Results 71 to 80 of about 220,364 (303)

“Just” ecopreneurs: re-conceptualising green transitions and entrepreneurship [PDF]

, 2016
© 2016 Informa UK Limited, trading as Taylor & Francis Group. Economic, environmental, and social limits of the current capitalist mode of production have led to a rethinking and reconceptualisation of economic processes and models including the role ...
Affolderbach, Julia, Krueger, Rob
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

The politics of sustainability transitions [PDF]

Journal of Environmental Policy & Planning, 2016
Sustainability transitions are processes of fundamental social change in response to societal challenges (Grin, Rotmans, & Schot, 2010; Markard, Raven, & Truffer, 2012).
Avelino, F., Grin, J., Pel, B., Jhagroe, S.   +3 more
openaire   +3 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Comparing nuclear power trajectories in Germany and the UK: from ‘regimes' to ‘democracies’ in sociotechnical transitions and Discontinuities [PDF]

, 2015
This paper focuses on arguably the single most striking contrast in contemporary major energy politics in Europe (and even the developed world as a whole): the starkly differing civil nuclear policies of Germany and the UK. Germany is seeking entirely to
A Aliseda, A Bergek, A Blowers, A Corner, A Glaser, A Gramsci, A Held, A Hommels, A Lijphart, A Lijphart, A Lovins, A Massey, A Pegels, A Piening, A Schutz, A Sen, A Sen, A Smith, A Smith, A Smith, A Smith, A Smith, A Smith, A Stirling, A Stirling, A Stirling, A Verbruggen, Andy Stirling, B B F Wittneben, B Doherty, B Flyvbjerg, B Griffin, B Hancke, B K Sovacool, B K Sovacool, B K Sovacool, B K Sovacool, B Latour, B Turnheim, B Wynne, B Wynne, Bbc News, Blowers, Bvg Associates, C A Miller, C Barnett, C C R Penna, C Cottarelli, C Crouch, C Klessmann, C Kuzemko, C Li, C M Hendriks, C M Hendriks, C Mitchell, D Campbell, D Clements, D Elliott, D Haraway, D Harvey, D J Hess, D J Hess, D Jahn, D Jahn, D Johnson, D King, D P Mccormack, D Rucht, D Toke, D Toke, Decc, Decc, Decc, E F Borgatta, E Kahn, E Laclau, E Laclau, E Shove, E Shove, E Swyngedouw, Edf Energy, Enf Solar, Ewea, F Berkhout, F Berkhout, F Geels, F Geels, F Kern, F Kern, F Kern, F Kern, F Kern, F L�v�que, F Malerba, F W Geels, F W Geels, F W Geels, F W Geels, F W Geels, F W Geels, Ffree, G C Unruh, G Harris, G Hecht, G L Munck, G Mackerron, G Munk, G Resch, G Resch, G Ritzer, G Smith, G Strohmeier, G Verbong, G Verbong, G Winter, German Bundestag, Globalscan, Gns, H Chalmers, H E Normann, H Marcuse, H P Kitschelt, Hm Government, Hm Government, I Bailey, I Lovinfosse, I Welsh, Iaea, Ipsos Mori, Irena, J A Camilleri, J Allouche, J Byrne, J C Scott, J Deign, J Dewey, J Downing, J Grin, J Huenteler, J Jewell, J Lipp, J Markard, J Markard, J Meadowcroft, J Mecklin, J Nill, J Pligt, J R Josephson, J Rotmans, J S Dryzek, J Schot, J Wilson, K Barnham, K Bergeron, K Bickerstaff, K Bruninx, K Hartley, K Kleiner, K Pavitt, K Rogge, K Smith Stegen, L Arnold, L Baker, L Coenen, L Magnani, L Veneklasen, L Winner, L�v�que, M Berth�lemy, M Blyth, M Bookchin, M B�hlmann, M B�hlmann, M J Witkamp, M Leach, M Lenzen, M Lockwood, M Lockwood, M Lockwood, M Lynas, M M Smink, M Mazzucato, M Purdue, M R Fhg-Isi, M Schneider, M V Ramana, M Weber, Mod, N Carter, N E Hultman, N Guild, N Luhmann, N Marres, Nukem, O Renn, P Bourdieu, P Bradford, P Delrio, P Hall, P Hall, P Johnstone, P Linares, P Pierson, P Stegmaier, Philip Johnstone, R Cowan, R Cowell, R E H Sims, R Eckstein, R Edwards, R Kemp, R Kemp, R Milne, R Nelson, R Norris, R Raven, R Simon, R Yin, Renewableuk, Rip, Royce Rolls, S ?i?ek, S ?i?ek, S Ansari, S Jacobsson, S Jasanoff, S Jasanoff, S Jhagroe, S Lukes, S Squassoni, S Strunz, S Thomas, S Thomas, S Thomas, Schrader-Frechette, T Bijker, T Hughes, T O&apos, U J�rgensen, U K Germany, Urenco, V Lauber, V M Fthenakis, W Arthur, W L�tkenhorst, W Nuttall, W Patterson, W Patterson, W Rudig, W Walker, Y Peng, Y.-H Sun   +251 more
core   +1 more source

Collective Action and Social Innovation in the Energy Sector: A Mobilization Model Perspective [PDF]

, 2020
This conceptual paper applies a mobilization model to Collective Action Initiatives (CAIs) in the energy sector. The goal is to synthesize aspects of sustainable transition theories with social movement theory to gain insights into how CAIs mobilize to ...
Arrobbio, Osman, Candelise, Chiara, Delvaux, Sarah, Gilcrease, Winston, Gregg, Jay Sterling, Hansen, Meiken, Nyborg, Sophie, Padovan, Dario, Polo-Alvarez, Lucia, Saenz, Victor, Schwanitz, Valeria Jana, Sciullo, Alessandro, Wierling, August, Zeiss, Jan Pedro   +13 more
core   +5 more sources

Transitions to Sustainability [PDF]

, 2015
International ...
Mancebo, Francois, Sachs, Ignacy
openaire   +2 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

The value of theoretical multiplicity for steering transitions towards sustainability [PDF]

, 2009
Transition management, as a theory of directing structural societal changes towards sustainable system innovations, has become a major topic in scientific research over the last years.
Breeman, G.E., Dewulf, A., Pot, W.D., Termeer, C.J.A.M., Werkman, R.A.   +4 more
core   +1 more source

High-Tech Urban Agriculture in Amsterdam : An Actor Network Analysis [PDF]

, 2020
The agriculture and horticulture sector in the Netherlands is one of the most productive in the world. Although the sector is one of the most advanced and intense agricultural production systems worldwide, it faces challenges, such as climate change and ...
Carsjens, Gerrit J., Farhangi, Mohsen H., Turvani, Margherita E., van der Valk, Arnold   +3 more
core   +1 more source