Results 51 to 60 of about 10,523 (171)
Food Chemistry International, EarlyView.The graphical abstract represents how natural plant products that preferentially target the specific receptors of quorum sensing could be developed to combat biofilms linked to Yersinia enterocolitica using the potent abilities of protein–ligand complexes with high docking scores.
Rajendran Thomas +7 more
wiley +1 more source
Penelusuran Senyawa Inhibitor Dipeptidyl Peptidase-4 (DPP-4 Inhibitors atau Gliptin) Potensial untuk Diabetes Melitus Tipe 2 melalui Pendekatan In Silico dengan Evaluasi Profil ADME via SwissADME [PDF]
This study aims to identify the potential of in silico methods as a rapid and cost-effective approach for the initial screening of DPP-4 inhibitor candidates, as well as to identify compounds that meet drug-likeness criteria and exhibit good ADME ...
Apriyani Pramudiyawati Yunar
core +1 more source
Journal of Applied Toxicology, EarlyView.ABSTRACT In this study, ten novel compounds (IPH1–IPH10) were designed by integrating three pharmacophores (isatin, piperazine, and hydrazone) commonly found in the molecular structures of anticancer agents. The target molecules were obtained by the reaction of in‐house prepared 4‐(4‐(pyridin/pyrimidin‐2‐yl)piperazin‐1‐yl)benzohydrazide with various ...
Semiha Köprü +3 more
wiley +1 more source
Pest Management Science, EarlyView.Phenoxazinones caused differential types of phytotoxic effects in C. campestris early development. APO is a coherent lead inhibiting C. campestris germination and early seedling growth. Abstract BACKGROUND 2‐Amino‐3H‐phenoxazin‐3‐one (synonym: questiomycin A; abbreviated as APO or Phx‐3) is a naturally occurring phenoxazinone‐type allelochemical with ...
Cristina Díaz‐Franco +5 more
wiley +1 more source
Phytotherapy Research, EarlyView.ABSTRACT Obesity is a major risk factor for type 2 diabetes. Some traditional Chinese medicine (TCM) compounds can improve obesity by increasing energy consumption. This study aimed to identify and verify TCM compounds that promote adipose thermogenesis to alleviate obesity via transcriptomic analysis, molecular docking, network pharmacology, and ...
Jing Li +6 more
wiley +1 more source
Phytotherapy Research, EarlyView.Salvia miltiorrhiza Bunge in metabolic syndrome and cardiovascular diseases: multi‐target actions on shared signaling pathways. ABSTRACT Metabolic syndrome (MetS) represents a clinical disorder characterized by the clustering of conditions including obesity, elevated blood sugar levels, and high lipid levels, which are intricately linked to the onset ...
Zhiyi Jia +6 more
wiley +1 more source
Synthesis, in-vitro inhibition of cyclooxygenases and in silico studies of new isoxazole derivatives
Frontiers in Chemistry, 2023 Isoxazole belongs to the class of five-membered heterocyclic compounds. The process of developing new drugs has significantly gained attention due to inadequate pharmacokinetic and safety attributes of the available drugs.
Waqas Alam +6 more
doaj +1 more source
Phytotherapy Research, EarlyView.Dihydroartemisinin Engages NQO1 and Promotes Ferroptosis‐Related Oxidative Stress in Non‐Small Cell Lung Cancer. ABSTRACT Dihydroartemisinin (DHA), a bioactive derivative of Artemisia annua L. (AAL), has shown antitumor activity in several malignancies, including non‐small cell lung cancer (NSCLC).
Xiuli Guo +11 more
wiley +1 more source
Schematic representation of physicochemical properties and SARs for trypanocidal activity.
, 2020 EC50 calculated for amastigote forms of T. cruzi (Tuhaluen strain). CC50 calculated for the LLCMK2 strain (host cell). Green areas highlight biochemical results. TPSA, ilogP, and Ali_Logs have been calculated with the swissADME online service [35].
Fabiana Rosini (769679) +14 more
core +1 more source
The FEBS Journal, EarlyView.Cystathionine‐β‐synthase (CBS) helps remove harmful homocysteine and supports the production of protective sulfur‐containing molecules. Using its natural activator, S‐adenosyl‐l‐methionine, as a template, we designed and tested 15 analogues. Three activated and stabilized the enzyme, including the newly identified S‐2‐amino‐adenosyl‐l‐methionine. These
Dalibor Nakládal +18 more
wiley +1 more source