Results 271 to 280 of about 583,132 (315)

Susceptibility Genes in Hypertension

Current Pharmaceutical Design, 2011
Hypertension is a complex, multifactorial disease; genetic factors represent one third to half of the inter-individual variability of blood pressure values. Among the causes of secondary hypertension are a group of disorders with a Mendelian inheritance pattern. Recent advances in molecular biology have revealed the pathogenesis of hypertension in many
C, Armani, N, Botto, M G, Andreassi
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The RAD30 cancer susceptibility gene

Biochemical Society Transactions, 2003
The human skin cancer-prone disease xeroderma pigmentosum variant (XPV) results from a mutation in RAD30, which encodes the novel lesion bypass DNA polymerase η. XPV cells are characterized by delayed completion of DNA replication and increased mutagenesis following UV irradiation.
Carty, M.P., Glynn, M., Maher, M., Smith, T., Yao, J., Dixon, K., McCann, J., Rynn, L., Flanagan, A.   +8 more
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Genes and Susceptibility to Leishmaniasis

2005
Leishmania are digenetic protozoa which inhabit two highly specific hosts, the sandfly where they grow as motile, flagellated promastigotes in the gut, and the mammalian macrophage where they grow intracellularly as non-flagellated amastigotes. Leishmaniasis is the outcome of an evolutionary 'arms race' between the host's immune system and the parasite'
Emanuela, Handman, Colleen, Elso, Simon, Foote   +2 more
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The insulin gene and susceptibility to IDDM

Genetic Epidemiology, 1989
AbstractThe association between insulin‐dependent diabetes mellitus (IDDM) and an allele of a restriction fragment length polymorphism (RFLP) 5′ to the coding region of the insulin gene has raised the possibility that variation in the vicinity of the insulin gene confers susceptibility to IDDM.
N J, Cox, R S, Spielman
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Genes of Susceptibility to Cancer

Hormone Research, 2008
As opposed to dominantly-acting oncogenes, antioncogenes represent a new class of tumor suppressor genes, the prototype of which is the gene for retinoblastoma. Hereditary predisposition to cancer can be due to alteration of one copy of an antioncogene, while a tumor will develop only when the second copy is altered by a somatic mutation.
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Susceptibility Genes in Human Epilepsy

Seminars in Neurology, 1999
Major advances in the identification of genetic loci and genes that predispose individuals to epilepsy have been made in the last several years. Two main themes for human, idiopathic epilepsies are emerging; genetic, or locus heterogeneity is not uncommon, and the discovery that epilepsy susceptibility genes are voltage-gated and ligand-gated ion ...
M F, Leppert, N, Singh
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Human Retinoblastoma Susceptibility Gene

1990
It is clear that the RB-deficient tumor cells lost their tumorigenicity in nude mice after regaining the RB gene expression. However, the mechanism of tumor suppression by the RB gene is still unknown. More studies on the biological activities of RB protein, pp110RB, are necessary to answer this question.
C C, Lai, W H, Lee
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The CYP1A1 gene and cancer susceptibility

Critical Reviews in Oncology/Hematology, 1993
A close correlation between cigarette smoking associated lung cancer incidence and an Msp I restriction fragment length polymorphism (RFLP) of the human P-450 1A1 (CYP1A1) gene was found in a Japanese population in terms of genotype frequency and cigarette dose.
K, Kawajiri, K, Nakachi, K, Imai, J, Watanabe, S, Hayashi   +4 more
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In search of susceptibility genes for schizophrenia

Wiener klinische Wochenschrift, 2004
After the recent discovery and replication of several schizophrenia candidate regions on multiple chromosomes, susceptibility genes for schizophrenia could be identified for the first time. Each of these discoveries resulted from association studies within chromosomal regions first identified by linkage analyses.
Alexandra, Schosser, Harald N, Aschauer
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Susceptibility Genes for Breast Cancer

New England Journal of Medicine, 1994
In an era in which the importance of a scientific advance often appears to be measured by the amount of media coverage it generates, the level of reporting of the recent identification of BRCA1, a ...
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