Results 81 to 90 of about 185,885 (248)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Machine learning surrogate for 3D phase-field modeling of ferroelectric tip-induced electrical switching

npj Computational Materials
Phase-field modeling offers a powerful tool for investigating the electrical control of the domain structure in ferroelectrics. However, its broad application is constrained by demanding computational requirements, limiting its utility in inverse design ...
Kévin Alhada–Lahbabi, Damien Deleruyelle, Brice Gautier   +2 more
doaj   +1 more source

Multi-Objective Optimizations of a Serpentine Micromixer with Crossing Channels at Low and High Reynolds Numbers

Micromachines, 2018
In order to maximize the mixing performance of a micromixer with an integrated three-dimensional serpentine and split-and-recombination configuration, multi-objective optimizations were performed at two different Reynolds numbers, 1 and 120, based on ...
Wasim Raza, Sang-Bum Ma, Kwang-Yong Kim
doaj   +1 more source

A Gaussian Mixture MRF for Model-Based Iterative Reconstruction with Applications to Low-Dose X-ray CT

, 2016
Markov random fields (MRFs) have been widely used as prior models in various inverse problems such as tomographic reconstruction. While MRFs provide a simple and often effective way to model the spatial dependencies in images, they suffer from the fact ...
Bouman, Charles A., Pal, Debashish, Sauer, Ken D., Thibault, Jean-Baptiste, Ye, Dong Hye, Zhang, Ruoqiao   +5 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Creating a Real‐Time Capable Surrogate Model of a Wind Turbine Using Machine Learning

Wind Energy
Multibody simulation (MBS) is an established method for modeling wind turbines for purposes such as load calculation. While capable of modeling wind turbines at high levels of detail, large MBS models can be computationally expensive.
Stefan Witter, Jakob Roth, Ralf Schelenz, Georg Jacobs   +3 more
doaj   +1 more source

Replication or exploration? Sequential design for stochastic simulation experiments

, 2019
We investigate the merits of replication, and provide methods for optimal design (including replicates), with the goal of obtaining globally accurate emulation of noisy computer simulation experiments.
Binois, Mickael, Gramacy, Robert B, Huang, Jiangeng, Ludkovski, Mike   +3 more
core   +2 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Accurate and uncertainty-aware multi-task prediction of HEA properties using prior-guided deep Gaussian processes

npj Computational Materials
Surrogate modeling techniques have become indispensable in accelerating the discovery and optimization of high-entropy alloys (HEAs), especially when integrating computational predictions with sparse experimental observations.
Sk Md Ahnaf Akif Alvi, Mrinalini Mulukutla, Nicolás Flores, Danial Khatamsaz, Jan Janssen, Danny Perez, Douglas Allaire, Vahid Attari, Raymundo Arróyave   +8 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source