Results 101 to 110 of about 10,169 (345)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

LIME: Towards a Metadata Module for Ontolex [PDF]

, 2013
The OntoLex W3C Community Group has been working for more than a year on realizing a proposal for a standard ontol-ogy lexicon model. As the core-specification of the model is almost com-plete, the group started development of additional modules for ...
Fiorelli, M, Pazienza, M, Stellato, A
core   +2 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Development of Novel Canned Peaches (Fercluse Variety) as a Healthy and Possible Diabetic Food Choice

Applied Sciences
An upward trend has been observed in recent years in which consumers are actively more conscious about finding healthier food alternatives to purchase. Based on the constantly increasing demands of the diabetes food market, a new product of canned peach ...
Ioannis Prodromos Papachristoudis, Maria Dimopoulou, Smaro Kyroglou, Patroklos Vareltzis, Olga Gortzi   +4 more
doaj   +1 more source

A Novel Protocol for Stevia Rebaudiana (Bert.) Regeneration [PDF]

, 2013
Stevia rebaudiana Bertoni has sweet substances (stevioside) in its leaves that are free of calories and their consumption is beneficial for diabetic patients and is also helpful in high blood pressure also.
Ebrahimi, M. (Morteza), Mirniam, A. (Akram), Otroshi, M. (Mahmoud), Roshandel, P. (Parto)   +3 more
core   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Utilization of the ability to induce activation of the nuclear factor (erythroid-derived 2)-like factor 2 (Nrf2) to assess potential cancer chemopreventive activity of liquorice samples [PDF]

Introduction – Nuclear factor (erythroid-derived 2)-like factor 2 (Nrf2) is a transcription factor that regulates expression of many detoxification enzymes.
Akamatsu, Ameyar, Asha, Astafeva, Basar, Benzie, Bhullar, Bors, Chima, Copple, Dirican, Dong, Douglas, Duffy, Fazio, Fu, Hirabayashi, Hiroaki, Kalaiarasi, Kinoshita, Kou, Kumarasamy, Kwak, Lakshmi, Lee, Li, Li, Li, Li, Marianna, Marjan, Montoro, Okimasu, Petri, Rajandeep, Russo, Sara-Franceschelli, Scherer, Takao, Ullah, Vispute, Wang, Yang, Yu, Zadeh, Zhang, Zhang   +46 more
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Operational properties of catalysts for non-extractive oxidative demercaptanization of oil and petroleum fractions

Тонкие химические технологии, 2015
The results of identification of the main operational properties of metallocomplex catalysts solutions for non-extractive oxidative sweetening of natural hydrocarbons and their products are provided in this article. These catalysts allow carrying out the
Yu. A. Gavrilo, I. V. Pletneva, E. N. Silkina   +2 more
doaj