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TNF susceptibility-related gene expression
Immunology Letters, 1991A series of BWL hybridoma lines has been generated by cell fusion of a TNF-resistant BW5147 cell line and a highly TNF-sensitive WR19L cell line, and has exhibited a wide variety of TNF susceptibility. A cDNA library, BWL47rp10, from a TNF-susceptible hybridoma line BWL47 has been screened by hybridization with a 32P-labeled subtraction cDNA probe from
T, Kinebuchi, H, Nishimura, T, Yoshida
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Genes and Susceptibility to Leishmaniasis
2005Leishmania are digenetic protozoa which inhabit two highly specific hosts, the sandfly where they grow as motile, flagellated promastigotes in the gut, and the mammalian macrophage where they grow intracellularly as non-flagellated amastigotes. Leishmaniasis is the outcome of an evolutionary 'arms race' between the host's immune system and the parasite'
Emanuela, Handman +2 more
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Susceptibility Genes for Breast Cancer
New England Journal of Medicine, 1994In an era in which the importance of a scientific advance often appears to be measured by the amount of media coverage it generates, the level of reporting of the recent identification of BRCA1, a ...
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Cytokine genes and disease susceptibility
Cytokine, 2004Complex networks of cytokines interact in a dynamic way to homeostatically regulate immune responses and other biological pathways. It is, therefore, not surprising that variation in cytokine level has been correlated with disease susceptibility and process.
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Susceptibility genes in severe asthma
Current Allergy and Asthma Reports, 2006Asthma is a common complex disease with a very wide spectrum of severity. Although part of this may be due to differing environmental interactions and inadequate treatment, there is increasing evidence that in addition to susceptibility genes for asthma onset, there are also important genetic influences over the disease severity, response to treatment,
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Genes of Susceptibility to Cancer
Hormone Research, 1989As opposed to dominantly-acting oncogenes, antioncogenes represent a new class of tumor suppressor genes, the prototype of which is the gene for retinoblastoma. Hereditary predisposition to cancer can be due to alteration of one copy of an antioncogene, while a tumor will develop only when the second copy is altered by a somatic mutation.
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[Diabetes susceptibility genes].
Nihon rinsho. Japanese journal of clinical medicine, 2009Type 2 diabetes mellitus is a complex polygenic disorder in which common genetics variants interact with environmental factors. Genome-wide association study(GWAS) revealed more than 10 diabetes susceptibility loci for type 2 diabetes mellitus including SNPs in KCNQ1, which was first identified in Japanese by two independent Japanese groups.
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Genes Controlling Susceptibility to Mammary Cancer.
1999Abstract : Oral gavage with the carcinogen 7,l2-dimethylbenzAanthracene (DMBA) is reported to specifically cause mammary tumors in rats. This work examined the response of different genotypes of mice to this carcinogen. Mice demonstrate a genotypic specificity for the particular tumors that they develop; DMBA increase the incidence of and decreases the
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