Results 81 to 90 of about 8,905,690 (383)

Early Surgery for Traumatic Spinal Cord Injury: Where Are We Now? [PDF]

, 2020
Study Design: Narrative review. Objective: There is a strong biological rationale to perform early decompression after traumatic spinal cord injury (SCI).
Badhiwala, Jetan, Fehlings, Michael G., Harrop, James, Kwon, Brian K., Wilson, Jefferson R., Witiw, Christopher D.   +5 more
core   +1 more source

Premature mortality in refractory partial epilepsy: does surgical treatment make a difference? [PDF]

, 2010
Background: Epilepsy carries an increased risk of premature death. For some people with intractable focal epilepsy, surgery offers hope for a seizure-free life.
Bell, G.S., Dunacan, S.J., Harkness, W.F., McEvoy, A.W., Peacock, J.L., Sander, J.W., Scott, C.A., Sinha, S., Smith, S.J., Stephani, C., Tisi, J., Walker, M.C.   +11 more
core   +1 more source

A randomized trial of laparoscopic versus open surgery for rectal cancer.

New England Journal of Medicine, 2015
BACKGROUND Laparoscopic resection of colorectal cancer is widely used. However, robust evidence to conclude that laparoscopic surgery and open surgery have similar outcomes in rectal cancer is lacking.
H. Bonjer, C. Deijen, G. Abis, Miguel A. Cuesta, M. V. D. van der Pas, Elly S. M. de Lange-de Klerk, Antonio M. Lacy, W. A. Bemelman, J. Andersson, E. Angenete, J. Rosenberg, A. Fuerst, E. Haglind   +12 more
semanticscholar   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

SURGERY [PDF]

Annals of Surgery, 1908
n ...
openaire   +2 more sources

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

The Southampton Consensus Guidelines for Laparoscopic Liver Surgery: From Indication to Implementation

Annals of Surgery, 2017
Objective: The European Guidelines Meeting on Laparoscopic Liver Surgery was held in Southampton on February 10 and 11, 2017 with the aim of presenting and validating clinical practice guidelines for laparoscopic liver surgery.
M. Abu Hilal, L. Aldrighetti, I. Dagher, B. Edwin, R. Troisi, R. Alikhanov, S. Aroori, G. Belli, M. Besselink, J. Briceño, B. Gayet, M. D’Hondt, M. Lesurtel, K. Menon, P. Lodge, F. Rotellar, J. Santoyo, O. Scatton, O. Soubrane, R. Sutcliffe, R. V. van Dam, S. White, M. Halls, F. Cipriani, M. J. van der Poel, R. Ciria, L. Barkhatov, Yrene Gomez-Luque, Sira Ocana-Garcia, A. Cook, J. Buell, P. Clavien, C. Dervenis, G. Fusai, D. Geller, H. Lang, J. Primrose, M. Taylor, T. V. van Gulik, G. Wakabayashi, H. Asbun, D. Cherqui   +41 more
semanticscholar   +1 more source

Exploration and Validation of Key Genes and Immune Infiltration in Alcoholic Hepatitis

Journal of Inflammation Research
Yingna Mei,1 Yitao Zheng,2 Xingfen Zhang,1 Ting Hu,1 Xiaoqing Zheng,1 Cui Zhang,3 Qinzhi Deng1 1Department of Liver Disease, Ningbo No.2 Hospital, Ningbo, People’s Republic of China; 2Department of Pancreatic and Gastrointestinal Surgery Division, Ningbo
Mei Y, Zheng Y, Zhang X, Hu T, Zheng X, Zhang C, Deng Q   +6 more
doaj  

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source

Christian Albert Theodor Billroth, M.D., founding father of abdominal surgery (1829-1894). [PDF]

, 2012
In the 1800s, the field of surgery was in its infancy, somewhat primitive and embryonic. The technical nature of surgery was the basis for the dividing line between the disciplines of surgery and internal medicine. Sterilization was not a common practice.
Cowan, MD, Scott W., Fong, B.S., Zhi Ven, Lavu, MD, Harish, Rosato, MD, Ernest L., Yeo, MD, Charles J.   +4 more
core   +1 more source