Results 111 to 120 of about 185,885 (248)

Outlier-Robust Surrogate Modeling of Ion-Solid Interaction Simulations. [PDF]

Entropy (Basel), 2023
Preuss R, von Toussaint U.
europepmc   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

IMPROVED PARTICLE SWARM OPTIMIZATION METHOD DIRECTED BY INDIRECT SURROGATE MODELING

Havacılık ve Uzay Teknolojileri Dergisi, 2015
An improved particle swarm optimization algorithm is proposed and tested for two different test cases: surface fitting of a wing shape and an inverse design of an airfoil in subsonic flow.
Yasin Volkan Pehlivanoğlu, Serdar Ay, Faruk Gül   +2 more
doaj  

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Using machine learning surrogate modeling for faster QSP VP cohort generation. [PDF]

CPT Pharmacometrics Syst Pharmacol, 2023
Myers RC, Augustin F, Huard J, Friedrich CM.   +3 more
europepmc   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

A novel approach to inverse design of wind turbine airfoils using tandem neural networks

Wind Energy
The performance of a wind turbine and its efficiency majorly depends on wind‐to‐rotor efficiency. The aerodynamic design of the wind turbine blades using high‐fidelity tools such as adjoint‐computational fluid dynamics (CFD) is accurate but ...
Apurva Anand, Koushik Marepally, M Muneeb Safdar, James D. Baeder   +3 more
doaj   +1 more source

Cancer drug response prediction with surrogate modeling-based graph neural architecture search. [PDF]

Bioinformatics, 2023
Oloulade BM, Gao J, Chen J, Al-Sabri R, Wu Z.   +4 more
europepmc   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Simulation of Full Wavefield Data with Deep Learning Approach for Delamination Identification

Applied Sciences
In this work, a novel approach of guided wave-based damage identification in composite laminates is proposed. The novelty of this research lies in the implementation of ConvLSTM-based autoencoders for the generation of full wavefield data of propagating ...
Saeed Ullah, Pawel Kudela, Abdalraheem A. Ijjeh, Eleni Chatzi, Wieslaw Ostachowicz   +4 more
doaj   +1 more source