Results 231 to 240 of about 49,931 (273)

Azaporphyrinoid‐Based Photo‐ and Electroactive Architectures for Advanced Functional Materials

Advanced Materials, EarlyView.
A long‐standing collaboration between the Torres and Guldi groups has yielded diverse azaporphyrinoid‐based donor‐acceptor nanohybrids with promising applications in solar energy conversion. This conspectus highlights key molecular platforms and structure‐function relationships that govern light and charge management, supporting the rational design of ...
Jorge Labella, Kobra Azizi, Dirk M. Guldi, Tomás Torres   +3 more
wiley   +1 more source

The Evaluation of Surrogate Endpoints

, 2005
openaire   +1 more source

True endpoint reduction by surrogate endpoints

Communications in Statistics - Simulation and Computation, 2016
ABSTRACTThe use of surrogate endpoint, which is becoming widely popular now a days, was introduced in medical research to reduce the time of experiment required for the approval of a drug. Through cost cutting and time saving, the surrogate endpoints can bring profit to the medicine producers. We obtain the expression for the reduction of true samples,
Buddhananda Banerjee, Atanu Biswas
openaire   +2 more sources

Change in albuminuria as a surrogate endpoint [PDF]

Current Opinion in Nephrology and Hypertension, 2019
Chronic kidney disease is a global health problem with few effective therapies available that slow the progression to end-stage renal disease. The established clinical endpoints for renal trials; doubling of serum creatinine or end-stage renal disease, are late manifestations of CKD.
Simke W, Waijer, Ron T, Gansevoort, Hiddo J L, Heerspink   +2 more
openaire   +3 more sources

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Challenge of Surrogate Endpoints

Southern Medical Journal, 2012
Surrogate endpoints are biomarkers that are intended to substitute for clinical endpoints. They have been used to find novel therapeutic targets, improve the statistical power and shorten the duration of clinical trials, and control the cost of conducting research studies.
James L, Furgerson, William N, Hannah, Jennifer C, Thompson   +2 more
openaire   +2 more sources

The Evaluation of Multiple Surrogate Endpoints

Biometrics, 2001
Summary.Surrogate endpoints are desirable because they typically result in smaller, faster efficacy studies compared with the ones using the clinical endpoints. Research on surrogate endpoints has received substantial attention lately, but most investigations have focused on the validity of using a single biomarker as a surrogate.
Xu, Jane, Zeger, Scott L.
openaire   +2 more sources

A surrogate endpoint

2023
In Chapter 3, I utilize publicly available datasets of gene expression and DNA methylation in sarcomas to interrogate PRC2-dependent mechanisms of epigenetic crosstalk. I have shown that loss of PRC2 correlates with a global hypermethylation profile, tumor microenvironment changes, and patient outcome.
openaire   +1 more source

Evaluating surrogate endpoints

Controlled Clinical Trials, 2002
The validation of surrogate endpoints has been studied by Prentice, who presented a definition as well as a set of criteria that are equivalent if the surrogate and true endpoints are binary. Freedman et al. supplemented these criteria with the so-called proportion explained.
openaire   +2 more sources