Results 71 to 80 of about 1,458,706 (335)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

The Piggy Solution: Harnessing Food Waste for Sustainable Hog Farming

Global Challenges
The increasing global population and concomitant rise in food demand lead to significant challenges in sustainable agricultural practices and food waste management.
Matthew C. Ogwu, Catherine E. Hills, Silvana Pietrosemoli   +2 more
doaj   +1 more source

Product service systems in the automotive industry: An alternative business model for a sustainable satisfaction system [PDF]

, 2008
Copyright @ 2008 Brunel UniversityThe paper presents the intermediate results of an on-going research project called Vehicle Design Summit (VDS), run by an international Consortium of Universities coordinated by the MIT of Boston.
Ceschin, F, Vezzoli, C
core  

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

VOLUNTARY SIMPLICITY – SUSTAINABLE ALTERNATIVE TO OVERCONSUMPTION

Polityki Europejskie, Finanse i Marketing, 2015
Dobrowolna prostota (VS) dobrze wpisuje się w koncepcję konsumpcji zrównoważonej, ponieważ do jej zasad należy budowanie zrównoważonej ekonomicznie przyszłości, kształtowanie harmonijnych relacji między ludźmi oraz kreowanie i pielęgnowanie więzi z ...
Aleksandra Burgiel, Izabela Sowa, Jolanta Zrałek   +2 more
doaj   +2 more sources

Sustainable product development strategies: Business planning and performance implications [PDF]

, 2012
Copyright © 2012 by Institution of Mechanical Engineers. This is the author's accepted manuscript. The final published article is available from the link below.Manufacturing firms are under many financial and competitive pressures which focus attention ...
Aurich JC, Davis S, Jacques JJ, McDonough W, Piller FT, Pine BJ, Toffler A   +6 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Investigation of Thermal Stability of Mg₈₄Cu₁₆ as New Potential High-Temperature Phase Change Materials for Latent Heat Storagee

Proceedings
This work examines the thermal stability testing results of Mg84Cu16 as a new phase change material for its potential use in latent thermal energy storage systems for 488 °C transition temperatures.
Yassine El Karim, Abdessamad Faik, Yaroslav Grosu, Rachid Lbibb   +3 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source