Results 61 to 70 of about 133,335 (273)

Surrogate based design optimization of multi-band antenna

, 2021
In this work, design optimization process of a multiband antenna via the use of Artificial Neural Network (ANN) based surrogate model and meta-heuristic optimizers is studied. For this mean firstly, by using Latin-Hyper cube sampling method a data set based on 3D full wave EM simulator is generated to train an ANN based model.
Tarı, Özlem, Belen, Aysu, Mahouti, Peyman, Belen, Mehmet Ali   +3 more
openaire   +3 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Groundwater Pollution Source Identification via an Integrated Surrogate Model and Multiobjective Heuristic Optimization Algorithms

Water Resources Research
Simulation‐optimization methods are commonly used in groundwater pollution source identification. Traditional simulation‐optimization methods require multiple calls to the numerical model, which leads to a considerable computational burden.
Shengjie Hu, Zuorong Xu, Rui Zuo, Jingchao Liu   +3 more
doaj   +1 more source

Design Optimization Utilizing Dynamic Substructuring and Artificial Intelligence Techniques [PDF]

, 2008
In mechanical and structural systems, resonance may cause large strains and stresses which can lead to the failure of the system. Since it is often not possible to change the frequency content of the external load excitation, the phenomenon can only be ...
Akcay Perdahcioglu, D., Boer, A. de, Ellenbroek, M.H.M., Hoogt, P.J.M. van der   +3 more
core   +1 more source

A Derivative-Free Trust-Region Algorithm for Reliability-Based Optimization

, 2016
In this note, we present a derivative-free trust-region (TR) algorithm for reliability based optimization (RBO) problems. The proposed algorithm consists of solving a set of subproblems, in which simple surrogate models of the reliability constraints are
Gao, Tian, Li, Jinglai
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

An intelligent reliability-based design optimization of complex engineering structures using manifold learning-enhanced surrogate modeling

Advances in Mechanical Engineering
With the increasing integration of computer science and engineering optimization, the capabilities of advanced machine learning in data processing and surrogate modeling for complex simulations have provided a transformative development direction for ...
Hang Zhou, Yimin Shen, Song Chen, Xiaoping Jing   +3 more
doaj   +1 more source

Volute Optimization Based on Self-Adaption Kriging Surrogate Model

International Journal of Chemical Engineering, 2022
Optimizing the volute performance can effectively improve the efficiency of a centrifugal fan by changing the volute geometric parameter, so the self-adaption Kriging surrogate model is used to optimize the volute geometric parameter.
Fannian Meng, Ziqi Zhang, Liangwen Wang
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source