Results 21 to 30 of about 510,312 (368)

Potential surrogate endpoint for B-cell hematologic malignancy: A systematic review and meta-analysis [PDF]

Scientific Reports
Confirming the patient benefit of progression-free survival (PFS) in B-cell non-Hodgkin lymphoma (B-NHL) and multiple myeloma (MM) has become increasingly challenging due to the improved outcomes brought by novel therapies. In parallel, the U.S. Food and
Satoshi Hirano, Keisuke Hanada, Hideki Maeda   +2 more
doaj   +2 more sources

Bivariate network meta-analysis for surrogate endpoint evaluation. [PDF]

Stat Med, 2019
Surrogate endpoints are very important in regulatory decision making in healthcare, in particular if they can be measured early compared to the long‐term final clinical outcome and act as good predictors of clinical benefit.
Bujkiewicz S, Jackson D, Thompson JR, Turner RM, Städler N, Abrams KR, White IR.   +6 more
europepmc   +3 more sources

Imputation of a true endpoint from a surrogate: application to a cluster randomized controlled trial with partial information on the true endpoint [PDF]

BMC Medical Research Methodology, 2003
Background The Anglia Menorrhagia Education Study (AMES) is a randomized controlled trial testing the effectiveness of an education package applied to general practices.
Duffy Stephen W, Nixon Richard M, Fender Guy RK   +2 more
doaj   +4 more sources

Early Fungicidal Activity as a Candidate Surrogate Endpoint for All-Cause Mortality in Cryptococcal Meningitis: A Systematic Review of the Evidence.

PLoS ONE, 2016
BackgroundCryptococcal meningitis (CM) is a leading cause of HIV-associated mortality. In clinical trials evaluating treatments for CM, biomarkers of early fungicidal activity (EFA) in cerebrospinal fluid (CSF) have been proposed as candidate surrogate ...
Jairo M Montezuma-Rusca, John H Powers, Dean Follmann, Jing Wang, Brigit Sullivan, Peter R Williamson   +5 more
doaj   +2 more sources

Evaluation of six months sputum culture conversion as a surrogate endpoint in a multidrug resistant-tuberculosis trial

PLoS ONE, 2018
The emergence of multidrug resistant-tuberculosis (MDR-TB), defined as Mycobacterium tuberculosis strains with in vitro resistance to at least isoniazid and rifampicin, has necessitated evaluation and validation of appropriate surrogate endpoints for ...
P. Meyvisch, C. Kambili, K. Andries, N. Lounis, Myriam Theeuwes, B. Dannemann, A. Vandebosch, W. Van der Elst, G. Molenberghs, Ariel Alonso   +9 more
semanticscholar   +3 more sources

Surrogate Endpoint [PDF]

Definitions, 2020
openaire   +2 more sources

TTP as a surrogate endpoint in advanced hepatocellular carcinoma treated with molecular targeted therapy: meta-analysis of randomised controlled trials [PDF]

British Journal of Cancer, 2016
Background:Time to progression (TTP) is suggested as a reliable endpoint compared with the progression-free survival in the clinical trials of hepatocellular carcinoma (HCC).
Dae-Won Lee, M. Jang, Kyung-Hun Lee, E. Cho, Jeong‐Hoon Lee, S. Yu, Y. Kim, Jung‐Hwan Yoon, Tae-Yong Kim, Sae-Won Han, D. Oh, S. Im, Tae‐You Kim   +12 more
semanticscholar   +2 more sources

Postoperative prolonged mechanical ventilation in patients with surgically treated pyogenic spondylodiscitis: a surrogate endpoint for early postoperative mortality. [PDF]

Neurosurg Rev, 2023
Scorzin JE, Potthoff AL, Lehmann F, Banat M, Borger V, Schuss P, Bode C, Vatter H, Schneider M.   +8 more
europepmc   +3 more sources

Incorporating Covariates into Measures of Surrogate Paradox Risk

Stats, 2023
Clinical trials often collect intermediate or surrogate endpoints other than their true endpoint of interest. It is important that the treatment effect on the surrogate endpoint accurately predicts the treatment effect on the true endpoint.
Fatema Shafie Khorassani, Jeremy M. G. Taylor, Niko Kaciroti, Michael R. Elliott   +3 more
doaj   +1 more source

Change in albuminuria as a surrogate endpoint for cardiovascular and renal outcomes in patients with diabetes

Diabetes, obesity and metabolism, 2023
For the purpose of predicting clinical outcomes in patients with diabetes and chronic kidney disease, change in albuminuria is a good candidate to be a surrogate marker for future cardiovascular events and progression of kidney disease.
B. Palmer
semanticscholar   +1 more source