Survivin 2α: a novel Survivin splice variant expressed in human malignancies [PDF]
Molecular Cancer, 2005 Background Survivin and its alternative splice forms are involved in critical cellular processes, including cell division and programmed cell death. Survivin is expressed in the majority of human cancers, but minimally in differentiated normal tissues ...
Honsey Laura E +2 more
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Prognostic value and targeted inhibition of survivin expression in esophageal adenocarcinoma and cancer-adjacent squamous epithelium. [PDF]
PLoS ONE, 2013 Survivin is an inhibitor of apoptosis and its over expression is associated with poor prognosis in several malignancies. While several studies have analyzed survivin expression in esophageal squamous cell carcinoma, few have focused on esophageal ...
Usha Malhotra +13 more
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Phosphorylation Modulates Survivin Function in Behcet’s Disease [PDF]
Advanced Pharmaceutical Bulletin, 2020 Purpose: Survivin is critical for proliferation, maturation, homeostasis and differentiation of effector and memory lymphocytes. In this study the baculoviral inhibitors of apoptosis proteins (IAPs) repeat containing 5 (BIRC5) mRNA, survivin, and ...
Yasamin Pahlavan +3 more
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SURVIVIN EXPRESSION IN ORAL SQUAMOUS CELL CARCINOMA [PDF]
Sanamed, 2023 Introduction: Survivin functions as an apoptosis inhibitor and a regulator of cell division. This study aimed to determine the correlation between survivin expression and clinicopathologic parameters of oral squamous cell carcinoma (OSCC) and determine ...
Antunovic Marija, Raonic Janja
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Survivin prevents the polycomb repressor complex 2 from methylating histone 3 lysine 27
iScience, 2023 Summary: This study investigates the role of survivin in epigenetic control of gene transcription through interaction with the polycomb repressive complex 2 (PRC2).
Maja Jensen +12 more
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Clinicopathologic Significance of Survivin Expression in Relation to CD133 Expression in Surgically Resected Stage II or III Colorectal Cancer [PDF]
Journal of Pathology and Translational Medicine, 2017 Background Cancer stem cells have been investigated as new targets for colorectal cancer (CRC) treatment. We recently reported that CD133+ colon cancer cells showed chemoresistance to 5-fluorouracil through increased survivin expression and proposed the ...
Wanlu Li +3 more
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Phosphorylated-Survivin at Ser81 Induced Protein Kinase A (PKA): A Back Loop
Indonesian Biomedical Journal, 2011 BACKGROUND: Survivin, a bifunctional protein, acts as suppressor of apoptosis and has an essential role in mitosis. Survivin is physically phosphorylated on Thr34, and other important sites such as Thr117, Ser20, Thr48 and Ser81.
Ferry Sandra, Roya Khosravi-Far
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Phosphorylation of survivin at threonine 34 inhibits its mitotic function and enhances its cytoprotective activity [PDF]
, 2009 Survivin is an essential chromosomal passenger protein required for mitotic progression. It is also an inhibitor of apoptosis and can prevent caspase-mediated cell death.
Barrett, Rachel M.A. +2 more
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Expression of survivin and its splice variants survivin-2B and survivin-ΔEx3 in breast cancer [PDF]
British Journal of Cancer, 2004 Alternative splicing of survivin mRNA gives rise to multiple isoforms, that is, survivin and 3 splice variants, survivin-2B, survivin-3B and survivin-DeltaEx3. The aim of this study was to compare the expression of survivin, survivin-2B and survivin-DeltaEx3 in normal breast tissue, fibroadenomas, primary breast cancer and axillary nodal metastases ...
Ryan, B +8 more
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Journal of Experimental & Clinical Cancer Research, 2019 Survivin (also named BIRC5) is a well-known cancer therapeutic target. Since its discovery more than two decades ago, the use of survivin as a target for cancer therapeutics has remained a central goal of survivin studies in the cancer field.
Fengzhi Li, Ieman Aljahdali, Xiang Ling
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