Results 31 to 40 of about 60,299 (235)

Effect of Terminal Groups of Dendrimers in the Complexation with Antisense Oligonucleotides and Cell Uptake [PDF]

, 2016
Indexación: Web of Science.Poly(amidoamine) dendrimers are the most recognized class of dendrimer. Amino-terminated (PAMAM-NH2) and hydroxyl-terminated (PAMAM-OH) dendrimers of generation 4 are widely used, since they are commercially available.
Araya-Durán, Ingrid, Céric, Francisco, Fuentes, Juan, González-Nilo, Fernando D., Márquez-Miranda, Valeria, Otero, Carolina, Peñaloza, Juan Pablo, Reyes, Rodrigo, Romero, Valentina, Velásquez, Luis, Vidaurre, Soledad   +10 more
core   +1 more source

Survivin Ser81 Plays An Important Role in PI3K/Akt/mTOR Signaling Pathway

MCBS (Molecular and Cellular Biomedical Sciences), 2018
Background: Survivin, a member of the inhibitor of apoptosis protein family, has been associated with protection from cell apoptosis and regulation of mitosis. Phosphorylated-Survivin at Ser81 was reported to provide cytoprotection against tumor necrosis
Ferry Sandra
doaj   +1 more source

Subcellular Compartmentalization of Survivin is Associated with Biological Aggressiveness and Prognosis in Prostate Cancer

Scientific Reports, 2020
The role of subcellular survivin compartmentalization in the biology and prognosis of prostate cancer is unclear. We therefore investigated subcellular localization of survivin in more than 3000 prostate cancer patients by quantitative ...
Jan K. Hennigs, Sarah Minner, Pierre Tennstedt, Rolf Löser, Hartwig Huland, Hans Klose, Markus Graefen, Thorsten Schlomm, Guido Sauter, Carsten Bokemeyer, Friedemann Honecker   +10 more
doaj   +1 more source

Does Notch play a tumor suppressor role across diverse squamous cell carcinomas? [PDF]

, 2016
The role of Notch pathway in tumorigenesis is highly variable. It can be tumor suppressive or pro-oncogenic, typically depending on the cellular context.
Biswas, Sangita, Deng, Wenbing, Gong, Wenrong, Qin, Xin, Yu, Hongjun, Zhang, Min   +5 more
core   +1 more source

Towards More Robust Nanobioscience: Launching the NanoBubbles Replication Initiative

Angewandte Chemie, EarlyView.
The NanoBubbles Reproducibility Initiative investigates the robustness of highly cited articles in nanobioscience. Here, we document the process of setting up the initiative from corpus creation to publishing results. We also present platforms that we adopted and challenges that we faced.
Maha Said, Mustafa Gharib, Raphaël Lévy   +2 more
wiley   +2 more sources

The inner centromere is a biomolecular condensate scaffolded by the chromosomal passenger complex. [PDF]

, 2019
The inner centromere is a region on every mitotic chromosome that enables specific biochemical reactions that underlie properties, such as the maintenance of cohesion, the regulation of kinetochores and the assembly of specialized chromatin, that can ...
A Chakraborty, A Jain, AE Kelly, AG Larson, AM Ainsztein, AR Strom, B Banerjee, B Bolognesi, BG Fuller, BR Sabari, E Niedzialkowska, E Wang, Enrico Gratton, Ewa Niedzialkowska, F Cardarelli, F Sessa, F Wang, Francesco Palomba, J Chen, J Du, JB Woodruff, JG Ruppert, K Jaqaman, KM Sathyan, KS Bloom, L Scipioni, M Delacour-Larose, M Wachsmuth, M Wühr, Michelle A. Digman, ML Hanley, MS Wheelock, P Trivedi, P Trivedi, P. Todd Stukenberg, PDJ Moens, Prasad Trivedi, R Mahen, RCC Hengeveld, S Ambadipudi, S Hauf, S Hindriksen, SC Sampath, SE Rosasco-Nitcher, SF Banani, Shasha Chong, SM Janicki, SP Wheatley, T Hirota, T Tsukahara, UR Klein, VA Beardmore, W Fischle, X Liu, Y Abe, Y Shin, Y Yamagishi, Y Yamagishi   +57 more
core   +2 more sources

Loss of survivin in the prostate epithelium impedes carcinogenesis in a mouse model of prostate adenocarcinoma. [PDF]

PLoS ONE, 2013
The inhibitor of apoptosis protein survivin is expressed in most cancers. Using the conditional PTEN deletion mouse model, we previously reported that survivin levels increase with prostate tumor growth.
Helty Adisetiyo, Mengmeng Liang, Chun-Peng Liao, Ari Aycock-Williams, Michael B Cohen, Shili Xu, Nouri Neamati, Edward M Conway, Chieh-Yang Cheng, Alexander Yu Nikitin, Pradip Roy-Burman   +10 more
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Survivin, Survivin-2B, and Survivin-deItaEx3 expression in medulloblastoma: biologic markers of tumour morphology and clinical outcome [PDF]

British Journal of Cancer, 2005
Survivin is an apoptotic inhibitor that is expressed at high levels in a variety of malignancies. Survivin has four known alternative splice forms (Survivin, Survivin-2B, Survivin-deltaEx3, and Survivin-3B), and the recent literature suggests that these splice variants have unique functions and subcellular localisation patterns.
Fangusaro, J R, Jiang, Y, Holloway, M P, Caldas, H, Singh, V, Boué, D R, Hayes, J, Altura, R A   +7 more
openaire   +2 more sources

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source