Results 41 to 50 of about 10,523 (171)

Evaluation in silico du profil toxicologique de quelques molécules isolées de Aloe vera et de la pastèque (Citrullus lanatus) utilisées dans la formulation des crèmes solaires

Revue Congolaise des Sciences et Technologies
La pharmacocinétique et la toxicologie cutanées sont importantes en cosmétologie, car les effets nocifs de la lumière ultraviolette nécessitent une photoprotection externe, comme les crèmes solaires contenant des filtres solaires.
Christian V. Mulombela, Mardochée M. Kadima, Kelly T. Mwanda, Mbanga Lokebo, Hilaire V.S. Mambo, Pierre O. Lohohola, Damien S.T. Tshibangu, Koto-Te-Nyiwa Ngbolua, Sylvie-Mireille N. Bambi, Pius T. Mpiana, Virima Mudogo, Aristote Matondo   +11 more
doaj   +1 more source

The drug likeness analysis of anti-inflammatory clerodane diterpenoids

Chinese Medicine, 2020
Inflammation is an active defense response of the body against external stimuli. Long term low-grade inflammation has been considered as a deteriorated factor for aging, cancer, neurodegeneration and metabolic disorders.
Zheling Feng, Jun Cao, Qingwen Zhang, Ligen Lin   +3 more
doaj   +1 more source

The MoSR‐MoDde1 Regulatory Axis: A Novel Determinant of DMI Sensitivity and a Target for Sustainable Rice Blast Control

Advanced Science, EarlyView.
The transcription factor MoSR governs DMI fungicide sensitivity in Magnaporthe oryzae through dual regulation of ergosterol biosynthesis and the detoxification enzyme MoDde1. Targeting MoDde1 via a small‐molecule inhibitor or host‐induced gene silencing enhances DMI efficacy against rice blast, offering a sustainable disease management strategy ...
Fan‐Zhu Meng, Wen‐Kai Wei, Meng‐Yao Wu, Min‐Zheng Cai, Yu‐Fu Wang, Li Zhao, Shuai Meng, Liang‐Fen Yin, Guido Schnabel, Wei‐Xiao Yin, Chao‐Xi Luo   +10 more
wiley   +1 more source

Virtual screening benzimidazole derivatives with the highest bioavailability [PDF]

, 2023
The purpose of the study was to identify benzimidazole derivatives with high oral bioavailability using SwissADME web-tool.Цель исследования - поиск биологически активных соединений среди производных бензимидазола с максимальной пероральной ...
Goryunova, L. V., Придворов, Г. В., Горюнова, Л. В., Mukha, O. Y., Муха, О. Ю., Pridvorov, G. V.   +5 more
core  

Exploring Public Health Benefits of Dolichos Lablab as A Dietary Supplement During The COVID-19 Outbreak: A Computational Study [PDF]

, 2020
The emerging case of coronavirus disease-19 (COVID-19) caused by the severe acute respiratory syndrome-coronavirus (SARS-CoV-2) virus has become a global health issue.
Elly Purwanti, -, Hermanto Feri Eko, Purwanti, Elly, Souhaly Jantje Wiliem, Prihanta Wahyu, Prihanta, Wahyu, Indria Permana, Tutut, Purwanti Elly, Wiliem Souhaly, Jantje, Eko Hermanto, Feri, Permana Tutut Indria   +10 more
core   +5 more sources

Baihe Zhimu Decoction ameliorates anxious depression via PI3K/AKT/mTOR pathway‐mediated neuroprotection and inhibition of hippocampal neuronal apoptosis

Animal Models and Experimental Medicine, EarlyView.
Baihe Zhimu Decoction alleviates anxious depression‐like behaviors and protects hippocampal neurons. Chemical profiling and network pharmacology reveal multiple active components acting via the PI3K/AKT/mTOR pathway, enhancing neuronal survival and function, as confirmed by multi‐level in vitro and in vivo validation.
Yuanshan Han, Kexin He, Haolan Yang, Jiacheng Dai, Ronglin Chen, Yang Liu, Yuhong Wang, Lin Tang, Hongqing Zhao   +8 more
wiley   +1 more source

Identification of Potential New Aedes aegypti Juvenile Hormone Inhibitors from N-Acyl Piperidine Derivatives: A Bioinformatics Approach [PDF]

, 2022
Aedes aegypti mosquitoes transmit several human pathogens that cause millions of deaths worldwide, mainly in Latin America. The indiscriminate use of insecticides has resulted in the development of species resistance to some such compounds. Piperidine, a
Lima, Lúcio R., Espejo Román, José Manuel, Edla L. V. S. Dos Santos, Bastos, Ruan S., Santos, Cleydson B. R., Samuel S. da R. Pita, Ruan S. Bastos, Leão, Rozires P., Humberto F. De Freitas, Williams J. C. Macêdo, Lúcio R. Lima, Elenilze F. B. Ferreira, De Freitas, Humberto F., José M. Espejo-Román, Dos Santos, Edla L. V. S., Espejo-Román, José M., Ferreira, Elenilze F. B., Cleydson B. R. Santos, Pedro H. F. Araújo, Ryan da S. Ramos, Pita, Samuel S. da R., Ramos, Ryan da S., Rozires P. Leão, Macêdo, Williams J. C., Araújo, Pedro H. F.   +24 more
core   +1 more source

Click Bioconjugation of Aza‐BODIPY Fluorophores to LfcinB Peptides for Improved Biocompatibility

European Journal of Organic Chemistry, EarlyView.
Click bioconjugation attaches NIR aza‐BODIPY fluorophores to LfcinB‐derived anticancer peptides via CuAAC and thiol‐maleimide chemistry. Conjugates exhibit improved predicted solubility while retaining strong NIR absorption (703–730 nm). Peptide‐aza‐BODIPY conjugates induce apoptotic morphology in HeLa cancer cells.
A. Verónica Rodríguez‐Mayor, Maricela Morales, Héctor Manuel Pineda‐Castañeda, Zuly Jenny Rivera‐Monroy, Javier Eduardo García‐Castañeda, Norberto Farfán, Rosa Santillan   +6 more
wiley   +1 more source

Penelusuran Senyawa Inhibitor Alpha-Glukosidase Potensial untuk Diabetes Melitus Tipe 2 melalui Pendekatan In Silico dengan Evaluasi Profil Adme Via SwissADME. [PDF]

The aim of this study was to demonstrate data retrieval from online databases to find compounds with relevant properties such as alpha-glucosidase inhibitors, which have the potential to be used in the treatment of Type 2 Diabetes Mellitus.
Nurfadilah
core   +1 more source

Pharmacological potential of 3-((indol-3-yl)methyl)-6-methyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine-7-carbohydrazide and its N′-arylidene carbohydrazides

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki
Rational design of novel biologically active compounds relies on the use of effective structural fragments capable of providing high bioaffinity, favorable pharmacokinetic properties, and an adequate safety profile.
S. O. Fedotov , A. S. Hotsulia
doaj   +1 more source