Results 91 to 100 of about 5,883,314 (302)

Optimizing the Dose and Duration of Therapy for ChronicHepatitis C

Gut and Liver, 2009
Recent studies indicate that antiviral treatment with pegylated interferon alfa and ribavirin for hepatitis C can be individualized based on viral and host characteristics and the pattern of virologic response during the initial months of antiviral ...
doaj   +1 more source

Long‐Acting Therapeutics in Pediatric Health: Bridging Innovation and Access

Clinical Pharmacology &Therapeutics, EarlyView.
Children have distinct therapeutic needs arising from age‐dependent physiology, disease epidemiology, formulation requirements, dosing considerations, and safety vulnerabilities. Despite substantial reductions in childhood mortality over the past three decades, nearly 5 million children under five died in 2023, with infectious diseases continuing to ...
Prajith Venkatasubramanian, Moherndran Archary, Daniel B. Hawcutt, Rachel Daley, Edmund Capparelli, Adeniyi Olagunju   +5 more
wiley   +1 more source

Patient characteristics at hepatitis C virus (HCV) treatment start, treatment duration and sustained virologic response (SVR) according to HCV genotype group.

, 2015
Abbreviations: ART, antiretroviral therapy; HCV, hepatitis C virus; IDU, intravenous drug user; IQR, interquartile range; MSM, men who have sex with men; SVR, sustained viral response.Patient characteristics at hepatitis C virus (HCV) treatment start ...
Marcel Stöckle (776301), Margalida Rotger (252602), Enos Bernasconi (174329), Bruno Ledergerber (93996), Andri Rauch (76837), Andrea Bregenzer (776300), Matthias Cavassini (146654), Juan Ambrosioni (749142), Pablo Velli (776299), Roberto F. Speck (44947), Stefan Russmann (776298), Daniel Müller (243608), Helen Kovari (776297)   +12 more
core   +1 more source

Citizen Science Gamers Enable Automated Flow Cytometry Gating Through Machine Learning

Cytometry Part A, EarlyView.
ABSTRACT Machine learning can greatly accelerate biomedical research but is fundamentally constrained by the scarcity of high‐quality labeled data. We introduce a scalable data‐generation framework based on citizen science and apply it to automated flow cytometry gating, a foundational but subjective step in immunology that limits reproducibility ...
Sebastiano Montante, Daniel Yokosawa, Leon Li, Alexander Butyaev, Mehrnoush Malek, Razzi Movassaghi, Quentin Michalchuk, Chieh‐Ting Jimmy Hsu, David Shmil, Albina Rahim, Andrea Cossarizza, Julia Boira Esteban, Kornél Erhart, Bergur Finnbogason, George Kelion, Hjalti Leifsson, Josh Rivers, David Ecker, Attila Szantner, Jérôme Waldispühl, Ryan R. Brinkman   +20 more
wiley   +1 more source

Reframing Technology and Ethics in Corneal Xenotransplantation: A Scoping Review of Standards and Safety in Ophthalmology

Health Care Science, EarlyView.
Bringing attention to the moral dilemmas raised by xenotransplantation and the continuous creation of standardized frameworks for donor technology and biosafety risk management, with a focus on striking a balance between patient safety, medical innovation, and ethical obligation.
Sankhajyoti Saha, Moubani Dutta, Agnihiya Bosu   +2 more
wiley   +1 more source

Response-guided telaprevir combination treatment for hepatitis C virus infection. [PDF]

, 2011
Patients with chronic infection with hepatitis C virus (HCV) genotype 1 often need 48 weeks of peginterferon-ribavirin treatment for a sustained virologic response.
Flamm, Steven S.L., Reesink, Hendrik W, Christopher I. Wright, Fred Poordad, Adler, Michael, Sankoh, Abdul J, Wright, Christopher I., Poordad, Fred, Fried, Michael, Flamm, Steven L., Shelley George, ILLUMINATE Study Team, the, Sankoh, Abdul J., Flamm, Steven L, Wright, Christopher C.I., Sherman, Kenneth E, Everson, Gregory T, Nathalie Adda, Kauffman, Robert S., Nezam H. Afdhal, Martin, Marie, David R. Nelson, Sankoh, Abdul A.J., Sherman, Kenneth E., Michael W. Fried, Steven L. Flamm, Sherman, Kenneth K.E., Afdhal, Nezam H, Sulkowski, Mark, Robert S. Kauffman, Fried, Michael W, Kenneth E. Sherman, Van Vlierberghe, Hans, George, Shelley, Reesink, Hendrik W., Everson, Gregory G.T., Wright, Christopher I, Nelson, David, Kauffman, Robert S, Sulkowski, Mark S, Michael Adler, Marie Martin, Nelson, David R, Mark S. Sulkowski, Gregory T. Everson, Kauffman, Robert R.S., Nelson, David R., Abdul J. Sankoh, Afdhal, Nezam N.H., Adda, Nathalie, Afdhal, Nezam H., Hendrik W. Reesink, Reesink, Hendrik, Sulkowski, Mark S., Everson, Gregory T., Fried, Michael W.   +55 more
core   +1 more source

Clinicoepidemiologic Profile of Oral Kaposi Sarcoma in People Living With HIV: A Systematic Review and Meta‐Analysis

Head &Neck, EarlyView.
ABSTRACT Background To characterize the clinicoepidemiologic profile of HIV‐associated oral Kaposi sarcoma (OKS) and quantitatively synthesize its frequency, anatomical distribution, and temporal patterns across antiretroviral therapy (ART) eras. Methods Six databases and gray literature were searched.
Ericles Otávio, Rebeca Ferreira Badaró, Daniel Pignatari Mahet Rodrigues, Giselle de Medeiros Silva, José Alcides Almeida de Arruda, Victor Zanetti Drumond, Jefferson R. Tenório, Lucas Alves Jural, Marcela Baraúna Magno, Lucianne Cople Maia, Bruno Augusto Benevenuto de Andrade   +10 more
wiley   +1 more source

Management of Hepatitis C–Infected Patients After Sustained Virological Response [PDF]

Clinical Liver Disease, 2020
Watch an interview with the author Answer questions and earn CME.
openaire   +2 more sources

Characteristics of HIV-infected patients coinfected by HCV genotype 1 treated with pegylated interferon alpha 2a plus ribavirin (n = 187), grouped as a function of the presence or absence of rapid virological response.

, 2014
Abbreviations: SNP: Single nucleotide polymorphism. RVR: Rapid virologic response. ETR: Virologic response at the end of treatment. SVR: Sustained virologic response.
Almudena Torres-Cornejo (189653), Mercedes Márquez-Coello (596993), Antonio Rivero-Juárez (299565), Luis F. López-Cortés (189634), Antonio Rivero (189661), José-Antonio Girón-González (427101), Sara Corchado (427096)   +6 more
core   +1 more source

Mixed cryoglobulinemia decelerates hepatocellular carcinoma development in hepatitis C patients with SVR by downregulating regulatory B cells: a 12-year prospective cohort study

OncoImmunology
How mixed cryoglobulinemia (MC) affects cancer risk in chronic hepatitis C patients with sustained virologic response (SVR) remains unclear. In a 12-year prospective study, post-SVR MC was assessed every 3‒6 months. Among the 891 SVR patients, 265 (29.7%)
Ming-Ling Chang, Jur-Shan Cheng, Wei-Ting Chen, Yi-Jyun Shen, Chia-Jung Kuo, Rong-Nan Chien   +5 more
doaj   +1 more source