Results 31 to 40 of about 10,449 (207)

Metabolite profile of Nectandra oppositifolia Nees & Mart. and assessment of antitrypanosomal activity of bioactive compounds through efficiency analyses [PDF]

, 2021
EtOH extracts from the leaves and twigs of Nectandra oppositifolia Nees & Mart. shown activity against amastigote forms of Trypanosoma cruzi. These extracts were subjected to successive liquid-liquid partitioning to afford bioactive CH2Cl2 fractions ...
Alves Conserva, Geanne A., Costa-Silva, Thais A., Fernandes, João Paulo S., Lago, João Henrique G., Marcourt, Laurence, Pinto, Erika G., Queiroz, Emerson F., Quirós-Guerrero, Luis M., Tempone, Andre G., Wolfender, Jean-Luc   +9 more
core   +2 more sources

In Silico Study to Predict the Potential of Beta Asarone, Methyl Piperonylketone, Coumaric Acid in Piper Crocatum as Anticancer Agents

Journal of Experimental Life Science, 2021
Piper Crocatum Ruiz & Pav leaves often be used to treat various diseases, including cancer, empirically. This study aimed to analyze the anticancer activities of Piper Crocatum bioactive compounds via In Silico analysis.
Ahmed Hasan Abkar, Moch. Sasmito Djati, Widodo Widodo   +2 more
doaj   +1 more source

Прогнозування фізико-хімічних властивостей 2-оксадіазолонзаміщених бензойних кислот та їхніх аналогів як потенційних лікарських засобів методом SwissADME

Bulletin of Taras Shevchenko National University of Kyiv. Chemistry, 2023
Background . Heterocyclic compounds have a high value for the pharmaceutical industry due to their numerous presence in the structural components of the active substances of drugs. In particular, they have an antihypertensive effect. Azilsartan, which contains a heterocyclic oxadiazolone fragment, is a representative of such drugs.
Olga HORDIYENKO, Anastasiya SKARULIS, Volodymyr TKACHUK   +2 more
openaire   +2 more sources

β-Aminopropioamidoximes derivatives as potential antitubercular agents against anthropozoonotic infections caused by Mycobacterium tuberculosis and Mycobacterium bovis [PDF]

Veterinary World
Background and Aim: Tuberculosis (TB) remains a significant global health challenge, with increasing incidences of drug-sensitive (DS) and multidrug-resistant (MDR) TB.
Lyudmila Kayukova, Venera Bismilda, Kairat Turgenbayev, Asem Uzakova, Gulnur Baitursynova, Umirzak Jussipbekov, Meruyert Mukanova, Lyailya Chingissova, Gulnur Dyussembayeva, Assiya Borsynbayeva, Azamat Yerlanuly, Ablay Auyezov   +11 more
doaj   +1 more source

Quantitative structure-activity relationship, molecular docking, drug-likeness, and pharmacokinetic studies of some non-small cell lung cancer therapeutic agents

Beni-Suef University Journal of Basic and Applied Sciences, 2020
Background Lung cancer has been reported to be among the leading cancer cases in the world. It was also reported to have caused a lot of death every year and accounted for about one-third of the whole cancer deaths in the globe.
Muhammad Tukur Ibrahim, Adamu Uzairu, Sani Uba, Gideon Adamu Shallangwa   +3 more
doaj   +1 more source

Potential application of bisoprolol derivative compounds as antihypertensive drugs: synthesis and in silico study

Royal Society Open Science, 2023
Two bisoprolol derivatives, N-acetyl bisoprolol and N-formyl bisoprolol, belonging to the beta-blocker class of antihypertensive drugs, were synthesized using acetylation and formylation reactions. The yields of the reactions were determined to be 32.40%
Ni Putu Sani Oktaviani, Atthar Luqman Ivansyah, Muhammad Yogi Saputra, Nurrahmi Handayani, Nurdiani Fadylla, Deana Wahyuningrum   +5 more
doaj   +1 more source

QSAR MODELING OF pKа VALUES OF SULFONYLUREA HERBICIDES [PDF]

, 2023
Sulfonylureas are herbicides primarily used for control of weeds in early growth stages of cultivations. Structurally sulfonylureas contain a sulfonyl group with sulphur atom bonded to nitrogen atom of an ureylene group.
Dimitrovski, Dejan, Dimova, Vesna, Jordanov, Igor, Krstevska, Kristina   +3 more
core   +1 more source

Structural characterization of TRAF6 N-terminal for therapeutic uses and computational studies on new derivatives [PDF]

, 2023
: Tumor necrosis factor receptor-associated factors (TRAFs) are a protein family with a wide variety of roles and binding partners. Among them, TRAF6, a ubiquitin ligase, possesses unique receptor binding specificity and shows diverse functions in immune
Abdulilah Ece, Belgin Sever, Faika Başoğlu-Ünal, Halilibrahim Ciftci, Hasan DeMirci, Hiroshi Tateishi, Jun-ichiro Inoue, Masami Otsuka, Mikako Fujita, Mohamed O. Radwan, Mustafa Can, Mutlu Dilsiz Aytemir, Nefise Demir, Omur Guven, Ryoko Koga   +14 more
core   +1 more source

Hierarchical Virtual Screening of Potential New Antibiotics from Polyoxygenated Dibenzofurans against Staphylococcus aureus Strains [PDF]

, 2023
Supplementary Materials: The following supporting information can be downloaded at: https: //www.mdpi.com/article/10.3390/ph16101430/s1, Table S1.
Campos Rosa, Joaquín María, Oliveira, Lana P. S.   +1 more
core   +1 more source

Solubility and ADMET profiles of short oligomers of lactic acid [PDF]

, 2020
Polylactic acid (PLA) is a polymer with an increased potential to be used in different medical applications, including tissue engineering and drug-carries.
Adriana Isvoran, Alecu Aurel Ciorsac, Daniela Dascălu, Diana Larisa Roman, Madalina Filip, Vasile Ostafe   +5 more
core   +2 more sources