Results 81 to 90 of about 807,388 (293)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Generating surrogate data for time series with several simultaneously measured variables

open access: yes, 1994
We propose an extension to multivariate time series of the phase-randomized Fourier-transform algorithm for generating surrogate data. Such surrogate data sets must mimic not only the autocorrelations of each of the variables in the original data set ...
Prichard, Dean, Theiler, James
core   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Hierarchical Online Air Combat Maneuver Decision Making and Control Based on Surrogate-Assisted Differential Evolution Algorithm

open access: yesDrones
One-to-one within-visual-range air combat of unmanned combat aerial vehicles (UCAVs) requires fast, continuous, and accurate decision-making to achieve air combat victory.
Mulai Tan   +5 more
doaj   +1 more source

Calibrated Surrogate Losses for Classification with Label-Dependent Costs [PDF]

open access: yes, 2010
We present surrogate regret bounds for arbitrary surrogate losses in the context of binary classification with label-dependent costs. Such bounds relate a classifier's risk, assessed with respect to a surrogate loss, to its cost-sensitive classification ...
Scott, Clayton
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Deep LSTM Surrogates for MEMD: A Noise-Assisted Approach to EEG Intrinsic Mode Function Extraction

open access: yesInformation
In this paper, we propose a deep learning-based surrogate model for Multivariate Empirical Mode Decomposition (MEMD) using Long Short-Term Memory (LSTM) networks, aimed at efficiently extracting Intrinsic Mode Functions (IMFs) from ...
Pablo Andres Muñoz-Gutierrez   +2 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

A Gumbel-Based Selection Data-Driven Evolutionary Algorithm and Its Application to Chinese Text-Based Cheating Official Accounts Mining

open access: yesAlgorithms
Data-driven evolutionary algorithms (DDEAs) are essential computational intelligent methods for solving expensive optimization problems (EOPs). The management of surrogate models for fitness predictions, particularly the selection and integration of ...
Jiheng Yuan, Jian-Yu Li
doaj   +1 more source

Design Optimization Utilizing Dynamic Substructuring and Artificial Intelligence Techniques [PDF]

open access: yes, 2008
In mechanical and structural systems, resonance may cause large strains and stresses which can lead to the failure of the system. Since it is often not possible to change the frequency content of the external load excitation, the phenomenon can only be ...
Akcay Perdahcioglu, D.   +3 more
core   +1 more source

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