Results 21 to 30 of about 6,323,337 (377)

Gene–gene interactions in breast cancer susceptibility [PDF]

Human Molecular Genetics, 2011
There have been few definitive examples of gene-gene interactions in humans. Through mutational analyses in 7325 individuals, we report four interactions (defined as departures from a multiplicative model) between mutations in the breast cancer susceptibility genes ATM and CHEK2 with BRCA1 and BRCA2 (case-only interaction between ATM and BRCA1/BRCA2 ...
Turnbull C, Seal S, Renwick A, Warren-Perry M, Hughes D, Elliott A, Pernet D, Peock S, Adlard JW, Barwell J, Berg J, Brady AF, Brewer C, Brice G, Chapman C, Cook J, Davidson R, Donaldson A, Douglas F, Greenhalgh L, Henderson A, Izatt L, Kumar A, Lalloo F, Miedzybrodzka Z, Morrison PJ, Paterson J, Porteous M, Rogers MT, Shanley S, Walker L, Ahmed M, Eccles D, Evans DG, Donnelly P, Easton DF, Stratton MR, Rahman N, Breast Canc Susceptibility, EMBRACE   +39 more
openaire   +7 more sources

A strong immune response in young adult honeybees masks their increased susceptibility to infection compared to older bees [PDF]

, 2012
Honeybees, Apis mellifera, show age-related division of labor in which young adults perform maintenance ("housekeeping") tasks inside the colony before switching to outside foraging at approximately 23 days old. Disease resistance is an important feature
Baxter, Laura, Bull, James C., Chandler, Dave, Mead, A. (Andrew), Osborne, Juliet L., Pell, Judith K., Prince, Gillian, Ryabov, Eugene V., Zhang, Cunjin   +8 more
core   +9 more sources

Identifying novel susceptibility genes for colorectal cancer risk from a transcriptome-wide association study of 125,478 subjects.

Gastroenterology, 2020
BACKGROUND AND AIMS Susceptibility genes and the underlying mechanisms for the majority of risk loci identified by genome-wide association studies (GWAS) for colorectal cancer (CRC) risk remain largely unknown.
Xingyi Guo, Weiqiang Lin, W. Wen, J. Huyghe, Stephanie A. Bien, Q. Cai, T. Harrison, Zhishan Chen, C. Qu, Jiandong Bao, J. Long, Yuan Yuan, Fangqin Wang, Mengqiu Bai, G. Abecasis, D. Albanes, S. Berndt, S. Bézieau, D. Bishop, H. Brenner, S. Buch, A. Burnett-Hartman, P. Campbell, S. Castellví-Bel, A. T. Chan, A. T. Chan, J. Chang-Claude, S. Chanock, Sang‐Hee Cho, D. Conti, A. Chapelle, E. Feskens, S. Gallinger, Graham G. Giles, Graham G. Giles, P. Goodman, A. Gsur, Mark A Guinter, M. Gunter, J. Hampe, H. Hampel, R. Hayes, M. Hoffmeister, E. Kampman, H. Kang, T. Keku, H. Kim, L. Marchand, Soo-Chin Lee, Christopher I. Li, Li Li, A. Lindblom, A. Lindblom, N. Lindor, R. Milne, R. Milne, V. Moreno, N. Murphy, Polly A Newcomb, Polly A Newcomb, D. Nickerson, K. Offit, K. Offit, R. Pearlman, P. Pharoah, E. Platz, J. Potter, G. Rennert, Lori C. Sakoda, Lori C. Sakoda, C. Schafmayer, S. Schmit, R. Schoen, F. Schumacher, M. Slattery, Yu-Ru Su, C. Tangen, C. Ulrich, F. V. Duijnhoven, B. Guelpen, K. Visvanathan, P. Vodicka, L. Vodickova, Veronika Vymetálková, Xiaolong Wang, Emily White, Emily White, A. Wolk, M. Woods, G. Casey, L. Hsu, M. Jenkins, S. Gruber, Ulrike Peters, Ulrike Peters, W. Zheng   +95 more
semanticscholar   +1 more source

Genetic Susceptibility of the Host in Virus-Induced Diabetes

Microorganisms, 2020
Enteroviruses, especially Coxsackie B viruses, are among the candidate environmental factors causative of type 1 diabetes. Host genetic factors have an impact on the development of virus-induced diabetes (VID).
Keiichiro Mine, Yasunobu Yoshikai, Hirokazu Takahashi, Hitoe Mori, Keizo Anzai, Seiho Nagafuchi   +5 more
doaj   +1 more source

Transcriptome-Wide Association Studies and Integration Analysis of mRNA Expression Profiles Identify Candidate Genes and Pathways Associated With Ankylosing Spondylitis

Frontiers in Immunology, 2022
This study aimed to identify susceptibility genes and pathways associated with ankylosing spondylitis (AS) by integrating whole transcriptome-wide association study (TWAS) analysis and mRNA expression profiling data.
Ruoyang Feng, Mengnan Lu, Lin Liu, Ke Xu, Peng Xu   +4 more
doaj   +1 more source

Association of the AFF3 gene and IL2/IL21 gene region with juvenile idiopathic arthritis [PDF]

, 2010
Recent genetic studies have led to identification of numerous loci that are associated with susceptibility to autoimmune diseases. The strategy of using information from these studies has facilitated the identification of novel juvenile idiopathic ...
Barton, A., British Society of Paediatric and Adolescent Rheumatology (BSPAR) Study Group, Childhood Arthritis Prospective Study (CAPS), Eyre, S., Flynn, E., Gardner-Medwin, J. [CAPS and BSPAR study groups], Hinks, A., Ke, X., Martin, P., Packham, J., Thomson, W., UKRAG Consortium, Worthington, J.   +12 more
core   +1 more source

Associations of clock genes polymorphisms with soft tissue sarcoma susceptibility and prognosis [PDF]

, 2018
BACKGROUND: Dysfunction of the circadian clock and polymorphisms of some circadian genes have been linked to cancer development and progression. We investigated the relationship between circadian genes germline variation and susceptibility or prognosis ...
Benna, Clara, Del Fiore, Paolo, Mocellin, Simone, Rajendran, Senthilkumar, Rossi, Carlo Riccardo, Spiro, Giovanna, Tropea, Saveria   +6 more
core   +2 more sources

Mining Grapevine Downy Mildew Susceptibility Genes: A Resource for Genomics-Based Breeding and Tailored Gene Editing

Biomolecules, 2021
Several pathogens continuously threaten viticulture worldwide. Until now, the investigation on resistance loci has been the main trend to understand the interaction between grapevine and the mildew causal agents.
Carlotta Pirrello, Tieme Zeilmaker, Luca Bianco, Lisa Giacomelli, Claudio Moser, Silvia Vezzulli   +5 more
doaj   +1 more source

Whole-Genome Sequencing and Concordance Between Antimicrobial Susceptibility Genotypes and Phenotypes of Bacterial Isolates Associated with Bovine Respiratory Disease. [PDF]

, 2017
Extended laboratory culture and antimicrobial susceptibility testing timelines hinder rapid species identification and susceptibility profiling of bacterial pathogens associated with bovine respiratory disease, the most prevalent cause of cattle ...
Abdo, Zaid, Aly, Sharif S, Belk, Keith, Blanchard, Patricia C, Davis, Jessica H, Lehenbauer, Terry W, Miller, Michael R, Morley, Paul, Noyes, Noelle, O'Rourke, Sean M, Owen, Joseph R, Prince, Daniel J, Van Eenennaam, Alison L, Young, Amy E   +13 more
core   +2 more sources

Searching for "monogenic diabetes" in dogs using a candidate gene approach [PDF]

, 2014
BACKGROUND: Canine diabetes is a common endocrine disorder with an estimated breed-related prevalence ranging from 0.005% to 1.5% in pet dogs. Increased prevalence in some breeds suggests that diabetes in dogs is influenced by genetic factors and ...
Catchpole, B, Holder, A L, Kennedy, L J, Massey, J, Ollier, W E R, Rothwell, S, Scholey, R, Short, A D   +7 more
core   +3 more sources