Results 121 to 130 of about 503,154 (248)

Genetic Control of Left Atrial Gene Expression Yields Insights into the Genetic Susceptibility for Atrial Fibrillation [PDF]

, 2018
Jeffrey Hsu, Shamone R. Gore-Panter, Gregory Tchou, Laurie Castel, Beth Lovano, Christine S. Moravec, Gösta Pettersson, Eric E. Roselli, A. Marc Gillinov, Kenneth R. McCurry, Nicholas G. Smedira, John Barnard, David R. Van Wagoner, Mina K. Chung, Jonathan D. Smith   +14 more
openalex   +1 more source

Versatile Cell Penetrating Peptide for Multimodal CRISPR Gene Editing in Primary Stem Cells

Advanced Functional Materials, EarlyView.
CRISPR machinery in diverse molecular formats (DNA, RNA, and ribonucleic protein) is complexed into nanoparticles with the cell‐friendly arginine‐alanine‐leucine‐alanine (RALA) cell‐penetrating peptide. Nanoparticles are delivered to primary mesenchymal stem cells ex vivo or locally in vivo to facilitate multimodal CRISPR gene editing. This RALA‐CRISPR
Joshua P. Graham, Jose Gabriel Castro, Lisette C. Werba, Joseph Amitrano, Luke Fardone, Kevin P. Francis, Anand Ramamurthi, Michael J. Layden, Helen O. McCarthy, Tomas Gonzalez‐Fernandez   +9 more
wiley   +1 more source

Variants of Novel Immunomodulatory Fc Receptor Like 5 Gene Are Associated With Multiple Sclerosis Susceptibility in the Polish Population [PDF]

, 2021
Monika Chorąży, Natalia Wawrusiewicz‐Kurylonek, Edyta Adamska-Patruno, Agata Czarnowska, Olga Zajkowska, Katarzyna Kapica-Topczewska, Renata Posmyk, Adam Krętowski, Jan Kochanowicz, Alina Kułakowska   +9 more
openalex   +1 more source

Plasma‐Treated Hydrogel for Combined RONS and Chemotherapy Delivery: A Proof‐of‐Concept In Ovo

Advanced Functional Materials, EarlyView.
This study explores plasma‐treated hydrogels (PTH) as a new way to deliver both reactive oxygen and nitrogen species and chemotherapy (Doxorubicin) directly to tumors. In ovo tests show effects after a single dose, especially in osteosarcoma tumors. Tumor weight decrease, and a resistance‐related protein is reduced.
Milica Živanić, Albert Espona‐Noguera, Angela Privat Maldonado, Patrik Matušů, Francesco Tampieri, Maria‐Pau Ginebra, Abraham Lin, Evelien Smits, Annemie Bogaerts, Cristina Canal   +9 more
wiley   +1 more source

Klebsiella infections in a pediatric intensive care unit: incidence, antimicrobial susceptibility, and resistance genes [PDF]

, 2022
Ahmed El‐Nawawy, Marwa Ahmed Meheissen, Ahmed Badr, Manal A.-M. Antonios   +3 more
openalex   +1 more source

Machine Learning‐Enabled Polymer Discovery for Enhanced Pulmonary siRNA Delivery

Advanced Functional Materials, EarlyView.
This study provides an efficient approach to train a machine learning model by merging heterogeneous literature data to predict suitable polymers for siRNA delivery. Without the need for extensive laboratory synthesis, the machine learning enabled a virtual screening and successfully predicted a polymer that is validated for effective gene silencing in
Felix Sieber‐Schäfer, Min Jiang, Adrian Kromer, Anny Nguyen, Müge Molbay, Simone Pinto Carneiro, David Jürgens, Gerald Burgstaller, Bastian Popper, Benjamin Winkeljann, Olivia Monika Merkel   +10 more
wiley   +1 more source

Identification of COVID-19 susceptibility genes by Mendelian randomization. [PDF]

Sci Prog
Wang H, Ma K, Wu J, Shan M, Zhang G.
europepmc   +1 more source

TLR7 and TLR8 Gene Variations and Susceptibility to Hepatitis C Virus Infection

, 2011
Chiou-Huey Wang, Hock‐Liew Eng, Kuei-Hsiang Lin, Cheng‐Hsien Chang, Chi-An Hsieh, Yen-Li Lin, Tsun‐Mei Lin   +6 more
openalex   +2 more sources

Perfusable Brain Microvascular Network‐On‐Chip Model to Study Flavivirus NS1‐Induced Endothelial Dysfunction

Advanced Functional Materials, EarlyView.
This study presents a microfluidic brain microvascular network‐on‐chip (BMVasChip) to investigate endothelial barrier dysfunction caused by flavivirus non‐structural protein 1 (NS1), including virus‐ and time‐dependent vascular damage, leakiness, and dysfunction.
Monika Rajput, Yen‐Ting Tung, Yu‐Chi Chen, Min Jae Song, Marc Ferrer, Emily M. Lee   +5 more
wiley   +1 more source

Association of inflammatory susceptibility genes with myopia in Chinese children. [PDF]

Int Ophthalmol
Liu X, Hu X, Zhen Y, Tao Y.
europepmc   +1 more source