Results 11 to 20 of about 6,323,337 (377)

Susceptibility Genes to Plant Viruses [PDF]

Viruses, 2018
Plant viruses use cellular factors and resources to replicate and move. Plants respond to viral infection by several mechanisms, including innate immunity, autophagy, and gene silencing, that viruses must evade or suppress. Thus, the establishment of infection is genetically determined by the availability of host factors necessary for virus replication
H. García-Ruíz
openaire   +4 more sources

Alternative polyadenylation transcriptome-wide association study identifies APA-linked susceptibility genes in brain disorders

Nature Communications, 2023
Alternative polyadenylation (APA) plays an essential role in brain development; however, current transcriptome-wide association studies (TWAS) largely overlook APA in nominating susceptibility genes.
Ya Cui, F. Arnold, Fanglue Peng, Dan Wang, J. Li, S. Michels, E. Wagner, A. L. La Spada, Wei Li   +8 more
semanticscholar   +1 more source

Exome sequencing identifies breast cancer susceptibility genes and defines the contribution of coding variants to breast cancer risk

Nature Genetics, 2023
Linkage and candidate gene studies have identified several breast cancer susceptibility genes, but the overall contribution of coding variation to breast cancer is unclear. To evaluate the role of rare coding variants more comprehensively, we performed a
N. Wilcox, M. Dumont, A. González-Neira, S. Carvalho, C. Beauparlant, M. Crotti, C. Luccarini, P. Soucy, S. Dubois, R. Núñez-Torres, G. Pita, E. Gardner, J. Dennis, M. Alonso, N. Álvarez, C. Baynes, Annie Claude, S. Desjardins, Heiko Becher, S. Behrens, M. Bolla, J. Castelao, J. Chang-Claude, S. Cornelissen, T. Dörk, C. Engel, M. Gago-Domínguez, P. Guénel, A. Hadjisavvas, E. Hahnen, Mikael Hartman, B. Herráez, A. Jung, R. Keeman, M. Kiechle, Jingmei Li, M. Loizidou, M. Lush, K. Michailidou, M. Panayiotidis, X. Sim, Soo-Hwang Teo, J. Tyrer, L. V. D. Kolk, Cecilia Wahlström, Qin Wang, J. Perry, J. Benítez, M. Schmidt, R. Schmutzler, Paul D. P. Pharoah, Arnaud Droit, A. Dunning, A. Kvist, P. Devilee, D. Easton, J. Simard, Á. Carracedo, V. M. Garzón, Alejandro Novo Domínguez, María Elena Martínez, S. Ponte, Maite Carmen Redondo Marey, Peña Fernández, M. E. Castelo, Maria J. Torres, M. Calaza, J. Antúnez, Máximo Fraga   +68 more
semanticscholar   +1 more source

Pathology of Tumors Associated With Pathogenic Germline Variants in 9 Breast Cancer Susceptibility Genes

JAMA Oncology, 2022
Key Points Question What breast tumor characteristics are associated with rare pathogenic protein truncating or missense variants in breast cancer susceptibility genes?
N. Mavaddat, L. Dorling, S. Carvalho, Jamie Allen, A. González-Neira, R. Keeman, M. Bolla, J. Dennis, Qin Wang, T. Ahearn, I. Andrulis, M. Beckmann, S. Behrens, J. Benítez, M. Bermisheva, C. Blomqvist, N. Bogdanova, S. Bojesen, I. Briceño, T. Brüning, N. Camp, A. Campbell, J. Castelao, J. Chang-Claude, S. Chanock, G. Chenevix-Trench, Hans Christiansen, K. Czene, T. Dörk, M. Eriksson, D. Evans, P. Fasching, J. Figueroa, H. Flyger, M. Gabrielson, M. Gago-Domínguez, J. Geisler, G. Giles, P. Guénel, A. Hadjisavvas, E. Hahnen, P. Hall, U. Hamann, Jaana M. Hartikainen, M. Hartman, Reiner Hoppe, A. Howell, A. Jakubowska, A. Jung, E. Khusnutdinova, V. Kristensen, Jingmei Li, S. Lim, A. Lindblom, M. Loizidou, A. Lophatananon, J. Lubiński, Michael J. Madsen, A. Mannermaa, M. Manoochehri, S. Margolin, D. Mavroudis, R. Milne, N. A. Mohd Taib, A. Morra, K. Muir, N. Obi, A. Osorio, T. Park-Simon, P. Peterlongo, P. Radice, E. Saloustros, E. Sawyer, R. Schmutzler, M. Shah, X. Sim, M. Southey, H. Thorne, I. Tomlinson, Diana Torres, Thérèse Truong, C. Yip, A. Spurdle, M. Vreeswijk, A. Dunning, M. García-Closas, P. Pharoah, A. Kvist, T. Muranen, H. Nevanlinna, S. Teo, P. Devilee, M. Schmidt, D. Easton   +93 more
semanticscholar   +1 more source

Mutations introduced in susceptibility genes through CRISPR/Cas9 genome editing confer increased late blight resistance in potatoes

Scientific Reports, 2021
The use of pathogen-resistant cultivars is expected to increase yield and decrease fungicide use in agriculture. However, in potato breeding, increased resistance obtained via resistance genes (R-genes) is hampered because R-gene(s) are often specific ...
N. P. Kieu, M. Lenman, E. Wang, B. Petersen, E. Andreasson   +4 more
semanticscholar   +1 more source

Susceptibility genes of hyperuricemia and gout

Hereditas, 2022
Gout is a chronic metabolic disease that seriously affects human health. It is also a major challenge facing the world, which has brought a heavy burden to patients and society. Hyperuricemia (HUA) is the most important risk factor for gout.
Yueli Nian, Chong-Ge You
semanticscholar   +1 more source

ALS susceptibility genes [PDF]

Nature Genetics, 2015
K. Vogan
openaire   +2 more sources

Genomic Analysis Highlights Putative Defective Susceptibility Genes in Tomato Germplasm

Plants, 2023
Tomato (Solanum lycopersicum L.) is one of the most widely grown vegetables in the world and is impacted by many diseases which cause yield reduction or even crop failure.
Ruiling Li, Alex Maioli, Sergio Lanteri, Andrea Moglia, Yuling Bai, Alberto Acquadro   +5 more
doaj   +1 more source

Frequency of Pathogenic Germline Variants in Cancer-Susceptibility Genes in Patients With Osteosarcoma.

JAMA Oncology, 2020
Importance Osteosarcoma, the most common malignant bone tumor in children and adolescents, occurs in a high number of cancer predisposition syndromes that are defined by highly penetrant germline mutations.
L. Mirabello, Bin Zhu, R. Koster, E. Karlins, M. Dean, M. Yeager, Matthew Gianferante, L. Spector, L. Morton, D. Karyadi, L. Robison, G. Armstrong, S. Bhatia, Lei Song, N. Pankratz, M. Pinheiro, J. Gastier-Foster, R. Gorlick, S. D. de Toledo, A. Petrilli, A. Patiño-García, F. Lecanda, Miriam Gutiérrez-Jimeno, M. Serra, C. Hattinger, P. Picci, K. Scotlandi, A. Flanagan, R. Tirabosco, M. F. Amary, N. Kurucu, İ. İlhan, M. Ballinger, David M. Thomas, D. Barkauskas, G. Mejía-Baltodano, Patricia Valverde, B. Hicks, Bin Zhu, Mingyi Wang, A. Hutchinson, M. Tucker, J. Sampson, M. Landi, N. Freedman, S. Gapstur, B. Carter, R. Hoover, S. Chanock, S. Savage   +49 more
semanticscholar   +1 more source

Clustered Regularly Interspaced Short Palindromic Repeats-Associated Protein System for Resistance Against Plant Viruses: Applications and Perspectives

Frontiers in Plant Science, 2022
Different genome editing approaches have been used to engineer resistance against plant viruses. The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein (Cas; CRISPR/Cas) systems to create pinpoint genetic ...
Fredy D. A. Silva, Elizabeth P. B. Fontes   +1 more
doaj   +1 more source