Survivin 2α: a novel Survivin splice variant expressed in human malignancies [PDF]
Molecular Cancer, 2005 Background Survivin and its alternative splice forms are involved in critical cellular processes, including cell division and programmed cell death. Survivin is expressed in the majority of human cancers, but minimally in differentiated normal tissues ...
Honsey Laura E +2 more
doaj +3 more sources
Expression of survivin and its splice variants survivin-2B and survivin-ΔEx3 in breast cancer [PDF]
British Journal of Cancer, 2004 Alternative splicing of survivin mRNA gives rise to multiple isoforms, that is, survivin and 3 splice variants, survivin-2B, survivin-3B and survivin-DeltaEx3. The aim of this study was to compare the expression of survivin, survivin-2B and survivin-DeltaEx3 in normal breast tissue, fibroadenomas, primary breast cancer and axillary nodal metastases ...
Ryan, B +8 more
openaire +2 more sources
Survivin as a therapeutic target in Sonic hedgehog-driven medulloblastoma. [PDF]
, 2015 Medulloblastoma (MB) is a highly malignant brain tumor that occurs primarily in children. Although surgery, radiation and high-dose chemotherapy have led to increased survival, many MB patients still die from their disease, and patients who survive ...
Berezov, A +17 more
core +2 more sources
Clinicopathological and prognostic significance of survivin over-expression in patients with esophageal squamous cell carcinoma: a meta-analysis. [PDF]
PLoS ONE, 2012 BACKGROUND:The prognostic significance of survivin for survival of patients with esophageal squamous cell carcinoma (ESCC) remains controversial. Thus, meta-analysis of the literatures was performed in order to demonstrate its expression impact on ESCC ...
Chunguang Li +7 more
doaj +1 more source
Indonesian Biomedical Journal, 2014 BACKGROUND: Our previous report showed that phosphorylated-survivin at Ser81 induces survivin back loop to activate protein kinase A (PKA) in the cytoprotection mechanism.
Ferry Sandra, Roya Khosravi-Far
doaj +1 more source
The kinesin Eg5 inhibitor K858 induces apoptosis but also survivin-related chemoresistance in breast cancer cells [PDF]
, 2016 Inhibitors of kinesin spindle protein Eg5 are characterized by pronounced antitumor activity. Our group has recently synthesized and screened a library of 1,3,4-thiadiazoline analogues with the pharmacophoric structure of K858, an Eg5 inhibitor.
CARRADORI, Simone +8 more
core +1 more source
Survivin S81A Enhanced TRAIL's Activity in Inducing Apoptosis
Indonesian Biomedical Journal, 2010 BACKGROUND: Survivin is rarely expressed in normal healthy adult tissues, however, it is upregulated in the majority of cancers. Survivin, which belongs to IAPs family, has been widely reported to protect cells from apoptosis by inhibiting caspases ...
Ferry Sandra, Roya Khosravi-Far
doaj +1 more source
Survivin a radiogenetic promoter for glioblastoma viral gene therapy independently from CArG motifs [PDF]
, 2017 BACKGROUND: Radiogenetic therapy is a novel approach in the treatment of cancer, which employs genetic modification to alter the sensitivity of tumor cells to the effect of applied radiation.
Arafat WO +16 more
core +2 more sources
Scientific Reports, 2022 Overexpression of survivin is frequently observed in human malignancies and is associated with poor prognosis. The present study found that survivin is highly expressed in nasopharyngeal carcinoma (NPC) tumor tissues.
Xin Dong +6 more
doaj +1 more source
A new survivin tracer tracks, delocalizes and captures endogenous survivin at different subcellular locations and in distinct organelles [PDF]
, 2016 Survivin, the smallest member of the inhibitor of apoptosis protein family, plays a central role during mitosis and exerts a cytoprotective function. Survivin is highly expressed in most cancer types and contributes to multiple facets of carcinogenesis ...
Beghein, Els +5 more
core +2 more sources