Results 11 to 20 of about 119,289,483 (303)

The detection of surfactant proteins A, B, C and D in the human brain and their regulation in cerebral infarction, autoimmune conditions and infections of the CNS. [PDF]

PLoS ONE, 2013
Surfactant proteins (SP) have been studied intensively in the respiratory system. Surfactant protein A and surfactant protein D are proteins belonging to the family of collectins each playing a major role in the innate immune system.
Stefan Schob, Martin Schicht, Saadettin Sel, Dankwart Stiller, Alexander S Kekulé, Friedrich Paulsen, Erik Maronde, Lars Bräuer   +7 more
doaj   +3 more sources

Disaturated-phosphatidylcholine and Surfactant protein-B turnover in human acute lung injury and in control patients [PDF]

Respiratory Research, 2011
Background Patients with Adult Respiratory Distress Syndrome (ARDS) and Acute Lung Injury (ALI) have low concentrations of disaturated-phosphatidylcholine and surfactant protein-B in bronchoalveolar lavage fluid.
Rizzi Sabina, Massara Lorenza, Rossi Sandra, Vedovelli Luca, Ori Carlo, Baritussio Aldo, Simonato Manuela, Carnielli Virgilio P, Cogo Paola E   +8 more
doaj   +3 more sources

Surfactant protein A and surfactant protein D in health and disease [PDF]

American Journal of Physiology-Lung Cellular and Molecular Physiology, 1998
Surfactant protein (SP) A and SP-D are collagenous glycoproteins with multiple functions in the lung. Both of these proteins are calcium-dependent lectins and are structurally similar to mannose-binding protein and bovine conglutinin. Both form polyvalent multimeric structures for interactions with pathogens, cells, or other molecules.
R J, Mason, K, Greene, D R, Voelker
openaire   +2 more sources

The proteins of the surfactant system [PDF]

European Respiratory Journal, 1994
The structural and functional integrity of pulmonary surfactant depends on several specific proteins. Two of these, SP-A and SP-D, are large and water-soluble, while SP-B and SP-C are small and very hydrophobic. SP-A is an 18-mer of 26 kDa polypeptide chains and contains N-linked oligosaccharides.
J, Johansson, T, Curstedt, B, Robertson
openaire   +2 more sources

Sex-Specific Regulation of Gene Expression Networks by Surfactant Protein A (SP-A) Variants in Alveolar Macrophages in Response to Klebsiella pneumoniae

Frontiers in Immunology, 2020
Surfactant protein A (SP-A) in addition to its surfactant-related functions interacts with alveolar macrophages (AM), the guardian cells of innate immunity in the lungs, and regulates many of its functions under basal condition and in response to various
Nithyananda Thorenoor, Nithyananda Thorenoor, Yuka Imamura Kawasawa, Chintan K. Gandhi, Joanna Floros, Joanna Floros   +5 more
doaj   +1 more source

Surfactant Proteins A/D–CD14 on Alveolar Macrophages Is a Common Pathway Associated With Phagocytosis of Nanomaterials and Cytokine Production

Frontiers in Immunology, 2021
Alveolar macrophages are responsible for clearance of airborne dust and pathogens. How they recognize and phagocytose a variety of engineered nanomaterials (ENMs) with different properties is an important issue for safety assessment of ENMs.
Qiqi Wang, Qiqi Wang, Qiong Wang, Ziyue Zhao, Jingbo Fan, Linghan Qin, David B. Alexander, Hiroyuki Tsuda, Dahai Zhao, Jiegou Xu, Jiegou Xu   +10 more
doaj   +1 more source

Small Peptide Derivatives Within the Carbohydrate Recognition Domain of SP-A2 Modulate Asthma Outcomes in Mouse Models and Human Cells

Frontiers in Immunology, 2022
Surfactant Protein-A (SP-A) is an innate immune modulator that regulates a variety of pulmonary host defense functions. We have shown that SP-A is dysfunctional in asthma, which could be partly due to genetic heterogeneity.
Dave Francisco, Dave Francisco, Ying Wang, Ying Wang, Craig Marshall, Michelle Conway, Kenneth J. Addison, Dean Billheimer, Hiroki Kimura, Hiroki Kimura, Mari Numata, Hong W. Chu, Dennis R. Voelker, Monica Kraft, Monica Kraft, Julie G. Ledford, Julie G. Ledford   +16 more
doaj   +1 more source

Exploring protein–protein interactions and oligomerization state of pulmonary surfactant protein C (SP‐C) through FRET and fluorescence self‐quenching [PDF]

, 2023
Acknowledgments: FPI fellowship from the Spanish Ministry of Science and Innovation. COMPETE2020-Operational Program for Competitiveness and Internationalization, funding by the European Regional Development Fund.
Prieto, Manuel, Coutinho, Ana, Pérez Gil, Jesús, Morán Lalangui, Juranny Michelle, García Álvarez, María Begoña, Fedorov, Alexander, Loura, Luís M. S., Morán-Lalangui, Mishelle, Loura, Luís M S, Pérez-Gil, Jesús, García‐Álvarez, Begoña, García-Álvarez, Begoña, Morán‐Lalangui, Mishelle, Pérez‐Gil, Jesús   +13 more
core   +1 more source

Potential biochemical markers of chronic bronchitis and bronchial asthma. Current state of the problem

Сибирский научный медицинский журнал, 2020
The literature review, according to recent publications, systematizes modern ideas about new biochemical markers of bronchopulmonary pathology, namely chronic obstructive pulmonary disease, chronic bronchitis and bronchial asthma.
E. A. Kurtukov, Yu. I. Ragino
doaj   +1 more source

Surfactant protein A alters endosomal trafficking of influenza A virus in macrophages

Frontiers in Immunology, 2023
Influenza A virus infection (IAV) often leads to acute lung injury that impairs breathing and can lead to death, with disproportionate mortality in children and the elderly. Surfactant Protein A (SP-A) is a calcium-dependent opsonin that binds a variety
Eric Yau, Linlin Yang, Yan Chen, Todd M. Umstead, Hannah Atkins, Zoe E. Katz, Jonathan W. Yewdell, Chintan K. Gandhi, E. Scott Halstead, Zissis C. Chroneos, Zissis C. Chroneos   +10 more
doaj   +1 more source