Results 21 to 30 of about 82,696 (289)

Effect of estimating equations for glomerular filtration rate on novel surrogate markers for renal outcome [PDF]

Kidney Research and Clinical Practice, 2021
Backgrounds Recently, alternative surrogate endpoints such as a 30% or 40% decline in estimated glomerular filtration rate (eGFR) or eGFR slope over 2 to 3 years have been proposed for predicting renal outcomes.
Kipyo Kim, Eunji Baek, Suryeong Go, Hyung-Eun Son, Ji-Young Ryu, Yongjin Yi, Jong Cheol Jeong, Sejoong Kim, Ho Jun Chin   +8 more
doaj   +1 more source

A perfect correlate does not a surrogate make

BMC Medical Research Methodology, 2003
Background There is common belief among some medical researchers that if a potential surrogate endpoint is highly correlated with a true endpoint, then a positive (or negative) difference in potential surrogate endpoints between randomization groups ...
Kramer Barnett S, Baker Stuart G
doaj   +1 more source

Two Decades of Cardiovascular Trials With Primary Surrogate Endpoints: 1990–2011

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
Background Surrogate endpoint trials test strategies more efficiently but are accompanied by uncertainty about the relationship between changes in surrogate markers and clinical outcomes.
Behnood Bikdeli, Natdanai Punnanithinont, Yasir Akram, Ike Lee, Nihar R. Desai, Joseph S. Ross, Harlan M. Krumholz   +6 more
doaj   +1 more source

Searching for potential surrogate endpoints of overall survival in clinical trials for patients with prostate cancer

Cancer Reports, 2021
Background The purpose of this study was to investigate the correlation between overall survival (OS) and other clinical outcomes in patients with prostate cancer. Further, we conducted subgroup analysis in the correlation of OS.
Hideki Maeda, Kentaro Takeda, Hisashi Urushihara, Tatsuo Kurokawa   +3 more
doaj   +1 more source

Scoping and targeted reviews to support development of SPIRIT and CONSORT extensions for randomised controlled trials with surrogate primary endpoints: protocol

BMJ Open, 2022
Introduction Using a surrogate endpoint as a substitute for a primary patient-relevant outcome enables randomised controlled trials (RCTs) to be conducted more efficiently, that is, with shorter time, smaller sample size and lower cost. However, there is
Derek Stewart, Rod Taylor, Christopher Weir, Oriana Ciani, Philippa Davies, Anthony Muchai Manyara, Valerie Wells   +6 more
doaj   +1 more source

A framework for the definition and interpretation of the use of surrogate endpoints in interventional trialsResearch in context

EClinicalMedicine, 2023
Summary: Background: Interventional trials that evaluate treatment effects using surrogate endpoints have become increasingly common. This paper describes four linked empirical studies and the development of a framework for defining, interpreting and ...
Oriana Ciani, Anthony M. Manyara, Philippa Davies, Derek Stewart, Christopher J. Weir, Amber E. Young, Jane Blazeby, Nancy J. Butcher, Sylwia Bujkiewicz, An-Wen Chan, Dalia Dawoud, Martin Offringa, Mario Ouwens, Asbjørn Hróbjartssson, Alain Amstutz, Luca Bertolaccini, Vito Domenico Bruno, Declan Devane, Christina D.C.M. Faria, Peter B. Gilbert, Ray Harris, Marissa Lassere, Lucio Marinelli, Sarah Markham, John H. Powers, Yousef Rezaei, Laura Richert, Falk Schwendicke, Larisa G. Tereshchenko, Achilles Thoma, Alparslan Turan, Andrew Worrall, Robin Christensen, Gary S. Collins, Joseph S. Ross, Rod S. Taylor   +35 more
doaj   +1 more source

Options for basing Dietary Reference Intakes (DRIs) on chronic disease endpoints: report from a joint US-/Canadian-sponsored working group. [PDF]

, 2016
Dietary Reference Intakes (DRIs) are used in Canada and the United States in planning and assessing diets of apparently healthy individuals and population groups.
Ard, Jamy, Atkinson, Stephanie, Bier, Dennis, Carriquiry, Alicia, Garza, Cutberto, Greene-Finestone, Linda, Harlan, William, Hattis, Dale, King, Janet, Krewski, Daniel, MacFarlane, Amanda, OConnor, Deborah, Prentice, Ross, Rodricks, Joseph, Wells, George, Yetley, Elizabeth   +15 more
core   +1 more source

Correlation between clinical trial endpoints of marketed cancer drugs and reimbursement decisions in China

Frontiers in Public Health, 2022
ObjectiveThis study aimed to assess whether different clinical trial endpoints in pivotal trials of cancer drugs were associated with reimbursement decisions in China.Materials and methodsCancer drugs marketed before June 30th, 2021 with publicly ...
Kexin Ling, Huli Qin, Yiman Feng, Hongxi Che, Jinxi Ding, Jinxi Ding, Wei Li, Wei Li   +7 more
doaj   +1 more source

Surrogate Endpoint Evaluation: Principal Stratification Criteria and the Prentice Definition

Journal of Causal Inference, 2015
A common problem of interest within a randomized clinical trial is the evaluation of an inexpensive response endpoint as a valid surrogate endpoint for a clinical endpoint, where a chief purpose of a valid surrogate is to provide a way to make correct ...
Gilbert Peter B., Gabriel Erin E., Huang Ying, Chan Ivan S.F.   +3 more
doaj   +1 more source

Debate: Are surrogate end-point studies worth the effort?

Current Controlled Trials in Cardiovascular Medicine, 2000
Surrogate end-points of cardiovascular disease can provide useful information in cross-sectional, prospective and interventional studies. They provide information on association with risk factors, natural history and factors associated with disease ...
Elkeles Robert S, Valabhji Jonathan
doaj   +1 more source