Results 11 to 20 of about 503,154 (248)

Clustered Regularly Interspaced Short Palindromic Repeats-Associated Protein System for Resistance Against Plant Viruses: Applications and Perspectives

Frontiers in Plant Science, 2022
Different genome editing approaches have been used to engineer resistance against plant viruses. The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein (Cas; CRISPR/Cas) systems to create pinpoint genetic ...
Fredy D. A. Silva, Elizabeth P. B. Fontes   +1 more
doaj   +1 more source

Genetic Susceptibility of the Host in Virus-Induced Diabetes

Microorganisms, 2020
Enteroviruses, especially Coxsackie B viruses, are among the candidate environmental factors causative of type 1 diabetes. Host genetic factors have an impact on the development of virus-induced diabetes (VID).
Keiichiro Mine, Yasunobu Yoshikai, Hirokazu Takahashi, Hitoe Mori, Keizo Anzai, Seiho Nagafuchi   +5 more
doaj   +1 more source

Transcriptome-Wide Association Studies and Integration Analysis of mRNA Expression Profiles Identify Candidate Genes and Pathways Associated With Ankylosing Spondylitis

Frontiers in Immunology, 2022
This study aimed to identify susceptibility genes and pathways associated with ankylosing spondylitis (AS) by integrating whole transcriptome-wide association study (TWAS) analysis and mRNA expression profiling data.
Ruoyang Feng, Mengnan Lu, Lin Liu, Ke Xu, Peng Xu   +4 more
doaj   +1 more source

Mining Grapevine Downy Mildew Susceptibility Genes: A Resource for Genomics-Based Breeding and Tailored Gene Editing

Biomolecules, 2021
Several pathogens continuously threaten viticulture worldwide. Until now, the investigation on resistance loci has been the main trend to understand the interaction between grapevine and the mildew causal agents.
Carlotta Pirrello, Tieme Zeilmaker, Luca Bianco, Lisa Giacomelli, Claudio Moser, Silvia Vezzulli   +5 more
doaj   +1 more source

Influence of Nitrogen on Grapevine Susceptibility to Downy Mildew

Plants, 2023
Downy mildew, caused by the obligate parasite Plasmopara viticola, is one of the most important threats to viticulture. The exploitation of resistant and susceptibility traits of grapevine is one of the most promising ways to increase the sustainability ...
Demetrio Marcianò, Valentina Ricciardi, Giuliana Maddalena, Annamaria Massafra, Elena Marone Fassolo, Simona Masiero, Piero Attilio Bianco, Osvaldo Failla, Gabriella De Lorenzis, Silvia Laura Toffolatti   +9 more
doaj   +1 more source

Exploring New Routes for Genetic Resistances to Potyviruses: The Case of the Arabidopsis thaliana Phosphoglycerates Kinases (PGK) Metabolic Enzymes

Viruses, 2022
The development of recessive resistance by loss of susceptibility is a consistent strategy to combat and limit damages caused by plant viruses. Susceptibility genes can be turned into resistances, a feat that can either be selected among the plant’s ...
Mamoudou Diop, Jean-Luc Gallois
doaj   +1 more source

Inactivation of tomato WAT1 leads to reduced susceptibility to Clavibacter michiganensis through downregulation of bacterial virulence factors

Frontiers in Plant Science, 2023
Tomato bacterial canker caused by Clavibacter michiganensis (Cm) is considered to be one of the most destructive bacterial diseases of tomato. To date, no resistance to the pathogen has been identified. While several molecular studies have identified (Cm)
Eleni Koseoglou, Eleni Koseoglou, Katharina Hanika, Mas M. Mohd Nadzir, Wouter Kohlen, Jan M. van der Wolf, Richard G. F. Visser, Yuling Bai   +7 more
doaj   +1 more source

Single-Cell RNA Sequencing Reveals the Expansion of Cytotoxic CD4+ T Lymphocytes and a Landscape of Immune Cells in Primary Sjögren’s Syndrome

Frontiers in Immunology, 2021
ObjectivePrimary Sjögren’s syndrome (pSS) is a systemic autoimmune disease, and its pathogenetic mechanism is far from being understood. In this study, we aimed to explore the cellular and molecular mechanisms that lead to pathogenesis of this disease ...
Xiaoping Hong, Xiaoping Hong, Shuhui Meng, Donge Tang, Tingting Wang, Liping Ding, Haiyan Yu, Heng Li, Dongzhou Liu, Yong Dai, Min Yang   +10 more
doaj   +1 more source

The genetic basis of onset age in schizophrenia: evidence and models

Frontiers in Genetics, 2023
Schizophrenia is a heritable neurocognitive disorder affecting about 1% of the population, and usually has an onset age at around 21–25 in males and 25–30 in females.
Na Zhan, Pak C. Sham, Pak C. Sham, Pak C. Sham, Hon-Cheong So, Hon-Cheong So, Hon-Cheong So, Hon-Cheong So, Hon-Cheong So, Hon-Cheong So, Hon-Cheong So, Simon S. Y. Lui   +11 more
doaj   +1 more source

Family history of any cancer for childhood leukemia patients in Sweden

eJHaem, 2021
Acute lymphoblastic leukemia (ALL) is the most common childhood leukemia, while the other types, acute myeloid leukemia (AML), chronic lymphocytic leukemia (CLL), and chronic myeloid leukemia (CML) are much rarer.
Xinjun Li, Kristina Sundquist, Jan Sundquist, Asta Försti, Kari Hemminki   +4 more
doaj   +1 more source