Results 51 to 60 of about 60,299 (235)

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Targeting Hsp90 with small molecule inhibitors induces the over-expression of the anti-apoptotic molecule, survivin, in human A549, HONE-1 and HT-29 cancer cells

Molecular Cancer, 2010
Background Survivin is a dual functioning protein. It inhibits the apoptosis of cancer cells by inhibiting caspases, and also promotes cancer cell growth by stabilizing microtubules during mitosis. Since the molecular chaperone Hsp90 binds and stabilizes
Lyu Kevin W, Kanwar Jagat R, Cheng Li-Ting, Chen Huang-Hui, Cheung Chun Hei Antonio, Chang Jang-Yang   +5 more
doaj   +1 more source

In silico and in vitro studies on the anti-cancer activity of andrographolide targeting survivin in human breast cancer stem cells.

PLoS ONE, 2020
Breast cancer stem cells (BCSCs) express high levels of the anti-apoptotic protein, survivin. This study aimed to discover a natural active compound with anti-cancer properties that targeted survivin in human breast cancer stem cells.
Septelia Inawati Wanandi, Agus Limanto, Elvira Yunita, Resda Akhra Syahrani, Melva Louisa, Agung Eru Wibowo, Sekar Arumsari   +6 more
doaj   +1 more source

Synthesis of Curcumin Derivatives and Analysis of Their Antitumor Effects in Triple Negative Breast Cancer (TNBC) Cell Lines [PDF]

, 2019
We analyzed antitumor effects of a series of curcumin analogues. Some of them were obtained by reaction of substitution involving the two phenolic OH groups of curcumin while the analogues with a substituent at C-4 was prepared following an original ...
Barattucci A, Bonaccorsi PM, Labbozzetta M, Notarbartolo M, Poma P, Salerno TMG   +5 more
core   +1 more source

Lactoferrin's anti-cancer properties. Safety, selectivity, and wide range of action [PDF]

, 2020
Despite recent advances in cancer therapy, current treatments, including radiotherapy, chemotherapy, and immunotherapy, although beneficial, present attendant side effects and long-term sequelae, usually more or less affecting quality of life of the ...
Bonaccorsi di Patti, M. C., Cutone, A., Ianiro, G., Lepanto, M. S., Musci, G., Rosa, L., Valenti, P.   +6 more
core   +1 more source

RNA‐Micelles as Self‐Assembling Structures for Efficient Co‐Delivery of Synergistic siRNA and Nucleoside Analogues to Treat CRC Lung Metastasis

Advanced Functional Materials, EarlyView.
Two kinds of self‐assembled RNA micelles were used to co‐deliver synergistic siRNA and nucleoside analogues for the treatment of colorectal cancer lung metastases. Near‐complete elimination of lung cancer metastases was confirmed in an orthotopic lung metastasis model constructed using human colorectal cancer lung metastases patient surgical samples to
Kai Jin, Piotr Rychahou, Daniel W. Binzel, B. Mark Evers, Peixuan Guo   +4 more
wiley   +1 more source

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

Effect of hypoxia-inducible factor-1α on transcription of survivin in non-small cell lung cancer

Journal of Experimental & Clinical Cancer Research, 2009
Background Survivin is a structurally and functionally unique member of the inhibitor of apoptosis protein (IAP) family. It plays an important role, not only in regulating mitosis but also in inhibiting apoptosis.
Li Wei, Zhao Cheng-Ling, Chen Yu-Qing
doaj   +1 more source

Survivin and its prognostic significance in pediatric acute B-cell precursor lymphoblastic leukemia

Haematologica, 2007
Background and Objectives Impaired apoptosis, mediated by members of the inhibitor of apoptosis proteins (IAP) family such as survivin, is thought to contribute to leukemic cell survival. In contrast to low expression of survivin in normal differentiated
Anja Troeger, Meinolf Siepermann, Gabriele Escherich, Roland Meisel, Reinhardt Willers, Sonja Gudowius, Thomas Moritz, Hans-Juergen Laws, Helmut Hanenberg, Ulrich Goebel, Gritta E. Janka-Schaub, Csaba Mahotka, Dagmar Dilloo   +12 more
doaj   +1 more source

Reference Profile Correlation Reveals Estrogen-like Trancriptional Activity of Curcumin [PDF]

, 2010
Background: Several secondary metabolites from herbal nutrient products act as weak estrogens (phytoestrogens), competing with endogenous estrogen for binding to the estrogen receptors and inhibiting steroid converting enzymes.
Albini, Adriana, Bachmeier, Beatrice E., Blengio, Fabiola, Dell'Eva, Raffaella, Esposito, Alessia, Generoso, Luca, Killian, Peter H., Mirisola, Valentina, Pfeffer, Ulrich, Romeo, Francesco   +9 more
core   +1 more source