Results 241 to 250 of about 17,566,312 (293)

Deep Learning‐Driven Discovery and Engineering of an Efficient PETase for Depolymerization and Detoxification of PET Microplastics Under Physiological Conditions

Advanced Science, EarlyView.
A deep learning–driven pipeline mining 246 million protein sequences uncovers AhPETase, an evolutionarily distinct PET hydrolase. Engineered variant AhPETaseM1 degrades post‐consumer PET microplastics under physiological conditions and reverses microplasticinduced cytotoxicity in human lung and colon cells, establishing enzymatic microplastic ...
Yuxuan Wang, Shijie He, Yuheng Chang, Sheng Mao, Jianan Canal Li, Binbin Chen, Hongxun Gao, Mingchun Xu, Chenxu Liu, Yajie Wang   +9 more
wiley   +1 more source

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

Magnetoelectric BaTiO3/CoFe2O4 Thin‐Film Meshes for Neuronal Differentiation

Advanced Science, EarlyView.
We engineer an epitaxial BaTiO3/CoFe2O4 magnetoelectric mesh that overcomes boundary‐induced mechanical clamping. Progressively reducing the mechanical constraint, from substrate‐clamped to PDMS‐transferred and ultimately freestanding, enhances magnetic‐to‐electric transduction and strengthens magnetoelectric coupling.
Mathieu Mirjolet, Hao Ye, Abderrahim Lahlahi Attalhaoui, Donghoon Kim, Vitaly Pustovalov, Elric Zhang, Marc Tudela‐Pi, Bastian Gebauer, Juan Bautista Carda Castelló, Anton Guimerà‐Brunet, Josep Puigmartí‐Luis, Xiang‐Zhong Chen, Minsoo Kim, Salvador Pané   +13 more
wiley   +1 more source

The CXCL5/CXCR2 Axis Attenuates Ferroptosis in Intrahepatic Cholangiocarcinoma Through the Positive Feedback Loop Between PTGS2 Transcriptional Activation and Neutrophil Recruitment

Advanced Science, EarlyView.
The CXCL5/CXCR2 axis directly inhibits ferroptosis in ICC cells by activating the NF‐κB/PTGS2 pathway. Meanwhile, the CXCL5/CXCR2 axis recruits N2 TANs, and the activated PTGS2 promotes the secretion of TNF‐α from the recruited N2 TANs via the CCL2/CCL7/CCR2 pathway, thereby activating the NF‐κB/PTGS2 axis and forming a positive feedback loop, which ...
Chanqi Ye, Kefeng Lin, Shuyao Yang, Yan Zhang, Wenli Gao, Jiaqi Chen, Ying Dong, Rui Bai, Yang Tian, Minghao Wang, Zhijun Yuan, Yuxiao Ma, Yuqin He, Ruyin Chen, Wenguang Fu, Qi Jiang, Qiong Li, Jian Ruan   +17 more
wiley   +1 more source

Iron‐Tannic Acid Hydrogel Mediated Mild Photothermal Therapy Combined With Ferroptosis Enhances Anti‐Tumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An injectable gelatin‐based tannic acid–iron hydrogel with mild photothermal therapy could not only induce immunogenic cell death, but also elicit ferroptosis of both tumor cells and tumor‐associated macrophages, resulting in DC maturation, T‐cell infiltration and down‐regulation of ferroptosis‐sensitive M2‐type TAMs levels.
Yuan Zhu, Xi Yu, Tao Wang, Wanyi Liu, Chang Lu, Jiani Zhong, Yujie He, Wei Li, Kunxi Zhang, Peihao Yin, Zeting Yuan   +10 more
wiley   +1 more source

Loss of LCN2 Function Ameliorates Glucocorticoid‐Induced Muscle Atrophy via Remodeling the Extracellular Matrix

Advanced Science, EarlyView.
Glucocorticoids transcriptionally activate LCN2 expression via GR nuclear translocation. Secreted LCN2 binds MMP9 to degrade skeletal muscle ECM collagen, blocks integrin‐mediated mechanotransduction, bidirectionally disrupts muscle protein homeostasis, and reveals a novel target for steroid‐induced muscle atrophy.
Hongwei Shi, Xiaojing Hao, Yi Yan, Fengyang Li, Yaru Zhang, Zixin Li, Wenjuan Xie, Jiayin Lu, Xiaomao Luo, Yanjun Dong, Haidong Wang, Juan Wang   +11 more
wiley   +1 more source

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In defense of the lung: surfactant protein A and surfactant protein D

Current Opinion in Pharmacology, 2006
The lung is repeatedly exposed to inhaled particles and pathogens that are cleared by the actions of a multi-component innate host defense system. The pulmonary collectins--surfactant proteins A (SP-A) and D (SP-D)--play important roles in innate host defense by binding and clearing invading microbes from the lung.
Paul S, Kingma, Jeffrey A, Whitsett
openaire   +2 more sources

Surfactant protein D is proatherogenic in mice

American Journal of Physiology-Heart and Circulatory Physiology, 2006
Surfactant protein D (SP-D) is an important innate immune defense molecule that mediates clearance of pathogens and modulates the inflammatory response. Moreover, SP-D is involved in lipid homeostasis, and pulmonary accumulation of phospholipids has previously been observed in SP-D-deficient ( Spd−/−) mice. Atherogenesis involves both inflammation and
Sorensen, G.L., Madsen, J., Kejling, K., Tornoe, I., Nielsen, O., Townsend, P., Poulain, F., Nielsen, C.H., Reid, K.B., Hawgood, S., Falk, E., Holmskov, U.   +11 more
openaire   +4 more sources

Surfactant proteins A and D

Biochemical Society Transactions, 1994
30. Erdei, A. and Reid, K. B. M. (1989) Behring Inst. Mitt. 84,216-219 31. Malhotra, R., Thiel, S., Reid, K. B. M. and Sim, R. B. (1990) J. Exp. Med. 172,955-959 32. Malhotra, R.. Haurum, J.? Thiel, S. and Sim, R. B. (1 992) Eur. J. Immunol. 22,14371445 33. Guan, E., Burgess, W. H., Robinson, S. I+ Goodman, E. B., McTigue, K. H. and Tenner, A. J. (1991)
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Surfactant Protein-D

2012
The collectins can be classed into two distinct group, with MBP and SP-A being hexamers and SP-D, conglutinin and collectin-43 (CL-43) being tetramers, with proteins in the latter group also having significantly larger dimensions with respect to the length of their collagen-like ‘stalks’ (Lu et al. 1993).
Rajesh K. Gupta, Anita Gupta
openaire   +1 more source