Results 251 to 260 of about 17,566,312 (293)
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American Journal of Respiratory Cell and Molecular Biology, 1991
.The lipid and protein components of surfactant are syn thesized and secreted by the alveolar type II epithelial cell. Newly secreted surfactant adsorbs to the alveolar air-liquid interface, where it spreads as a monomolecular film that serves to reduce surface tension during expiration.
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.The lipid and protein components of surfactant are syn thesized and secreted by the alveolar type II epithelial cell. Newly secreted surfactant adsorbs to the alveolar air-liquid interface, where it spreads as a monomolecular film that serves to reduce surface tension during expiration.
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The roles of surfactant proteins A and D in innate immunity
Immunological Reviews, 2000Summary: Research over the last decade on the surfactant proteins SP‐A and SP‐D suggests roles beyond surfactant lipid homeostasis, involving their participation in innate immune defence. SP‐A and SP‐D bind and agglutinate an impressive array of non‐self structures, ranging from bacteria and fungi to allergens and environmental inorganic substrates ...
P R, Lawson, K B, Reid
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Surfactant protein A and D in the reproductive tract of stallion
Theriogenology, 2006The presence of surface-active material in the lung alveolus has been known for several decades as being essential for normal lung function. The host defense and controlling inflammatory processes of the lung are the major functions of SP-A and SP-D.
Ata, Ayhan +2 more
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Surfactant Proteins A and D and Pulmonary Host Defense
Annual Review of Physiology, 2001▪ Abstract The lung collectins, SP-A and SP-D, are important components of the innate immune response to microbial challenge and participate in other aspects of immune and inflammatory regulation within the lung. Both proteins bind to surface structures expressed by a wide variety of microorganisms and have the capacity to modulate multiple leukocyte ...
E, Crouch, J R, Wright
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Surfactant protein D in atopic dermatitis and psoriasis
Experimental Dermatology, 2006Abstract: The collectin surfactant protein‐D (SP‐D) shows antimicrobial and immuno‐regulatory properties and has recently been detected in the basal layers of normal human skin. This molecule potentially plays an important role in inflammatory skin diseases and therefore SP‐D content and location was examined using immunohistochemistry on skin ...
Hohwy, Thomas +8 more
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Agglutination ofPseudomonas aeruginosa by Surfactant Protein D
Pediatric Pulmonology, 2005Surfactant protein D (SP-D) is part of the innate host defense system, and may bind and agglutinate invading microorganisms to enhance their removal. The ability of bronchoalveolar lavage (BAL) fluid to agglutinate bacteria and the relationship to its SP-D content are of interest and not yet known.
Matthias, Griese, Vitaliy, Starosta
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Surfactant proteins A and D in the genital tract of mares
Animal Reproduction Science, 2007The presence of surface-active material in the lung alveolus has been known for several decades as being essential for normal lung function. Surfactant is essential for reducing the surface tension at the alveolar air-liquid interface. Pulmonary surfactant is composed of 90% lipids and 10% proteins.
Gungor, Orsan +2 more
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Immunolocalization of Surfactant Protein A and D in Sinonasal Mucosa
American Journal of Rhinology, 2006Background Surfactant-associated proteins (SP) A and D are in the family of collectin proteins that play an integral part in the innate defense system. SP-A and SP-D expression and function are altered in a variety of inflammatory and infectious diseases of the lungs, such as asthma, allergies, and cystic ...
Bradford A, Woodworth +6 more
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Surfactant Protein-D and Surfactant Inhibit Endotoxin-Induced Pulmonary Inflammation
Chest, 2007Acute lung injury is a common cause of morbidity and mortality following pulmonary or systemic infections. Surfactant protein-D is a member of the collectin family of proteins, which play important roles in innate host defense of the lung. In this study, the effect of exogenous recombinant human SP-D (rhSP-D) on protection of the adult mouse lung from ...
Machiko, Ikegami +6 more
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Interactions of Surfactant Protein D with Fatty Acids
American Journal of Respiratory Cell and Molecular Biology, 2003Abstract Surfactant Protein D (SP-D) plays important roles in antimicrobial host defense, inflammatory and immune regulation, and pulmonary surfactant homeostasis. The best-characterized endogenous ligand is phosphatidylinositol; however, this lipid interaction at least in part involves the carbohydrate moiety.
Nihal S, DeSilva +2 more
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