Results 31 to 40 of about 59,431 (239)

BcCluster: a bladder cancer database at the molecular level [PDF]

, 2016
Background: Bladder Cancer (BC) has two clearly distinct phenotypes. Non-muscle invasive BC has good prognosis and is treated with tumor resection and intravesical therapy whereas muscle invasive BC has poor prognosis and requires usually systemic ...
Bhat, Akshay, Jankowski, Vera, Mischak, Harald, Mokou, Marika, Vlahou, Antonia, Zoidakis, Jerome   +5 more
core   +3 more sources

Effect of Terminal Groups of Dendrimers in the Complexation with Antisense Oligonucleotides and Cell Uptake [PDF]

, 2016
Indexación: Web of Science.Poly(amidoamine) dendrimers are the most recognized class of dendrimer. Amino-terminated (PAMAM-NH2) and hydroxyl-terminated (PAMAM-OH) dendrimers of generation 4 are widely used, since they are commercially available.
Araya-Durán, Ingrid, Céric, Francisco, Fuentes, Juan, González-Nilo, Fernando D., Márquez-Miranda, Valeria, Otero, Carolina, Peñaloza, Juan Pablo, Reyes, Rodrigo, Romero, Valentina, Velásquez, Luis, Vidaurre, Soledad   +10 more
core   +1 more source

Subcellular Compartmentalization of Survivin is Associated with Biological Aggressiveness and Prognosis in Prostate Cancer

Scientific Reports, 2020
The role of subcellular survivin compartmentalization in the biology and prognosis of prostate cancer is unclear. We therefore investigated subcellular localization of survivin in more than 3000 prostate cancer patients by quantitative ...
Jan K. Hennigs, Sarah Minner, Pierre Tennstedt, Rolf Löser, Hartwig Huland, Hans Klose, Markus Graefen, Thorsten Schlomm, Guido Sauter, Carsten Bokemeyer, Friedemann Honecker   +10 more
doaj   +1 more source

The inner centromere is a biomolecular condensate scaffolded by the chromosomal passenger complex. [PDF]

, 2019
The inner centromere is a region on every mitotic chromosome that enables specific biochemical reactions that underlie properties, such as the maintenance of cohesion, the regulation of kinetochores and the assembly of specialized chromatin, that can ...
A Chakraborty, A Jain, AE Kelly, AG Larson, AM Ainsztein, AR Strom, B Banerjee, B Bolognesi, BG Fuller, BR Sabari, E Niedzialkowska, E Wang, Enrico Gratton, Ewa Niedzialkowska, F Cardarelli, F Sessa, F Wang, Francesco Palomba, J Chen, J Du, JB Woodruff, JG Ruppert, K Jaqaman, KM Sathyan, KS Bloom, L Scipioni, M Delacour-Larose, M Wachsmuth, M Wühr, Michelle A. Digman, ML Hanley, MS Wheelock, P Trivedi, P Trivedi, P. Todd Stukenberg, PDJ Moens, Prasad Trivedi, R Mahen, RCC Hengeveld, S Ambadipudi, S Hauf, S Hindriksen, SC Sampath, SE Rosasco-Nitcher, SF Banani, Shasha Chong, SM Janicki, SP Wheatley, T Hirota, T Tsukahara, UR Klein, VA Beardmore, W Fischle, X Liu, Y Abe, Y Shin, Y Yamagishi, Y Yamagishi   +57 more
core   +2 more sources

Survivin Ser81 Plays An Important Role in PI3K/Akt/mTOR Signaling Pathway

MCBS (Molecular and Cellular Biomedical Sciences), 2018
Background: Survivin, a member of the inhibitor of apoptosis protein family, has been associated with protection from cell apoptosis and regulation of mitosis. Phosphorylated-Survivin at Ser81 was reported to provide cytoprotection against tumor necrosis
Ferry Sandra
doaj   +1 more source

Does Notch play a tumor suppressor role across diverse squamous cell carcinomas? [PDF]

, 2016
The role of Notch pathway in tumorigenesis is highly variable. It can be tumor suppressive or pro-oncogenic, typically depending on the cellular context.
Biswas, Sangita, Deng, Wenbing, Gong, Wenrong, Qin, Xin, Yu, Hongjun, Zhang, Min   +5 more
core   +1 more source

Loss of survivin in the prostate epithelium impedes carcinogenesis in a mouse model of prostate adenocarcinoma. [PDF]

PLoS ONE, 2013
The inhibitor of apoptosis protein survivin is expressed in most cancers. Using the conditional PTEN deletion mouse model, we previously reported that survivin levels increase with prostate tumor growth.
Helty Adisetiyo, Mengmeng Liang, Chun-Peng Liao, Ari Aycock-Williams, Michael B Cohen, Shili Xu, Nouri Neamati, Edward M Conway, Chieh-Yang Cheng, Alexander Yu Nikitin, Pradip Roy-Burman   +10 more
doaj   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Prognostic Significance of Nuclear Survivin Expression in Resected Adenoid Cystic Carcinoma of the Head and Neck [PDF]

, 2010
Objectives The expression of survivin, an inhibitor of apoptosis, in tumor cells is associated with poor clinical outcome for various cancers. We conducted this study to determine survivin expression in patients with adenoid cystic carcinoma (
Yoon Ko, Sang-Young Roh, Hye Won, Eun Jeon, Sook Hong, Myung Lee, Jin Kang, Young Hong, Min Kim, Chan-Kwon Jung   +9 more
core   +1 more source

Survivin, Survivin-2B, and Survivin-deItaEx3 expression in medulloblastoma: biologic markers of tumour morphology and clinical outcome [PDF]

British Journal of Cancer, 2005
Survivin is an apoptotic inhibitor that is expressed at high levels in a variety of malignancies. Survivin has four known alternative splice forms (Survivin, Survivin-2B, Survivin-deltaEx3, and Survivin-3B), and the recent literature suggests that these splice variants have unique functions and subcellular localisation patterns.
Fangusaro, J R, Jiang, Y, Holloway, M P, Caldas, H, Singh, V, Boué, D R, Hayes, J, Altura, R A   +7 more
openaire   +2 more sources