Results 41 to 50 of about 10,449 (207)

Evaluasi Parameter Fisikokimia, Farmakokinetika, dan Farmakodinamika Senyawa Fisetin Dalam Desain Obat [PDF]

open access: yes, 2022
Fisetin is a flavonoid with flavonol framework found in various fruits and vegetables such as strawberries, apples, persimmons, lotus root, grapes, onions, kiwi, peaches, and others.
Fadlan, Arif   +2 more
core   +2 more sources

Cuminaldehyde potentiates the antimicrobial actions of ciprofloxacin against Staphylococcus aureus and Escherichia coli.

open access: yesPLoS ONE, 2020
Escherichia coli and Staphylococcus aureus are important agents of urinary tract infections that can often evolve to severe infections. The rise of antibiotic-resistant strains has driven the search for novel therapies to replace the use or act as ...
Valério Monteiro-Neto   +16 more
doaj   +1 more source

Application of QSAR Method in the Design of Enhanced Antimalarial Derivatives of Azetidine-2-carbonitriles, their Molecular Docking, Drug-likeness, and SwissADME Properties.

open access: yesIranian journal of pharmaceutical research : IJPR, 2021
The resistance of the P. falciparum strain to some of the antimalarial drugs has been a dominant dilemma facing the treatment of this fetid disease. This necessitates the detection and development of new antimalarial agents targeting the P. falciparum.
Ibrahim, Zakari Ya&#;u   +3 more
openaire   +2 more sources

Stimulatory Effects of Lycium shawii on Human Melanocyte Proliferation, Migration, and Melanogenesis: In Vitro and In Silico Studies [PDF]

open access: yes, 2023
There is no first-line treatment for vitiligo, a skin disease characterized by a lack of melanin produced by the melanocytes, resulting in an urgent demand for new therapeutic drugs capable of stimulating melanocyte functions, including melanogenesis. In
Al-Eidi, Hamad   +10 more
core   +2 more sources

Fragment-Based Drug Discovery of SARS-CoV-2 Therapeutics [PDF]

open access: yes, 2021
During the COVID-19 pandemic, the usual drug development timeline has been substantially condensed. This shortened timeline aims to allow for a safe and effective therapy to be discovered as soon as possible as the number of global COVID cases rise ...
Johnson, Hannah, \u2722
core   +1 more source

Development and optimization of solid lipid nanoparticles loaded with Glimepiride for enhancement of pharmacokinetic and therapeutic applicability [PDF]

open access: yes, 2023
Diabetes mellitus, particularly type 2 diabetes, is a growing global health concern. Glimepiride, a widely used antidiabetic drug, faces challenges related to its poor aqueous solubility and short half-life, impacting its pharmacokinetics and therapeutic
Brijesh Kumar, Nikhil Kumar, Vivek Kumar Sisodia, Arvind Rathour, Vijay Kumar
core   +2 more sources

DNA Damage prevention by the use of Computational Designed Microlpastics adsorbing Chemicals.

open access: yesBaghdad Journal of Biochemistry and Applied Biological Sciences
Cancer development is driven by uncontrolled cellular proliferation resulting from the accumulation of genetic mutations. One of the most well-studied mechanisms behind these mutations is DNA damage.
Khadija Abbas Sahan, Zahraa Abbas Sahan
doaj   +1 more source

In silico prediction of the pharmacological potential of new 7-alkyl-8-hydrazine derivatives of 1,3-dimethylxanthine

open access: yesAktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki
The development of new drug-like molecules based on 7-R-8-hydrazine derivatives of 1,3-dimethylxanthine is promising in view of the known pharmacological effect of theophylline and functional hydrazine derivatives.
L. M. Mosula   +2 more
doaj   +1 more source

The drug likeness analysis of anti-inflammatory clerodane diterpenoids

open access: yesChinese Medicine, 2020
Inflammation is an active defense response of the body against external stimuli. Long term low-grade inflammation has been considered as a deteriorated factor for aging, cancer, neurodegeneration and metabolic disorders.
Zheling Feng   +3 more
doaj   +1 more source

In silico identification of potential natural product inhibitors of human proteases key to SARS-CoV-2 infection

open access: yes, 2020
Presently, there are no approved drugs or vaccines to treat COVID-19 which has spread to over 200 countries and is responsible for over 3,65,000 deaths worldwide.
Biswal, Himansu S.   +4 more
core   +1 more source

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