Results 91 to 100 of about 1,850,484 (311)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Network dynamics reveal drought synchronization hubs in the Po River Basin

Scientific Reports
The intensifying climate crisis has exacerbated the frequency and severity of prolonged droughts, particularly in environmentally and socio-economically vulnerable climate change hot-spot regions.
Antonio Zinilli, Edmondo Di Giuseppe, Arianna Di Paola, Sara Quaresima, Massimiliano Pasqui   +4 more
doaj   +1 more source

Monitoring and Improving Aircraft Maintenance Processes Using IT Systems

Applied Sciences
Aircraft maintenance is a complex, multifaceted process that greatly benefits from IT systems designed to improve supervision, record keeping, and task management.
Andrzej Żyluk, Mariusz Zieja, Karol Kawka, Bartłomiej Główczyk   +3 more
doaj   +1 more source

Sustainability And Growth [PDF]

Chemical & Engineering News Archive, 2010
THIS WEEK’S cover story on sustainability focuses on a green supply chain—manufacturers who are working to ensure that the ingredients that go into their products are produced in a sustainable fashion by workers who are treated fairly. Senior Editor Melody Voith talked to four niche consumer-brand companies about their relationships with raw material ...
openaire   +1 more source

THE SUSTAINABLE GROWTH PARADIGM'S APPLICATION TO U.S. FARM BUSINESSES [PDF]

The sustainable growth paradigm is used to analyze aggregate output decisions across U.S. agricultural productions regions. Results show that the farm sector has adapted to positive or negative sustainable growth challenges (SGC) and that, from an ...
Escalante, Cesar L., Turvey, Calum G.
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Anatomy of climate change research in Italian doctoral dissertations using a machine learning approach

Scientific Reports
Climate change is one of the defining challenges of our time, yet little is known about how early-career researchers contribute to this field through doctoral research.
Antonio Zinilli, Giusy Giulia Tuccari, Francesco Poggi, Andrea Giovanni Nuzzolese, Misael Mongiovì, Lorenzo Giammei, Rocco Paolillo, Carmelo Fabio Longo, Miguel Ceriani, Sara Zuppiroli   +9 more
doaj   +1 more source

Equine-Assisted Experiential Learning: A Literature Review of Embodied Leadership Development in Organizational Behavior

Administrative Sciences
Background: Equine-assisted experiential learning (EAL) is an emerging approach that uses human–horse interactions to develop leadership skills through experiential methods. Purpose: This review synthesizes the literature on the role of EAL in developing
Rubentheran Sivagurunathan, Abdul Rahman bin S Senathirajah, Linkesvaran Sivagurunathan, Sayeeduzzafar Qazi, Rasheedul Haque   +4 more
doaj   +1 more source

Is China’s Growth Sustainable? [PDF]

A central pillar of the sustainability movement is the call to include environmental accounting in standard measures of economic performance. This increased transparency would, in principle, mitigate the temptation of economic managers and policy makers ...
Hua Wang, James Roumasset, Kimberly Burnett   +2 more
core  

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source