Results 51 to 60 of about 503,154 (248)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

An xa5 Resistance Gene-Breaking Indian Strain of the Rice Bacterial Blight Pathogen Xanthomonas oryzae pv. oryzae Is Nearly Identical to a Thai Strain

Frontiers in Microbiology, 2020
The rice bacterial blight pathogen Xanthomonas oryzae pv. oryzae (Xoo) constrains production in major rice growing countries of Asia. Xoo injects transcription activator-like effectors (TALEs) that bind to and activate host “susceptibility” (S) genes ...
Sara C. D. Carpenter, Prashant Mishra, Chandrika Ghoshal, Prasanta K. Dash, Li Wang, Samriti Midha, Gouri S. Laha, Jagjeet S. Lore, Wichai Kositratana, Nagendra K. Singh, Kuldeep Singh, Prabhu B. Patil, Ricardo Oliva, Sujin Patarapuwadol, Adam J. Bogdanove, Rhitu Rai   +15 more
doaj   +1 more source

Prioritization of candidate causal genes for asthma in susceptibility loci derived from UK Biobank [PDF]

, 2021
Kim Valette, Zhonglin Li, Valentin Bon-Baret, Arnaud Chignon, Jean‐Christophe Bérubé, Aïda Eslami, Jennifer Lamothe, Nathalie Gaudreault, Philippe Joubert, Ma’en Obeidat, Maarten van den Berge, Wim Timens, Don D. Sin, David C. Nickle, Ke Hao, Catherine Labbé, Krystelle Godbout, Andréanne Côté, Michel Laviolette, Louis‐Philippe Boulet, Patrick Mathieu, Sébastien Thériault, Yohan Bossé   +22 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Editorial: Genetic features contributing to eye development and disease

Frontiers in Cell and Developmental Biology, 2022
Wenchang Xu, Xinqi Liu, Xinqi Liu, Wenjuan Han, Ling Zhao   +4 more
doaj   +1 more source

Transcriptional profiling of Impatiens walleriana genes through different stages of downy mildew infection reveals novel genes involved in disease susceptibility

Ornamental Plant Research
Impatiens downy mildew is a highly destructive disease of Impatiens walleriana, an economically important bedding ornamental crop. This disease is caused by a recently emerged pathogen Plasmopara obducens.
Stephanie Suarez, Zunaira Afzal Naveed, Gul Shad Ali   +2 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Vitamin D receptor gene polymorphism and polycystic ovary syndrome susceptibility [PDF]

, 2023
Ibrahim A Albahlol, Mustafa Neamatallah, Mohamed Saad Serria, Abdel‐Hady El‐Gilany, Yomna A Setate, Nashwa M. Alkasaby, Sally Abdallah Mostafa, Mahmoud Abdel-Aziz, Hossam El‐Azab, Omar A. Ammar   +9 more
openalex   +1 more source