Results 121 to 130 of about 186,324 (294)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

End-to-End Deep-Learning-Based Surrogate Modeling for Supersonic Airfoil Shape Optimization

Aerospace
Aerodynamic shape design optimization faces challenges due to the computational demands and the vast design space, limiting its practicality and scalability.
Diogo Pereira, Frederico Afonso, Fernando Lau   +2 more
doaj   +1 more source

A surrogate FRAX model for Mongolia

Archives of Osteoporosis
Abstract Summary A surrogate FRAX® model for Mongolia has been constructed using age- and sex-specific hip fracture rates for mainland China and age- and sex-specific mortality rates from Mongolia. Introduction FRAX models are frequently requested for countries with little
Jaalkhorol, M., Johansson, H., Avirmed, S., Dashtseren, A., Bruyère, O., Lorentzon, M., Harvey, N.C., McCloskey, E.V., Kanis, J.A.   +8 more
openaire   +4 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

IMPROVED PARTICLE SWARM OPTIMIZATION METHOD DIRECTED BY INDIRECT SURROGATE MODELING

Havacılık ve Uzay Teknolojileri Dergisi, 2015
An improved particle swarm optimization algorithm is proposed and tested for two different test cases: surface fitting of a wing shape and an inverse design of an airfoil in subsonic flow.
Yasin Volkan Pehlivanoğlu, Serdar Ay, Faruk Gül   +2 more
doaj  

Accelerating Urban Drainage Simulations: A Data-Efficient GNN Metamodel for SWMM Flowrates

Engineering Proceedings
Computational models for water resources often experience slow execution times, limiting their application. Metamodels, especially those based on machine learning, offer a promising alternative.
Alexander Garzón, Zoran Kapelan, Jeroen Langeveld, Riccardo Taormina   +3 more
doaj   +1 more source

Outlier-Robust Surrogate Modeling of Ion-Solid Interaction Simulations. [PDF]

Entropy (Basel), 2023
Preuss R, von Toussaint U.
europepmc   +1 more source

Multi-fidelity reduced-order surrogate modelling

Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences
High-fidelity numerical simulations of partial differential equations (PDEs) given a restricted computational budget can significantly limit the number of parameter configurations considered and/or time window evaluated. Multi-fidelity surrogate modelling aims to leverage less accurate, lower-fidelity models that are computationally ...
Paolo Conti, Mengwu Guo, Andrea Manzoni, Attilio Frangi, Steven L. Brunton, J. Nathan Kutz   +5 more
openaire   +5 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Research on Parameter Prediction Model of S-Shaped Inlet Based on FCM-NDAPSO-RBF Neural Network

Aerospace
To address the inefficiencies of traditional numerical simulations and the high cost of experimental validation in the aerodynamic–stealth integrated design of S-shaped inlets for aero-engines, this study proposes a novel parameter prediction model based
Ye Wei, Lingfei Xiao, Xiaole Zhang, Junyuan Hu, Jie Li   +4 more
doaj   +1 more source