Results 91 to 100 of about 186,324 (294)

Deep convolutional encoder-decoder networks for uncertainty quantification of dynamic multiphase flow in heterogeneous media

, 2018
Surrogate strategies are used widely for uncertainty quantification of groundwater models in order to improve computational efficiency. However, their application to dynamic multiphase flow problems is hindered by the curse of dimensionality, the ...
Mo, Shaoxing, Shi, Xiaoqing, Wu, Jichun, Zabaras, Nicholas, Zhu, Yinhao   +4 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Advanced Optimization of Flowshop Scheduling with Maintenance, Learning and Deteriorating Effects Leveraging Surrogate Modeling Approaches

Mathematics
Metaheuristics are powerful optimization techniques that are well-suited for addressing complex combinatorial problems across diverse scientific and industrial domains.
Nesrine Touafek, Fatima Benbouzid-Si Tayeb, Asma Ladj, Riyadh Baghdadi   +3 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Cardiovascular Modeling With Adapted Parametric Inference

ESAIM: Proceedings and Surveys, 2018
Computational modeling of the cardiovascular system, promoted by the advance of fluid-structure interaction numerical methods, has made great progress towards the development of patient-specific numerical aids to diagnosis, risk prediction, intervention ...
Lucor Didier, Le Maître Olivier P.
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Machine learning surrogate for 3D phase-field modeling of ferroelectric tip-induced electrical switching

npj Computational Materials
Phase-field modeling offers a powerful tool for investigating the electrical control of the domain structure in ferroelectrics. However, its broad application is constrained by demanding computational requirements, limiting its utility in inverse design ...
Kévin Alhada–Lahbabi, Damien Deleruyelle, Brice Gautier   +2 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Creating a Real‐Time Capable Surrogate Model of a Wind Turbine Using Machine Learning

Wind Energy
Multibody simulation (MBS) is an established method for modeling wind turbines for purposes such as load calculation. While capable of modeling wind turbines at high levels of detail, large MBS models can be computationally expensive.
Stefan Witter, Jakob Roth, Ralf Schelenz, Georg Jacobs   +3 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source