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Susceptibility Genes in Hypertension
Current Pharmaceutical Design, 2011Hypertension is a complex, multifactorial disease; genetic factors represent one third to half of the inter-individual variability of blood pressure values. Among the causes of secondary hypertension are a group of disorders with a Mendelian inheritance pattern. Recent advances in molecular biology have revealed the pathogenesis of hypertension in many
C, Armani, N, Botto, M G, Andreassi
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The RAD30 cancer susceptibility gene
Biochemical Society Transactions, 2003The human skin cancer-prone disease xeroderma pigmentosum variant (XPV) results from a mutation in RAD30, which encodes the novel lesion bypass DNA polymerase η. XPV cells are characterized by delayed completion of DNA replication and increased mutagenesis following UV irradiation.
Carty, M.P. +8 more
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Human Retinoblastoma Susceptibility Gene
1990It is clear that the RB-deficient tumor cells lost their tumorigenicity in nude mice after regaining the RB gene expression. However, the mechanism of tumor suppression by the RB gene is still unknown. More studies on the biological activities of RB protein, pp110RB, are necessary to answer this question.
C C, Lai, W H, Lee
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FINDING PROSTATE CANCER SUSCEPTIBILITY GENES
Annual Review of Genomics and Human Genetics, 2004▪ Abstract Prostate cancer is a heterogeneous disease with multiple loci contributing to susceptibility. Traditionally, genome-wide scans using high-risk families have utilized stratification by number of affected individuals, family history of other cancers, or family age at diagnosis to improve genetic homogeneity.
Elaine A, Ostrander +2 more
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Susceptibility Genes in Human Epilepsy
Seminars in Neurology, 1999Major advances in the identification of genetic loci and genes that predispose individuals to epilepsy have been made in the last several years. Two main themes for human, idiopathic epilepsies are emerging; genetic, or locus heterogeneity is not uncommon, and the discovery that epilepsy susceptibility genes are voltage-gated and ligand-gated ion ...
M F, Leppert, N, Singh
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Susceptibility genes in movement disorders
Movement Disorders, 2008AbstractDuring the last years, remarkable progress in our understanding of molecular genetic mechanisms underlying movement disorders has been achieved. The successes of linkage studies, followed by positional cloning, have dominated the last decade and several genes underlying monogenic disorders have been discovered. The pathobiological understanding
Sonja, Scholz, Andrew, Singleton
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Nihon rinsho. Japanese journal of clinical medicine, 1999
Non-insulin dependent diabetes mellitus (NIDDM) is a heterogeneous disorder and both genetic and nongenetic factors are associated with the development of diabetes. Until now five genes (HNF-4 alpha, glucokinase, HNF-1 alpha, IPF-1 and HNF-1 beta), whose mutation can result in MODY, insulin and insulin receptor genes, and mitochondria DNA have been ...
H, Furuta, T, Sanke, K, Nanjo
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Non-insulin dependent diabetes mellitus (NIDDM) is a heterogeneous disorder and both genetic and nongenetic factors are associated with the development of diabetes. Until now five genes (HNF-4 alpha, glucokinase, HNF-1 alpha, IPF-1 and HNF-1 beta), whose mutation can result in MODY, insulin and insulin receptor genes, and mitochondria DNA have been ...
H, Furuta, T, Sanke, K, Nanjo
openaire +1 more source