Reliability Optimization of the Honeycomb Sandwich Structure Based on A Neural Network Surrogate Model. [PDF]
Materials (Basel), 2023 Wei Z, Zhou C, Zhang F, Zhou C.
europepmc +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
A novel adaptive-weight ensemble surrogate model base on distance and mixture error. [PDF]
PLoS One, 2023 Lu J, Fang Y, Han W.
europepmc +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Generative diffusion model surrogates for mechanistic agent-based biological models
Machine Learning: Science and TechnologyMechanistic, multicellular, agent-based models are commonly used to investigate tissue, organ, and organism-scale biology at single-cell resolution. The Cellular-Potts Model (CPM) is a powerful and popular framework for developing and interrogating these
Tien Comlekoglu +5 more
doaj +1 more source
Research on surrogate model of dam numerical simulation with multiple outputs based on adaptive sampling. [PDF]
Sci Rep, 2023 Liang J +5 more
europepmc +1 more source
Surrogate-modeling for Pavement Maintenance Scheduling
Data Science for TransportationAbstract Incorporating traffic dynamics into pavement maintenance scheduling improves decision quality by accounting for user delays, but it introduces significant computational challenges. Existing approaches rely on detailed macroscopic traffic flow models to evaluate the impact of maintenance activities on user.
Abhishek Kumar Prajapati, Ilgin Guler
openaire +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Embodied Energy Optimization of Prestressed Concrete Road Flyovers by a Two-Phase Kriging Surrogate Model. [PDF]
Materials (Basel), 2023 Yepes-Bellver L +3 more
europepmc +1 more source