Results 121 to 130 of about 456,731 (293)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

open access: yesMolecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta   +10 more
wiley   +1 more source

Neural architecture search using network embedding and generative adversarial networks

open access: yesScientific Reports
Surrogate models are used by recently proposed algorithms as a means of forecasting neural architecture performance. Rather than training the network from scratch, which speeds up evaluation of performance in the search for neural architecture.
Morteza Yousefi   +2 more
doaj   +1 more source

A surrogate FRAX model for Mongolia

open access: yesArchives of Osteoporosis
Abstract Summary A surrogate FRAX® model for Mongolia has been constructed using age- and sex-specific hip fracture rates for mainland China and age- and sex-specific mortality rates from Mongolia. Introduction FRAX models are frequently requested for countries with little
Jaalkhorol, M.   +8 more
openaire   +4 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Research on Surrogate Model of Dam Structural Behavior for Multi‐Output Problem

open access: yesEngineering Reports
The establishment efficiency of the surrogate model is often affected by the multi‐output problem during the establishment process. It is an urgent issue to solve how to establish a multi‐output joint surrogate model more quickly while ensuring a certain
Yuan Qiao   +3 more
doaj   +1 more source

Physics-Based AI-Driven Surrogate Modeling for Structural Displacement Prediction in Mechanical Systems With Limited Sensor Data

open access: yesIEEE Access
This study introduces a machine learning (ML)-based surrogate model for finite element analysis, designed to predict structural strain distributions using a minimal number of strategically placed virtual sensors.
Ali Hashemi   +2 more
doaj   +1 more source

Continuous-Time Surrogate Models for Data-Driven Dynamic Optimization. [PDF]

open access: yesESCAPE, 2022
Beykal B   +2 more
europepmc   +1 more source

Multi-fidelity reduced-order surrogate modelling

open access: yesProceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences
High-fidelity numerical simulations of partial differential equations (PDEs) given a restricted computational budget can significantly limit the number of parameter configurations considered and/or time window evaluated. Multi-fidelity surrogate modelling aims to leverage less accurate, lower-fidelity models that are computationally ...
Paolo Conti   +5 more
openaire   +5 more sources

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