Results 61 to 70 of about 10,449 (207)

Penelusuran Senyawa Inhibitor Alpha-Glukosidase Potensial untuk Diabetes Melitus Tipe 2 melalui Pendekatan In Silico dengan Evaluasi Profil Adme Via SwissADME. [PDF]

The aim of this study was to demonstrate data retrieval from online databases to find compounds with relevant properties such as alpha-glucosidase inhibitors, which have the potential to be used in the treatment of Type 2 Diabetes Mellitus.
Nurfadilah
core   +2 more sources

Synthesis and in silico evaluation of some new 2,4-disubstituted thiazole derivatives [PDF]

, 2022
The synthesis and anti-proliferative activity investigation of methyl 3/4-[[4-(2-substituted thiazol-4-yl)phenyl]amino]-3-oxopropanoate/(4-oxobutanoate) (3a-h) derivatives were aimed in this work.

core   +1 more source

Pharmacological evaluation of Adenostemma lavenia acetone extract in Swiss Albino mice: Analgesic, anti‐inflammatory, and thrombolytic insights from in vivo, in vitro, density functional theory, and molecular docking studies

Animal Models and Experimental Medicine, EarlyView.
Adenostemma lavenia, a traditionally used medicinal plant, has been employed to manage pain, inflammation, and circulatory issues. This study investigates the analgesic, anti‐inflammatory, and thrombolytic potentials of the acetone extract of A. lavenia leaves (AEAL) using in vivo, in vitro, and in silico methods.
Nusrat Jahan Moon, Mahathir Mohammad, Md. Jahirul Islam Mamun, Fahmina Binty Azim Nova, Nazmul Hasan Eshaque, Md. Hossain Rasel, Zobayed Islam, Md. Mahmudul Hasan, Md. Liakot Ali, Md. Tanvir Chowdhury, S. M. Moazzem Hossen   +10 more
wiley   +1 more source

Application of the SwissDrugDesign Online Resources in Virtual Screening. [PDF]

, 2019
SwissDrugDesign is an important initiative led by the Molecular Modeling Group of the SIB Swiss Institute of Bioinformatics. This project provides a collection of freely available online tools for computer-aided drug design.
Daina, A., Zoete, V.
core   +1 more source

Pharmacological potential of 3-((indol-3-yl)methyl)-6-methyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine-7-carbohydrazide and its N′-arylidene carbohydrazides

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki
Rational design of novel biologically active compounds relies on the use of effective structural fragments capable of providing high bioaffinity, favorable pharmacokinetic properties, and an adequate safety profile.
S. O. Fedotov , A. S. Hotsulia
doaj   +1 more source

Urolithin A, a Diet‐Derived Gut Microbial Metabolite Against Pulmonary Hypertension Identified via Molecular Docking, Molecular Dynamics and Surface Plasmon Resonance

Food Safety and Health, EarlyView.
Urolithin A, a gut microbial metabolite, binds TNF to suppress proliferation, inflammation, and oxidative stress, offering a promising microbe‐derived therapeutic avenue for pulmonary hypertension. ABSTRACT Pulmonary hypertension (PH) is a complex and multifactorial disease that poses a significant clinical challenge.
Yujie Qu, Yinghua Huo, Yichen Wang, Yao Mu, Xue Yu, Leiyu Tian, Jian Guo, Xuezhi Yang, Yucai Chen   +8 more
wiley   +1 more source

Method Development And Validation Of Gliclazide For Different Pharmaceutical Formulation And Its Network Pharmacology Study [PDF]

, 2023
Purpose: The research outlined in this manuscript focuses on the critical aspects of method development and validation for Gliclazide, a pivotal antidiabetic medication with various pharmaceutical formulations.
Arvind Rathour, Brijesh Kumar, Nikhil Kumar, Vijay Kumar, Vivek Kumar Shisodia   +4 more
core   +2 more sources

Pharmacokinetics and Druglikeness of Amoxicillin Drug using SwissADME

Multicore International Journal of Multidisciplinary (MIJM)
Amoxicillin, a widely utilized semi-synthetic penicillin derivative, remains a cornerstone in treating various bacterial infections. Despite its extensive clinical application, a comprehensive in silico assessment of its pharmacokinetic and "druglikeness" properties using modern computational tools can provide valuable complementary insights.
Fendy Prasetyawan, Yuneka Saristiana, Ratna Mildawati, Eka Hayati Rhomah, Muhammad Nurul Fadel, Emma Jayanti Besan   +5 more
openaire   +1 more source

Synthesized flavone attenuates diabetes‐induced neurodegeneration through regulation of oxidative stress and metabolic‐neurodegenerative molecular pathways

Ibrain, EarlyView.
Neuroprotective efficacy of flavone (2‐phenyl‐4H‐chromen‐4‐one). The study aimed to explore the potential of a synthetic derivative (flavone) of a phytocompound, which is involved in neuroprotection activities. Experimental strategies included the characteristics of compound, in‐silico analysis, and in vivo assessments.
Karishma Sen, Anita Sakarwal, Heera Ram, Suman K. Saha, Nirmal K. Rana, Dharmveer Yadav, Sunil Dutt Shukla, Mukesh Kumar Yadav, Balachandar Vellingiri, Vikas Kumar   +9 more
wiley   +1 more source

Prediction of the anti-inflammatory effects of bioactive components of a Hippocampus species-based TCM formulation on chronic kidney disease using network pharmacology [PDF]

, 2021
Purpose: To systematically study and predict the therapeutic targets and signaling pathways of Hippocampus (HPC) against chronic kidney disease (CKD) using network pharmacology.Methods: By combining database mining, literature searching, screening of ...
Hu, Zhang, Kong, Songzhi, Li, Chengpeng, Liao, Mingneng, Lu, Sitong, Zhang, Lingyu   +5 more
core   +2 more sources