Results 61 to 70 of about 6,323,337 (377)

Identification of Susceptibility Genes in Castanea sativa and Their Transcription Dynamics following Pathogen Infection

Plants, 2021
Castanea sativa is one of the main multipurpose tree species valued for its timber and nuts. This species is susceptible to two major diseases, ink disease and chestnut blight, caused by Phytophthora spp. and Cryphonectria parasitica, respectively.
Vera Pavese, Andrea Moglia, Paolo Gonthier, Daniela Torello Marinoni, Emile Cavalet-Giorsa, Roberto Botta   +5 more
doaj   +1 more source

The pmrCAB Operon Mediates Polymyxin Resistance In Acinetobacter Baumannii ATCC 17978 And Clinical Isolates Through Phosphoethanolamine Modification Of Lipid A [PDF]

, 2011
The emergence of multidrug resistance among Acinetobacter baumannii is leading to an increasing dependence on the use of polymyxins as last-hope antibiotics. Here, we utilized genetic and biochemical methods to define the involvement of the pmrCAB operon
Arroyo, Luis A., Fernandez, Lucia, Hancock, Robert E. W., Hankins, Jessica V., Herrera, Carmen M., Trent, M. Stephen   +5 more
core   +2 more sources

Research Progress on Genetic Susceptibility to Triple-Negative Breast Cancer

Zhongliu Fangzhi Yanjiu, 2023
Triple-negative breast cancer (TNBC) is a type of breast cancer that is difficult to treat, has a poor prognosis, and is prone to recurrence and metastasis in the early postoperative period.
ZHANG Lijia, LIU Jiarui, ZHANG Yuan, CHEN Xinyu, WANG Xin, ZHANG Yi   +5 more
doaj   +1 more source

The contribution of pathogenic variants in breast cancer susceptibility genes to familial breast cancer risk

npj Breast Cancer, 2017
Understanding the gene-specific risks for development of breast cancer will lead to improved clinical care for those carrying germline mutations in cancer predisposition genes.
T. Slavin, K. Maxwell, J. Lilyquist, J. Vijai, S. Neuhausen, S. Hart, Vignesh Ravichandran, Tinu Elizabeth Thomas, Ann Maria, D. Villano, K. Schrader, R. Moore, Chunling Hu, B. Wubbenhorst, Brandon M. Wenz, K. D’Andrea, M. Robson, P. Peterlongo, B. Bonanni, J. Ford, J. Garber, S. Domchek, C. Szabo, K. Offit, K. Nathanson, J. Weitzel, F. Couch   +26 more
semanticscholar   +1 more source

Associations of genetic variants contributing to gut microbiota composition in diabetic nephropathy

Frontiers in Endocrinology, 2023
IntroductionThe gut microbiota is strongly associated with multiple kidney diseases, and since microbial composition is heritable, we hypothesized that genetic variations controlling gut microbiota composition were associated with diabetic nephropathy ...
Xiao Lu, Junjun Ma, Lili Guo, Wei Wu, Rongshan Li   +4 more
doaj   +1 more source

Interspecies DNA acquisition by a naturally competent Acinetobacter baumannii strain [PDF]

, 2019
The human pathogen Acinetobacter baumannii possesses high genetic plasticity and frequently acquires antimicrobial resistance genes. Here we investigated the role of natural transformation in these processes. Genomic DNA from different sources, including
Bahiense, Camila dos Santos, Bonomo, Robert A., Dotto, Cristian Marcelo, Fernandez, Jennifer, Iriarte, Andres, Melano, Roberto Gustavo, Montaña, Sabrina Daiana, Perez, Federico, Place, Kori, Ramirez, Maria Soledad, Soler Bistue, Alfonso J. C., Tolmasky, Marcelo E., Traglia, German Matias   +12 more
core   +1 more source

Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease

PLoS ONE, 2014
Background Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought to identify new susceptibility genes, using an
V. Escott-Price, C. Bellenguez, Li-San Wang, S. Choi, D. Harold, L. Jones, P. Holmans, A. Gerrish, Alexey Vedernikov, A. Richards, A. Destefano, J. Lambert, C. Ibrahim-Verbaas, A. Naj, R. Sims, G. Jun, J. Bis, G. Beecham, B. Grenier‐Boley, G. Russo, T. Thornton-Wells, N. Denning, A. Smith, V. Chouraki, C. Thomas, M. Ikram, D. Zélénika, B. Vardarajan, Y. Kamatani, Chiao-Feng Lin, H. Schmidt, B. Kunkle, M. Dunstan, M. Vronskaya, Andrew D. Johnson, A. Ruiz, M. Bihoreau, C. Reitz, F. Pasquier, P. Hollingworth, O. Hanon, A. Fitzpatrick, J. Buxbaum, D. Campion, P. Crane, C. Baldwin, T. Becker, V. Gudnason, C. Cruchaga, D. Craig, N. Amin, C. Berr, O. Lopez, P. D. De Jager, V. Deramecourt, J. Johnston, D. Evans, S. Lovestone, L. Letenneur, I. Hernández, D. Rubinsztein, G. Eiriksdottir, K. Sleegers, A. Goate, N. Fievet, M. Huentelman, M. Gill, K. Brown, M. Kamboh, L. Keller, P. Barberger‐Gateau, B. McGuinness, E. Larson, A. Myers, C. Dufouil, S. Todd, D. Wallon, S. Love, E. Rogaeva, J. Gallacher, P. George-Hyslop, J. Clarimón, A. Lleó, A. Bayer, D. Tsuang, Lei Yu, M. Tsolaki, P. Bossù, G. Spalletta, P. Proitsi, J. Collinge, S. Sorbi, Florentino Sanchez Garcia, Nick C Fox, J. Hardy, M. Naranjo, P. Bosco, R. Clarke, C. Brayne, D. Galimberti, E. Scarpini, U. Bonuccelli, M. Mancuso, G. Siciliano, S. Moebus, P. Mecocci, M. Zompo, W. Maier, H. Hampel, A. Pilotto, A. Frank‐García, F. Panza, V. Solfrizzi, P. Caffarra, B. Nacmias, W. Perry, M. Mayhaus, L. Lannfelt, H. Hakonarson, S. Pichler, M. Carrasquillo, M. Ingelsson, D. Beekly, V. Álvarez, F. Zou, O. Valladares, S. Younkin, E. Coto, K. Hamilton-Nelson, W. Gu, C. Razquín, P. Pastor, I. Mateo, M. Owen, K. Faber, P. Jonsson, O. Combarros, M. O’Donovan, L. Cantwell, H. Soininen, D. Blacker, S. Mead, T. Mosley, D. Bennett, T. Harris, L. Fratiglioni, C. Holmes, R. F. de Bruijn, P. Passmore, T. Montine, K. Bettens, J. Rotter, A. Brice, K. Morgan, T. Foroud, W. Kukull, D. Hannequin, J. Powell, M. Nalls, K. Ritchie, K. Lunetta, J. Kauwe, E. Boerwinkle, M. Riemenschneider, M. Boada, M. Hiltunen, E. Martin, R. Schmidt, D. Rujescu, J. Dartigues, R. Mayeux, C. Tzourio, A. Hofman, M. Nöthen, C. Graff, B. Psaty, J. Haines, M. Lathrop, M. Pericak-Vance, L. Launer, C. van Broeckhoven, L. Farrer, C. V. van Duijn, A. Ramírez, S. Seshadri, G. Schellenberg, P. Amouyel, Julie Williams   +187 more
semanticscholar   +1 more source

Pathogenic Germline PALB2 and RAD50 Variants in Patients With Relapsed Ewing Sarcoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Approximately 10% of patients with Ewing sarcoma (EwS) have pathogenic germline variants. Here, we report two cases: first, a novel germline pathogenic variant in partner and localizer of BRCA2 (PALB2) in a patient with a late EwS relapse. Its impact on homologous recombination is demonstrated, and breast cancer risk is discussed.
Molly Mack, A. Carolina Tufino, Mohd Azrin Jamalruddin, Sreya Dey, Yinghong Pan, Elina Mukherjee, Jessica D. Daley, Julia Meade, Mahmoud Aarabi, Lisa Maurer, James Cooper, Kara A. Bernstein, Kelly M. Bailey   +12 more
wiley   +1 more source

Cardiometabolic traits mediating the effect of education on the risk of DKD and CKD: a Mendelian randomization study

Frontiers in Nutrition
BackgroundBoth diabetic kidney disease (DKD) and chronic kidney disease (CKD) are more prevalent among individuals with lower levels of education in observational studies.
Yukai Wang, Mengmeng Chen, Lin Wang, Yonggui Wu, Yonggui Wu   +4 more
doaj   +1 more source

Eukaryotic translation initiation factor 4E family member nCBP facilitates the accumulation of TGB-encoding viruses by recognizing the viral coat protein in potato and tobacco

Frontiers in Plant Science, 2022
Due to their limited coding capacity, plant viruses have to depend on various host factors for successful infection of the host. Loss of function of these host factors will result in recessively inherited resistance, and therefore, these host factors are
Ruhao Chen, Ruhao Chen, Manhua Yang, Zhen Tu, Fangru Xie, Jiaru Chen, Tao Luo, Xinxi Hu, Bihua Nie, Changzheng He   +9 more
doaj   +1 more source