Results 61 to 70 of about 5,883,314 (302)

Does Hepatitis C Virus Treatment by Directly Acting Antivirals Obligate Shifting Patients with Type 2 Diabetes from Oral Hypoglycemic Drugs to Insulin Therapy?

Diabetes, Metabolic Syndrome and Obesity, 2022
Rasha Youssef Hagag,1,* Ahmed Fawzy Selim,1,* Omneya Mohamed Darrag,1 Hassan Zied,2 Mohamed Sabry Aboelnasr1 1Department of internal medicine, Faculty of medicine, Tanta University, Tanta, Egypt; 2Kafr-Elsheikh Liver Institute, Kafr-Elsheikh, Egypt*These
Hagag RY, Selim AF, Darrag OM, Zied H, Aboelnasr MS   +4 more
doaj  

Effectiveness of direct-acting antiviral drugs against hepatitis C virus: predictive factors of response to the treatment

Libyan Journal of Medicine, 2021
Background/Aims. Despite the high efficacy and safety of direct-acting antivirals against hepatitis C virus shown in clinical trials, treatment failures continue to occur.
María E. Cárdaba-García, Encarnación Abad-Lecha, Miguel Á. Calleja-Hernández   +2 more
doaj   +1 more source

Predictive factors associated with sustained virologic response in the cohort treated by Peg-IFN-based therapy.

, 2016
Predictive factors associated with sustained virologic response in the cohort treated by Peg-IFN-based therapy.
Caroline Besson (69818), Olivier Hermine (69824), Pascaline Rabiega (2817928), Danielle Canioni (69828), Delphine Bonnet (607285), Juliette Jeannel (3225042), Laurent Alric (336914), Stanislas Pol (254669), Nathanael Lapidus (343063), Frédéric Davi (697381), Patrice Cacoub (38095), Jean-Marie Michot (2817931), Loic Ysebaert (3225039)   +12 more
core   +1 more source

Sarbecoviruses Suppress Innate Immunity by Recruiting PPM1A to Modulate STAT2 and ORF9b Phosphorylation

Advanced Science, EarlyView.
Sarbecovirus ORF9b recruits host phosphatase PPM1A to suppress innate immunity through dual mechanisms. PPM1A directly dephosphorylates ORF9b to sustain its activity and indirectly downregulates STAT2 phosphorylation to impair interferon signaling. Pharmacological inhibition of PPM1A restores antiviral responses and limits sarbecovirus replication ...
Lixiang Xie, Ziye Huang, Zhiyuan Zhang, Yiqiang Zhu, Xiaoqing Liu, Lei Wang, Tongyu Bi, Taizhen Liang, Jintao Lai, Meilin Hu, Guochang Qiu, Shiqi Xiao, Sen Liu, Yaoming Liu, Haiyue Rao, Tao Chen, Haojie Peng, Bin Zhang, Jia Tang, Qianying Li, Yaxin Li, Yuxin Hou, Weibo Yang, Hewei Jiang, Xiancai Ma   +24 more
wiley   +1 more source

Modern pharmacotherapy of chronic hepatitis C in patients who failed to achieve sustained virologic response [PDF]

Annals of Mechnikov's Institute, 2020
Introduction. According to WHO experts, about 150 million people suffer from chronic viral hepatitis C (CHC), and 350,000 die annually as a result of liver damage by the hepatitis C virus (HCV).
Kireyev, I.V., Zhabotynska, N.V.
doaj   +1 more source

Treatment success results among AN/AI (sustained virologic response at 12 weeks post treatment) by intention-to-treat and per-protocol analyses with 95% confidence intervals [CI], Alaska, treated March 2014- December 2018.

, 2021
Treatment success results among AN/AI (sustained virologic response at 12 weeks post treatment) by intention-to-treat and per-protocol analyses with 95% confidence intervals [CI], Alaska, treated March 2014- December 2018.
Hannah G. F. Espera (11785803), John McGilvray (11785824), Annette M. Hewitt (11785809), Brenna C. Simons (11785827), Elena Roik (11785791), Julia N. Plotnik (11785818), James E. Gove (11785815), Mary M. Snowball (11785821), Janet M. Johnston (11785830), Chriss E. Homan (11785800), Dana J. T. Bruden (11785797), Youssef Barbour (11785794), Brian J. McMahon (11785833), Lisa Townshend-Bulson (222003), Timothy J. Stevenson (11785806), Wileina Rhodes (11785812)   +15 more
core   +1 more source

An Oral Antiviral Combination Against Severe COVID‐19 Enabled by the Synergistic Mechanisms of Action of Auranofin and Remdesivir

Advanced Science, EarlyView.
FDA‐approved anti‐inflammatory drug Auranofin inhibits SARS‐CoV‐2 replication by inhibiting viral Main protease activity and Spike processing required for viral entry. It shows strong synergy with nucleoside analogue Remdesivir, due to non‐overlapping mechanisms.
Oyahida Khatun, Rohan Narayan, Santhosh Kambaiah Nagaraj, Rishad Shiraz, Abinaya Kaliappan, Sumandeep Kaur, Ankur Singh, Siva Shanmugam Selvaraj, Gudepalya Renukaiah Rudramurthy, Chakenahalli Naveenkumar, Shridhar Narayanan, Radha Krishan Shandil, Shailly Tomar, Shashank Tripathi   +13 more
wiley   +1 more source

Haematological response of the patients from the B-NHL group treated by Peg-IFN-based therapy with or without sustained virologic response, * p = 0.02.

, 2016
Haematological response of the patients from the B-NHL group treated by Peg-IFN-based therapy with or without sustained virologic response, * p = 0.02.
Caroline Besson (69818), Olivier Hermine (69824), Pascaline Rabiega (2817928), Danielle Canioni (69828), Delphine Bonnet (607285), Juliette Jeannel (3225042), Laurent Alric (336914), Stanislas Pol (254669), Nathanael Lapidus (343063), Frédéric Davi (697381), Patrice Cacoub (38095), Jean-Marie Michot (2817931), Loic Ysebaert (3225039)   +12 more
core   +1 more source

Sustained virologic response to direct-acting antiviral agents predicts better outcomes in hepatitis C virus-infected patients: A retrospective study [PDF]

, 2019
Direct-acting antiviral agents (DAAs) are extremely effective in eradicating hepatitis C virus (HCV) in chronically infected patients. However, the protective role of the sustained virologic response (SVR) achieved by second- and third-generation DAAs ...
Sechi L. A., Soardo G., Catena, C., Brizzi, R. F., Catena C., Valenti, L., Colussi G., Brizzi R. F., Colussi, G., Cavarape A., Sechi, L. A., Valenti L., Donnini, D., Donnini D., Soardo, G., Maier, S., Cavarape, A., Maier S.   +17 more
core   +1 more source

Hot and cold deserts as eco‐evolutionary arenas for understanding plant resistance to multiple abiotic stressors

Biological Reviews, EarlyView.
ABSTRACT During their long evolutionary history, land plants have evolved a range of adaptations to different abiotic stressors. These help explain present‐day diversity and distribution patterns, as well as the potential resilience of natural and agricultural systems to a changing climate. Most previous research has focused on adaptation to individual
Marc Fradera‐Soler, Natasha Barbolini, Anže Žerdoner Čalasan, Marian Schubert, Catarina Rydin, Olwen M. Grace, Aelys M. Humphreys   +6 more
wiley   +1 more source