Results 171 to 180 of about 186,324 (294)

Surfing on Fitness Landscapes: A Boost on Optimization by Fourier Surrogate Modeling. [PDF]

Entropy (Basel), 2020
Manzoni L, Papetti DM, Cazzaniga P, Spolaor S, Mauri G, Besozzi D, Nobile MS.   +6 more
europepmc   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Surrogate modeling of Cellular-Potts agent-based models as a segmentation task using the U-Net neural network architecture. [PDF]

PLoS Comput Biol
Comlekoglu T, Toledo-Marín JQ, Comlekoglu T, DeSimone DW, Peirce SM, Fox G, Glazier JA.   +6 more
europepmc   +1 more source

ASAMS: An Adaptive Sequential Sampling and Automatic Model Selection for Artificial Intelligence Surrogate Modeling. [PDF]

Sensors (Basel), 2020
Duchanoy CA, Calvo H, Moreno-Armendáriz MA.   +2 more
europepmc   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Nominal elastic modulus assessment in 3D-printed components under varying printing parameters using Bayesian methods and random forest surrogate modeling. [PDF]

PLoS One
Zhang J, Lu L, Feng P, Zhu T.
europepmc   +1 more source

Fast Surrogate Modeling using Dimensionality Reduction in Model Inputs and Field Output: Application to Additive Manufacturing. [PDF]

Reliab Eng Syst Saf, 2020
Vohra M, Nath P, Mahadevan S, Lee YT.
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Sensor-Driven Surrogate Modeling and Control of Nonlinear Dynamical Systems Using FAE-CAE-LSTM and Deep Reinforcement Learning. [PDF]

Sensors (Basel)
Kherad M, Moayyedi MK, Fotouhi-Ghazvini F, Vahabi M, Fotouhi H.   +4 more
europepmc   +1 more source

Avoiding overfitting in surrogate modeling: an alternative approach [PDF]

, 2011
Couckuyt, Ivo, Dhaene, Tom, Gorissen, Dirk, Knockaert, Luc, Nguyen, Huu Minh, Saeys, Yvan   +5 more
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