Results 141 to 150 of about 2,755 (265)

Harnessing Large‐Scale Multi‐Omics Data for Risk Prediction and Deep Phenotyping of Valvular Heart Diseases in the General Population

Advanced Science, EarlyView.
Large‐scale UK Biobank analyses identify clinical and proteomic signatures for early prediction of valvular heart disease and its subtypes. Proteins add predictive value for VHD, AVS, and MVR, with outcome‐specific compact panels showing translational potential. Multi‐layer evidence highlights matrix remodeling, protease regulation, immune inflammation,
Zhihao Jiang, Yang Liu, Mingyu Song, Ning Chen, Canqing Yu, Jun Lv, Eric Yuk Fai Wan, Lu Qi, Liming Li, Dianjianyi Sun, Bang Zheng   +10 more
wiley   +1 more source

Thromboxane signalling links immune activation to enhanced glucose uptake in skeletal muscle. [PDF]

Diabetologia
Abdelmoez AM, Jollet M, Yu X, Rizo-Roca D, Marica AA, Ortiz de Zevallos J, Dollet L, Borg ML, Björnholm M, Checa A, Olsson T, Otten J, Zierath JR, Krook A, Schwartz TW, Chibalin AV, Pillon NJ.   +16 more
europepmc   +1 more source

EphB1‐Mediated Transient Blood‐Brain Barrier Opening Facilitates a Ferritin‐Based Nanotherapeutic for Alzheimer's Disease

Advanced Science, EarlyView.
We constructed a brain‐targeted AFn‐DPZ nanodrug delivery system and identified EphB1 as its receptor on the blood‐brain barrier (BBB). This system facilitates drug transport across the BBB and thereby ameliorates cognitive impairment in Alzheimer's disease.
Shilin Wen, Jingjing Gao, Zhixian Wang, Qiumin Ma, Xiao‐Ling Xu, Jianer Chen   +5 more
wiley   +1 more source

Family planning, sexual activity and contraception in hereditary hemorrhagic telangiectasia: a European survey study. [PDF]

Orphanet J Rare Dis
Hessels J, Post MC, Boerman S, Droege F, Dupuis O, ePAG, Geisthoff UW, Haahr PD, Kjeldsen AD, Mager JJ, Dupuis-Girod S, Buscarini E.   +11 more
europepmc   +1 more source

Targeting GALNT7 Disrupts the TAZ O‐GalNAcylation Feedback Loop to Suppress Gallbladder Cancer Progression

Advanced Science, EarlyView.
Aberrant GALNT7‐mediated O‐GalNAcylation stabilizes TAZ to drive gallbladder cancer progression through a feed‐forward transcriptional loop. Structure‐based screening identifies Olaparib as a potent GALNT7 antagonist that disrupts this oncogenic axis, providing an immediate therapeutic strategy for this aggressive malignancy.
Peng Qiu, Ming Zhang, Yunxiang Feng, Yibo Deng, Kai Zhao, Xiangyu Li, Yun Lu, Li Tian, Tao Yang, Wei Yao, Jianming Wang, Zhengdong Deng   +11 more
wiley   +1 more source

Experiences of sleep problems, subsequent daytime consequences, and self-care activities used to improve sleep among patients with restless legs syndrome: a qualitative content analysis. [PDF]

J Res Nurs
Odzakovic E, Ingelsbo Petersson A, Lindholm Ericsson E, Öberg S, Jakobsson M, Björk M, Knutsson S, Fridlund B, Jonasson LL, Ulander M, Lind J, Broström A.   +11 more
europepmc   +1 more source

Real‐Time Investigation of Interfacial Evolution in Electrochemical Energy Storage Systems via EQCM

Advanced Science, EarlyView.
Understanding the electrode/electrolyte interface (EEI) is crucial for supercapacitors and batteries. EQCM, by enabling real‐time monitoring of mass changes during charge–discharge cycles, has evolved into a vital method for analysis of EEI. It provides important insights into charge‐storage mechanisms, electrode structural evolution, ion‐transfer ...
Zixuan Wang, Situo Cheng, Guang Feng
wiley   +1 more source

Sveriges miljömål

, 2011
Sveriges miljömål är viktiga för vår framtid. Riksdagen har antagit 16 mål för miljökvaliteten i Sverige. Målen beskriver den kvalitet och det tillstånd i miljön som är hållbara på lång sikt. Generationsmålet är det övergripande målet för miljöpolitiken. Det anger riktningen och bör vara vägledande för miljöarbetet på alla nivåer i samhället.
openaire   +1 more source

Red meat intake during pregnancy and childhood and risk of type 1 diabetes: findings from the ABIS birth cohort. [PDF]

Diabetologia
Lampousi AM, Zeng J, Löfvenborg JE, Carlsson S, Ludvigsson J.   +4 more
europepmc   +1 more source

Risk of Inflammatory Bowel Disease Following Hospital‐Treated Infections and Modulatory Role of Host Genetics to Support a Multi‐Hit Pathogenesis Model

Advanced Science, EarlyView.
Hospital‐treated infections are linked to increased risk of inflammatory bowel disease in a large prospective cohort. This risk differs by infection burden, time since infection, and host immune‐genetic susceptibility. The findings support a multi‐hit pathogenesis model in which severe infection and inherited susceptibility jointly shape inflammatory ...
Haiming Zhuang, Lintao Dan, Xin Xiang, Xixian Ruan, Shuai Yuan, Jialu Yao, Jiawei Geng, Jonas F. Ludvigsson, Tian Fu, Candida Abreu, Laurent Peyrin‐Biroulet, Xue Li, Yi Xiao, Fernando Magro, Xiaoyan Wang, Jing Sun, Jie Chen   +16 more
wiley   +1 more source