complexes. We determined the capacity of styrene-co-maleic acid (SMA) co-polymer to remove components of
Taylor, Peter W, Paulin, S, Roper, David I, Garcia-Lara, J, Roper, DI, Taylor, PW, Galley, Nicola F., Paulin, Sarah, Rosado, H, Foster, SJ, Taylor, Peter W., Dafforn, TR, Dafforn, Tim, Dafforn, Timothy R, Galley, Nicola F, Jamshad, Mohammed, Rosado, Helena, Foster, Simon J, Garcia-Lara, Jorge, Jamshad, M, Galley, NF, Foster, Simon J., Roper, David I.   +22 more
core   +1 more source

Surfactant protein A and surfactant protein D variation in pulmonary disease

Immunobiology, 2007
Surfactant proteins A (SP-A) and D (SP-D) have been implicated in pulmonary innate immunity. The proteins are host defense lectins, belonging to the collectin family which also includes mannan-binding lectin (MBL). SP-A and SP-D are pattern-recognition molecules with the lectin domains binding preferentially to sugars on a broad spectrum of pathogen ...
Sørensen, Grith Lykke, Husby, Steffen, Holmskov, Uffe   +2 more
openaire   +2 more sources

Effect of surfactant protein A on the physical properties and surface activity of KL4-surfactant

, 2007
SP-A, the major protein component of pulmonary surfactant, is absent in exogenous surfactants currently used in clinical practice. However, it is thought that therapeutic properties of natural surfactants improve after enrichment with SP-A. The objective
Johnson, Mark, Casals Carro, María Cristina, Cañadas Benito, Olga, Sánchez Barbero, Fernando, Sáenz, Alejandra, Bagatolli, Luís   +5 more
core   +2 more sources

Protein-surfactant interactions at solid surfaces

, 1995
Effects of surfactants on protein adsorption are reviewed. Differences between removal of preadsorbed proteins (elutability) and competitive adsorption are discussed and simple models are suggested.
Wahlgren, Marie C, Arnebrant, Thomas, Arnebrant, Thomas,, Wahlgren, Marie C,, Thomas Arnebrant, Marie C. Wahlgren, Lund University.   +6 more
core   +2 more sources

Determining suitable surfactant concentration ranges to avoid protein unfolding in pharmaceutical formulations using UV analysis

Heliyon, 2023
Protein stability is fundamental to maintain pharmaceutical efficacy in the nascent field of biologics. One particular property that is essential for therapeutic effect is retention of the folded 3-dimensional conformation, i.e.
Laura J. Waters, Joseph Whiteley, William Small, Steve Mellor   +3 more
doaj   +1 more source

Differential Impact of Co-expressed SP-A1/SP-A2 Protein on AM miRNome; Sex Differences

Frontiers in Immunology, 2019
In humans there are two surfactant protein A (SP-A) functional genes SFTPA1 and SFTPA2 encoding innate immune molecules, SP-A1 and SP-A2, respectively, with numerous genetic variants each.
Nithyananda Thorenoor, Yuka Imamura Kawasawa, Chintan K. Gandhi, Xuesheng Zhang, Joanna Floros, Joanna Floros   +5 more
doaj   +1 more source