Results 61 to 70 of about 5,500,616 (251)

Sustained virologic response of the patients from the cohort treated by Peg-IFN-based therapy, * p< 0.02.

, 2016
First generation of protease inhibitors (PI1s). A: global sustained virologic response. B: sustained virologic response according to HCV genotype.
Caroline Besson (69818), Olivier Hermine (69824), Pascaline Rabiega (2817928), Danielle Canioni (69828), Delphine Bonnet (607285), Juliette Jeannel (3225042), Laurent Alric (336914), Stanislas Pol (254669), Nathanael Lapidus (343063), Frédéric Davi (697381), Patrice Cacoub (38095), Jean-Marie Michot (2817931), Loic Ysebaert (3225039)   +12 more
core   +1 more source

Programmable Nanobody‐Targeting Chimeras Enable Intracellular Viral Protein Degradation

Advanced Science, EarlyView.
Nab‐TAC enables targeted degradation of HBV surface antigen (HBsAg) in vivo. By fusing nanobody‐based recognition domains with programmable proteasome‐recruiting degradation signals, Nab‐TAC reduces HBsAg levels in a hydrodynamic HBV mouse model. ABSTRACT Chronic hepatitis B virus (HBV) infection remains a major global health challenge, largely because
Max Yu‐Chen Pan, Ting‐Hui Lee, Tzu‐Ning Peng, Eva Yi‐Hsuan Wu, Yu‐Ting Chiu, Chih‐Chien Chiu, Hong Vinh Nguyen, Yuan‐Shao Pao, Ming‐Hong Chao, Richard Kuan‐Lin Lee, Han‐Chung Wu, Lily Hui‐Ching Wang   +11 more
wiley   +1 more source

Modern pharmacotherapy of chronic hepatitis C in patients who failed to achieve sustained virologic response [PDF]

Annals of Mechnikov's Institute, 2020
Introduction. According to WHO experts, about 150 million people suffer from chronic viral hepatitis C (CHC), and 350,000 die annually as a result of liver damage by the hepatitis C virus (HCV).
Kireyev, I.V., Zhabotynska, N.V.
doaj   +1 more source

Collagen‐Binding IL‐15 Immunocytokine Armed Oncolytic Adenovirus Establishes a Self‐Reinforcing Immunostimulatory Milieu to Potentiate Antitumor Immunity

Advanced Science, EarlyView.
Repurposing the dense tumor stroma from a physical barrier into an anchoring scaffold, an engineered oncolytic adenovirus encoding IL15C‐CBD overcomes the immunosuppressive microenvironment in triple‐negative breast cancer. Intratumoral viral replication secretes this collagen‐anchored immunocytokine, forming a localized cytokine depot.
Yaqi Yang, Xiaoxiao Liu, Junqiang Ding, Jinliang Xu, Jianhua Zhang, Hanchang Zhang, Rong Yang, Sha Li, Lu Zheng, Runping Su, Yue Zhao, Jianxiao Wu, Hao Li, Changyou Zhan, Xihui Gao   +14 more
wiley   +1 more source

Platelet count and sustained virological response in hepatitis C treatment

World Journal of Hepatology, 2013
To examine the epidemiological data, hematological safety and treatment responses of peginterferon-alpha 2a plus ribavirin therapy for hepatitis C.Between March 2008 and February 2011, 196 hepatitis C virus (HCV) genotype 1 infected Japanese (127 treatment-naive and 69 treatment-experienced patients) patients treated with peginterferon-alpha 2a plus ...
Tatsuo, Kanda, Keizo, Kato, Akihito, Tsubota, Nobuo, Takada, Takayoshi, Nishino, Shigeru, Mikami, Tatsuo, Miyamura, Daisuke, Maruoka, Shuang, Wu, Shingo, Nakamoto, Makoto, Arai, Keiichi, Fujiwara, Fumio, Imazeki, Osamu, Yokosuka   +13 more
openaire   +2 more sources

Animal empathy reconsidered: a multidimensional profile account

Biological Reviews, EarlyView.
ABSTRACT Empathy is the glue that holds societies together and yet several fundamental questions about empathy persist. What is empathy (the definitional question)? Is it uniquely human and, if not, which nonhuman animals possess empathy (the distribution question)? Which type or quality of empathy is realized in different species (the quality question)
Albert Newen, Maja Griem, Ludwig Huber, Thomas Bugnyar, Aaron Blaisdell, Simone Pika   +5 more
wiley   +1 more source

How developmental stressors affect mitochondrial respiratory function: a systematic review and meta‐analysis

Biological Reviews, EarlyView.
ABSTRACT The environmental conditions organisms experience during early development can have powerful and sustained effects on morphology, physiology, behaviour, and performance. Such developmental effects can influence reproductive success, survival, and life‐history strategies and can be transmitted across generations (i.e.
Ondi L. Crino, Christopher R. Friesen, Geoffrey E. Hill, Dalton C. Leibold, Pablo Recio, Karine Salin, Kristoffer H. Wild, Daniel W.A. Noble   +7 more
wiley   +1 more source

Sofosbuvir/velpatasvir is an effective treatment for patients with hepatitis C and advanced fibrosis or cirrhosis in a real-world setting in Taiwan

BMC Gastroenterology, 2021
Introduction Real-world data regarding the impact of hepatic fibrosis on the effectiveness of sofosbuvir/velpatasvir (SOF/VEL) treatment is limited in the Asian population. Methods We analyzed data for all 823 patients with hepatitis C virus treated with
Yu-Ting Huang, Yung-Yu Hsieh, Wei-Ming Chen, Shui-Yi Tung, Kuo-Liang Wei, Chen-Heng Shen, Kao-Chi Chang, Chung-Kuang Lu, Chih-Wei Yen, Sheng-Nan Lu, Chao-Hung Hung, Te-Sheng Chang   +11 more
doaj   +1 more source

Pegylated Interferon and Ribavirin Dosing Strategies to Enhance Sustained Virologic Response [PDF]

Current Hepatitis Reports, 2010
Hepatitis C virus (HCV) affects about 170 million people worldwide and is the most common chronic blood borne infection in the United States. Since the advent of blood screening protocols in the early 1990s, injection drug use has become the leading cause of infection.
Chak, Eric, Saab, Sammy
openaire   +4 more sources

Heat stress in spermatogenesis: a redox‐dependent decision network linking ROS, autophagy, and regulated cell death

Biological Reviews, EarlyView.
ABSTRACT Heat stress (HS) is an increasing threat to male reproductive health, disrupting spermatogenesis through complex and interdependent cellular responses within the seminiferous epithelium. Although excessive reactive oxygen species (ROS) production is a hallmark of HS, ROS also act as central regulators of cell fate decisions beyond their role ...
Ribrio Ivan Tavares Pereira Batista
wiley   +1 more source