Results 91 to 100 of about 185,885 (248)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Surrogate-assisted evolutionary algorithms for expensive combinatorial optimization: a survey

Complex & Intelligent Systems
As potent approaches for addressing computationally expensive optimization problems, surrogate-assisted evolutionary algorithms (SAEAs) have garnered increasing attention.
Shulei Liu, Handing Wang, Wei Peng, Wen Yao   +3 more
doaj   +1 more source

Single and Multi-Objective Optimization of a Three-Dimensional Unbalanced Split-and-Recombine Micromixer

Micromachines, 2019
The three-dimensional geometry of a micromixer with an asymmetrical split-and-recombine mechanism was optimized to enhance the fluid-mixing capability at a Reynolds number of 20. Single and multi-objective optimizations were carried out by using particle
Wasim Raza, Sang-Bum Ma, Kwang-Yong Kim
doaj   +1 more source

Towards Neural Speaker Modeling in Multi-Party Conversation: The Task, Dataset, and Models

, 2018
Neural network-based dialog systems are attracting increasing attention in both academia and industry. Recently, researchers have begun to realize the importance of speaker modeling in neural dialog systems, but there lacks established tasks and datasets.
Jin, Zhi, Meng, Zhao, Mou, Lili
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

End-to-End Deep-Learning-Based Surrogate Modeling for Supersonic Airfoil Shape Optimization

Aerospace
Aerodynamic shape design optimization faces challenges due to the computational demands and the vast design space, limiting its practicality and scalability.
Diogo Pereira, Frederico Afonso, Fernando Lau   +2 more
doaj   +1 more source

Replacing FEA for sheet metal forming by surrogate modeling

Cogent Engineering, 2014
This paper presents an innovative approach for employing surrogate modeling in computer-aided design of sheet metal work pieces. The surrogate models replace expensive finite element analysis and thus shorten development time in the early design stages ...
Simon Wessing, Günter Rudolph, Sven Turck, Christian Klimmek, Sebastian Christopher Schäfer, Michael Schneider, Ulrich Lehmann   +6 more
doaj   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source