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Susceptibility genes in movement disorders
Movement Disorders, 2008AbstractDuring the last years, remarkable progress in our understanding of molecular genetic mechanisms underlying movement disorders has been achieved. The successes of linkage studies, followed by positional cloning, have dominated the last decade and several genes underlying monogenic disorders have been discovered. The pathobiological understanding
Sonja, Scholz, Andrew, Singleton
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Searching for susceptibility genes in schizophrenia
European Neuropsychopharmacology, 2001The existence of an important genetic contribution to the aetiology of schizophrenia is well established from genetic epidemiological studies. However, the mode of transmission is complex and non-Mendelian. The main approaches used to identify susceptibility genes are linkage and association studies and the study of cytogenetic abnormalities associated
I, Jurewicz +3 more
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Approaches to the identification of susceptibility genes
Parasite Immunology, 2009SUMMARY Although previous studies have revealed a great deal about the genetic basis of susceptibility and resistance to parasite infection, there is now an opportunity to considerably enhance understanding through genome‐wide association mapping. The application of association mapping to complex inheritance has recently become achievable given reduced
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Cytokine genes and disease susceptibility
Cytokine, 2004Complex networks of cytokines interact in a dynamic way to homeostatically regulate immune responses and other biological pathways. It is, therefore, not surprising that variation in cytokine level has been correlated with disease susceptibility and process.
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Susceptibility genes in asthma and allergy
Current Allergy and Asthma Reports, 2001Genome-wide screens for asthma and atopy susceptibility loci have been completed in six population samples. Despite the extensive clinical heterogeneity associated with these phenotypes, 20 chromosomal regions show evidence of linkage (P < 0.01) in three or more population samples.
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Susceptibility genes in severe asthma
Current Allergy and Asthma Reports, 2006Asthma is a common complex disease with a very wide spectrum of severity. Although part of this may be due to differing environmental interactions and inadequate treatment, there is increasing evidence that in addition to susceptibility genes for asthma onset, there are also important genetic influences over the disease severity, response to treatment,
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Susceptibility Is New Resistance: Wheat Susceptibility Genes and Exploitation in Resistance Breeding
Agriculture (Switzerland), 2022Cheng Chang
exaly
Genes and susceptibility to multiple sclerosis
Acta Neurologica Scandinavica, 1995D A, Compston +4 more
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