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A PDCD4-Based Gene Expression Signature Predicts Overall Survival in Renal Cell Carcinoma: A TCGA-Based Discovery and External Validation Study [PDF]
Current Issues in Molecular BiologyRenal cell carcinoma (RCC) is a heterogeneous disease with variable clinical outcomes. PDCD4 functions as a tumor suppressor, but its role in RCC prognosis remains unclear.
Bandar A. Suliman
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Brain tumour genetic network signatures of survival
Brain, 2023 Abstract Tumour heterogeneity is increasingly recognized as a major obstacle to therapeutic success across neuro-oncology. Gliomas are characterized by distinct combinations of genetic and epigenetic alterations, resulting in complex interactions across multiple molecular pathways.
James K Ruffle +8 more
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New Autophagy-Ferroptosis Gene Signature Predicts Survival in Glioma [PDF]
Frontiers in Cell and Developmental Biology, 2021 Background: Ferroptosis plays an important role in glioma and significantly affects the prognosis, but the specific mechanism has not yet been elucidated. Recent studies suggest that autophagy regulates the process of ferroptosis. This study aimed to find potential autophagy-ferroptosis genes and explore the prognostic significance in glioma.Methods ...
Liwei Zhou +21 more
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Frontiers in Genetics, 2021 BackgroundSome studies have proven that autophagy and lncRNA play important roles in AML. Several autophagy related lncRNA signatures have been shown to affect the survival of patients in some other cancers.
Chunxia Zhao +7 more
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Frontiers in Cell and Developmental Biology, 2021 In this study, we identified eight survival-related metabolic genes in differentially expressed metabolic genes by univariate Cox regression analysis based on the therapeutically applicable research to generate effective treatments (n = 84) data set and ...
Gong Chao-yang +9 more
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ABI1‐based expression signature predicts breast cancer metastasis and survival
Molecular Oncology, 2022 Despite the current standard of care, breast cancer remains one of the leading causes of mortality in women worldwide, thus emphasizing the need for better predictive and therapeutic targets. ABI1 is associated with poor survival and an aggressive breast
Angelina Regua +10 more
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A pseudogene-signature in glioma predicts survival [PDF]
Journal of Experimental & Clinical Cancer Research, 2015 Pseudogene was recognized as a potential tumor suppressor or oncogene in varies of diseases, however its roles in glioma have not been investigated. Our study was to identify the pseudogene-signature that predicted glioma survival. Using a pseudogene-mining approach, we performed pseudogene expression profiling in 183 glioma samples from the Chinese ...
Gao, Kai-Ming +5 more
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Mutational Signatures Associate With Survival in Gastrointestinal Carcinomas
Cancer Genomics - Proteomics, 2022 Mutational signatures reflect common patterns based on the counts of mutations and their sequence context. The prognostic value of these signatures, mirroring various carcinogenetic processes of cancers, are unexplored in gastrointestinal cancers.
Karihtala, P. (Peeter) +2 more
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Melanoma MicroRNA Signature Predicts Post-Recurrence Survival [PDF]
Clinical Cancer Research, 2010 Abstract Purpose: To identify a melanoma microRNA (miRNA) expression signature that is predictive of outcome and then evaluate its potential to improve risk stratification when added to the standard-of-care staging criteria. Experimental Design: Total RNA was extracted from 59 formalin-fixed paraffin-embedded ...
Miguel F, Segura +11 more
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Computational and Structural Biotechnology Journal, 2022 Identifying a miRNA signature associated with survival will open a new window for developing miRNA-targeted treatment strategies in stomach and esophageal cancers (STEC).
Srinivasulu Yerukala Sathipati +6 more
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