Results 241 to 250 of about 930,320 (303)

Machine‐Learning Decomposition Identifies a Big Two Structure in Human Personality with Distinct Neurocognitive Profiles

Advanced Science, EarlyView.
Using machine learning on a mega‐scale global dataset (n = 1,336,840) reveals a robust personality trait architecture beyond the Big Five. A Big Two model, broadly capturing social engagement and internal mentation, defines a geometric space that links personality to neurocognitive profiles.
Kaixiang Zhuang, Ji Chen, Jinfeng Han, Wei Cheng, Jiang Qiu, Jianfeng Feng, Simon Eickhoff, Deniz Vatansever   +7 more
wiley   +1 more source

Recontact and follow-up for individuals with germline pathogenic variants in hereditary breast and ovarian cancer susceptibility genes: a UK Cancer Genetics Group consensus meeting. [PDF]

J Med Genet
Christopher J, Edgerley K, McIldowie B, Jewell R, Kemp Z, Snape K, Hanson H, Consensus meeting attendees.   +7 more
europepmc   +1 more source

A Bifunctional T3SS‐Effector Simultaneously Cleaves Host MAP Kinase and Inhibits PPM1A Phosphatase

Advanced Science, EarlyView.
Pathogenic bacteria exploit the metalloprotease effector NleD to subvert host defenses. Structural, biochemical, and infection analyses reveal a bifunctional mechanism by which NleD binds and inhibits the host phosphatase PPM1A while preserving its proteolytic activity against MAPKs.
Yaakov Socol, Lihi Gur‐Arie, Netanel Tzarum, Tamara Wellins, Naama Katsowich, Miriam Ravins, Michal Bejerano‐Sagie, Klil Cohen, Oded Livnah, Joshua N. Adkins, Ernesto Nakayasu, Alexei Savchenko, Yeu Khai Choong, Nikhil Kumar Tulsian, Saturo Machida, Sigal Ben‐Yehuda, Yael Litvak, J. Sivaraman, Ilan Rosenshine   +18 more
wiley   +1 more source

Gastric cancer susceptibility genes

World Chinese Journal of Digestology, 2014
openaire   +1 more source

Rate of germline pathogenic sequence variants in cancer susceptibility genes in an Israeli pediatric and adolescent cancer cohort: a single institute experience. [PDF]

Fam Cancer
Nahom D, Frenkel Z, Toren A, Friedman E, Kventsel I.   +4 more
europepmc   +1 more source

A broken network of susceptibility genes in the monocytes of Crohn's disease patients. [PDF]

Life Sci Alliance
Liu H, Guan L, Su X, Zhao L, Shu Q, Zhang J.   +5 more
europepmc   +1 more source

A Cross-Tissue Transcriptome-Wide Association Study Reveals Novel Susceptibility Genes for Diabetic Kidney Disease in the FinnGen Cohort. [PDF]

Biomedicines
Liu M, Li Z, Lu Y, Sun P, Chen Y, Yang L.   +5 more
europepmc   +1 more source

Integrating genetics and transcriptomics to decipher susceptibility genes for risk stratification of gastric cancer and effect modification of Helicobacter pylori treatment. [PDF]

EBioMedicine
Yin ZY, Xu HM, Wang MY, Wang XL, Liu ZC, Jin Y, Zhang Y, Zhang JY, Zhou T, You WC, Pan KF, Li WQ.   +11 more
europepmc   +1 more source

Correction: Characterization of the epidemiology, susceptibility genes and clinical features of viral infections among children with inborn immune errors: a retrospective study. [PDF]

Virol J
Zhang H, Wang W, Zhou Q, Hou J, Ying W, Hui X, Sun J, Liu L, Liu L, Wang C, Zhang H, Sun B, Wang X.   +12 more
europepmc   +1 more source

Trans-ancestry transcriptome-wide association and functional studies to uncover novel susceptibility genes and therapeutic targets for colorectal cancer. [PDF]

NPJ Precis Oncol
Wang L, Hu L, Sun J, Zhao J, Zhou S, Liu L, Yu W, Hu Y, Zhou D, Meng X, Yuan Z, Zhang H, Farrington S, Timofeeva M, Ding K, Little J, Dunlop M, Theodoratou E, Li X.   +18 more
europepmc   +1 more source