Results 71 to 80 of about 6,005,317 (331)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Multi-Objective Optimization of Machining Parameters for Multi-Pass CNC Turning to Minimize Carbon Emissions, Energy, Noise and Cost

Jurnal Teknik Industri, 2021
Global warming is a huge environmental issue today. This is due to the high level of world carbon emissions. The manufacturing process accounts for 30% of the world's carbon emissions production.
Bening Maulina Fittamami, Eko Pujiyanto, Yusuf Priyandari   +2 more
doaj   +1 more source

Hard Milling Process Based on Compressed Cold Air-Cooling Using Vortex Tube for Sustainable and Smart Manufacturing

Machines, 2023
Improving machining performance and meeting the requirements of sustainable production at the same time represents a major challenge for the metalworking industry and scientific community.
Luka Celent, Dražen Bajić, Sonja Jozić, Marko Mladineo   +3 more
doaj   +1 more source

Assessing carbon dioxide emission reduction potentials of improved manufacturing processes using multiregional input output frameworks [PDF]

, 2016
Evaluating innovative process technologies has become highly important within the last decades. As standard tools different Life Cycle Assessment methods have been established, which are continuously improved.
Burger, Mia, Chang, Ya-Ju, Fürstmann, Paul, Neugebauer, Sabrina, Pittner, Andreas, Radebach, Alexander, Rethmeier, Michael, Sproesser, Gunther, Steckel, Jan Christoph, Uhlmann, Eckart, Ward, Hauke   +10 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Sustainable Drilling Strategies for Rivet Hole Formation in Nickel-Based Alloys for Aeronautical Applications

Journal of Manufacturing and Materials Processing
The formation of rivet holes is a critical step in aeronautical assembly, as hole quality directly influences the fatigue resistance and structural reliability of riveted joints. Nickel-based alloys, such as Inconel 625, present additional challenges due
José Manuel Sáenz de Pipaón, Amabel García-Domínguez, Juan Claver, Eva María Rubio   +3 more
doaj   +1 more source

Multi-Objective Optimization of Energy Consumption and Surface Quality in Nanofluid SQCL Assisted Face Milling

Energies, 2019
Considering the significance of improving the energy efficiency, surface quality and material removal quantity of machining processes, the present study is conducted in the form of an experimental investigation and a multi-objective optimization.
Aqib Mashood Khan, Muhammad Jamil, Konstantinos Salonitis, Shoaib Sarfraz, Wei Zhao, Ning He, Mozammel Mia, GuoLong Zhao   +7 more
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Eco-efficient process based on conventional machining as an alternative technology to chemical milling of aeronautical metal skin panels [PDF]

, 2019
El fresado químico es un proceso diseñado para la reducción de peso de pieles metálicas que, a pesar de los problemas medioambientales asociados, se utiliza en la industria aeronáutica desde los años 50.
Sol Illana, Irene del
core  

Experimental evaluation into novel, low cost, modular PEMFC stack [PDF]

, 2012
Attribution-NonCommercial-NoDerivs 3.0 Unported (CC BY-NC-ND 3.0)The Polymer Electrolyte Membrane Fuel Cell (PEMFC), despite being regarded as an ideal replacement to the internal combustion engine, is still not an economically attractive pri-mover due ...
David Price (18505), Hans Wahn (3478514), James Fish (3478511), Jean Bousquet (20909), Joaquin Sastre (808570), Kevin Murphy (678934), Leonardo Fabbri (651426), Malcolm Sears (3472010)   +7 more
core   +8 more sources