Results 81 to 90 of about 5,883,314 (302)

The influence of circadian variables on ecotoxicology metabolomics

Biological Reviews, EarlyView.
ABSTRACT Ecotoxicologists are using metabolomics increasingly to gain insight into toxicological mechanisms and sublethal effects of chemical exposures. Metabolomics offers a sensitive multi‐parameter approach that can detect biochemical responses not obvious using apical and behavioural endpoints.
Ryan I. Lester, David J. Beale, Anthony R. Carroll, Steven D. Melvin   +3 more
wiley   +1 more source

Sustained virologic response derived by genotype, cirrhosis status, HCV prior treatment, and treatment regimen, in intention-to-treat and modified intention-to-treat assessment (n = 527).

, 2018
Sustained virologic response derived by genotype, cirrhosis status, HCV prior treatment, and treatment regimen, in intention-to-treat and modified intention-to-treat assessment (n = 527).
Leticia Pisoni Zanaga (5497430), Marcelo Nardi Pedro (5497442), Maria Silvia Kroll Lazarini (5497445), Raquel Silveira Bello Stucchi (5497448), Fernando Lopes Goncales Jr (5497427), Aline Gonzalez Vigani (5497424), Noelle Miotto (5497433), Leandro Cesar Mendes (5497436), Eduardo Sellan Lopes Goncales (5497439)   +8 more
core   +1 more source

Pegylated Interferon and Ribavirin Dosing Strategies to Enhance Sustained Virologic Response [PDF]

Current Hepatitis Reports, 2010
Hepatitis C virus (HCV) affects about 170 million people worldwide and is the most common chronic blood borne infection in the United States. Since the advent of blood screening protocols in the early 1990s, injection drug use has become the leading cause of infection.
Chak, Eric, Saab, Sammy
openaire   +4 more sources

Biotic modulators of global change effects on plant communities

Biological Reviews, EarlyView.
ABSTRACT Understanding and predicting future plant biodiversity and productivity is critical for prioritizing global change mitigation, conservation, and restoration efforts. One major challenge is that we know remarkably little about how interspecific interactions may modulate the effects of global change factors on diversity and productivity.
Anu Eskelinen, Martin Andrzejak, W. Stanley Harpole, Susan Harrison, Aimée T. Classen, Anna‐Liisa Laine, Noémie A. Pichon, Anita C. Risch, Jake Alexander, Maria‐Theresa Jessen, Phoebe L. Zarnetske, Lotte Korell   +11 more
wiley   +1 more source

Prediction of sustained virologic responses to combination therapy of pegylated interferon-α and ribavirin in patients with chronic hepatitis C infection

Journal of Family and Community Medicine, 2013
Background and Aim: Hepatitis C virus (HCV) infection is a major health problem worldwide. Genotype-4 is the most common genotype in Saudi Arabia. The response to treatment with pegylated interferon-α combined with ribavirin in chronic HCV infection ...
Mona H Ismail
doaj   +1 more source

Sustained virologic response and relapse rates in treatment-naive Caucasian patients with HCV genotype 3 by baseline prediction score.

, 2016
A) Development cohort; B) Validation cohort SVR = sustained virologic response 24 weeks post-treatment. a 73 patients did not have a score and were omitted; of these, 46 (63.0%) achieved SVR.
Manuel Romero-Gomez (2262979), Tarik Asselah (717526), Alex J. Thompson (630738), Diethelm Messinger (3166401), Georgios Bakalos (2577070), Mitchell L. Shiffman (214538), Robert Flisiak (143093)   +6 more
core   +1 more source

Lipid droplet profiling during neutrophil differentiation by stimulated Raman scattering microscopy

Biotechnology Progress, EarlyView.
Abstract Lipid droplets (LDs) are dynamic organelles that serve as metabolic hubs and emerging regulators of immune cell fate. Although LDs have been implicated in immune regulation, how LD metabolism is remodeled during neutrophil differentiation and how stage‐specific LD dynamics shape mature neutrophil function remain poorly defined.
Ting‐Jung Sung, Bin Dong, Jingqiao Shen, Yan Tan, Chi Zhang, Xiaoping Bao   +5 more
wiley   +1 more source

Bone marrow‐like viscosity affects imatinib resistance in chronic myeloid leukemia

Biotechnology Progress, EarlyView.
Physical cues such as microenvironmental viscosity have been recognized as important regulators in controlling cell functions. However, even though the bone marrow (BM) is a viscous tissue in which cells respond mechanically to both the matrix stiffness and the viscosity of surrounding fluid, the impact of microenvironmental viscosity on imatinib (IM ...
Tianjiao Zeng, Huajian Chen, Man Wang, Toru Yoshitomi, Naoki Kawazoe, Yingnan Yang, Guoping Chen   +6 more
wiley   +1 more source

The sustained virologic response (SVR) 12 rate in the patients with co-existing NS5A and NS5B RASs.

, 2018
The interferon (IFN) free-naïve patients with coexisting resistance-associated substitutions (RASs) of Q24, L28, and/or R30, L31, or Y93 and NS5B A218 and/or C316 had a significantly lower sustained virologic response (SVR) 12 rate in comparison to the ...
Takeshi Kure (5328974), Tsutomu Tamai (496424), Kazuaki Tabu (496423), Kohei Oda (496422), Takeshi Hori (166759), Akihiro Moriuchi (496425), Masafumi Hashiguchi (5328965), Yukiko Inada (5328971), Kotaro Kumagai (496421), Hirofumi Uto (496418), Yasunari Hiramine (5328956), Seiichi Mawatari (496417), Kunio Fujisaki (5328962), Oki Taniyama (5328968), Sho Ijuin (5328953), Akio Ido (496419), Ai Kasai (5328959)   +16 more
core   +1 more source

Multiscale Modeling of an 8‐Week Combination Regimen of Bemnifosbuvir and Ruzasvir in Patients with Chronic Hepatitis C Virus Infection

Clinical Pharmacology &Therapeutics, EarlyView.
Bemnifosbuvir (BEM) and ruzasvir (RZR) are pan‐genotypic HCV polymerase (NS5B) and NS5A inhibitors, respectively. In a single‐arm study (NCT05904470), 215 treatment‐naïve, adherent participants with chronic HCV (with or without cirrhosis) received BEM 550 mg QD plus RZR 180 mg QD for 8 weeks.
Carolin Zitzmann, Ruy M. Ribeiro, Aurelien Marc, Xiao‐Jian Zhou, Alan S. Perelson   +4 more
wiley   +1 more source