Results 11 to 20 of about 586,333 (267)

The Dynamic Transition of Persistence toward the Viable but Nonculturable State during Stationary Phase Is Driven by Protein Aggregation

mBio, 2021
Decades of research into bacterial persistence has been unable to fully characterize this antibiotic-tolerant phenotype, thereby hampering the development of therapies effective against chronic infections.
Liselot Dewachter, Celien Bollen, Dorien Wilmaerts, Elen Louwagie, Pauline Herpels, Paul Matthay, Ladan Khodaparast, Laleh Khodaparast, Frederic Rousseau, Joost Schymkowitz, Jan Michiels   +10 more
doaj   +1 more source

Structural hot spots for the solubility of globular proteins

Nature Communications, 2016
Mutations in aggregation prone regions of recombinant proteins often improve their solubility, although they might cause negative effects on their structure and function.
Ashok Ganesan, Aleksandra Siekierska, Jacinte Beerten, Marijke Brams, Joost Van Durme, Greet De Baets, Rob Van der Kant, Rodrigo Gallardo, Meine Ramakers, Tobias Langenberg, Hannah Wilkinson, Frederik De Smet, Chris Ulens, Frederic Rousseau, Joost Schymkowitz   +14 more
doaj   +1 more source

“Switched”: store‐switching behaviours [PDF]

International Journal of Retail & Distribution Management, 2008
PurposeThe purpose of this paper is to investigate store‐switching behaviours for main food‐shopping consequent on a change in operator for a major superstore; to relate results to previous research findings on store‐switching levels; and to use the results to emphasise new directions and dimensions for store‐switching research.Design/methodology ...
Findlay, Anne, Sparks, Leigh
openaire   +2 more sources

Sleeping at the switch [PDF]

eLife, 2021
Sleep slow waves are studied for their role in brain plasticity, homeostatic regulation, and their changes during aging. Here, we address the possibility that two types of slow waves co-exist in humans. Thirty young and 29 older adults underwent a night of polysomnographic recordings.
Maude Bouchard, Jean-Marc Lina, Pierre-Olivier Gaudreault, Alexandre Lafrenière, Jonathan Dubé, Nadia Gosselin, Julie Carrier   +6 more
openaire   +3 more sources

ScienceBox 2.0: Evolving the demonstrator package for CERN storage and analysis services [PDF]

EPJ Web of Conferences
With containers being the de-facto standard to package, distribute, and run applications, Helm charts are on the rise for application deployment in managed clusters (e.g., Kubernetes, OpenShift), providing developers and operators with a rich ecosystem ...
Bocchi Enrico, Desai Jimil, Alfageme Sainz Samuel   +2 more
doaj   +1 more source

Optical Interconnection for Datacenters: To Switch or Not to Switch

2023 23rd International Conference on Transparent Optical Networks (ICTON), 2023
The research leading to these results has received funding from the Spanish AEI IBON (PID2020-114135RBI00) project and the Generalitat de Catalunya AGAUR (2021 SGR-00598).
Comellas Colomé, Jaume, Junyent Giralt, Gabriel   +1 more
openaire   +2 more sources

Aggregating sequences that occur in many proteins constitute weak spots of bacterial proteostasis

Nature Communications, 2018
Aggregation is sequence-specific and nucleated by short aggregating protein segments (APR). Here authors use a multidisciplinary approach to show that in E.coli some frequently occurring APRs lead to protein aggregation and ultimately bacterial cell ...
Ladan Khodaparast, Laleh Khodaparast, Rodrigo Gallardo, Nikolaos N. Louros, Emiel Michiels, Reshmi Ramakrishnan, Meine Ramakers, Filip Claes, Lydia Young, Mohammad Shahrooei, Hannah Wilkinson, Matyas Desager, Wubishet Mengistu Tadesse, K. Peter R. Nilsson, Per Hammarström, Abram Aertsen, Sebastien Carpentier, Johan Van Eldere, Frederic Rousseau, Joost Schymkowitz   +19 more
doaj   +1 more source

Low-Voltage and High-Reliability RF MEMS Switch with Combined Electrothermal and Electrostatic Actuation

Micromachines, 2021
In this paper, we report a novel laterally actuated Radio Frequency (RF) Microelectromechanical Systems (MEMS) switch, which is based on a combination of electrothermal actuation and electrostatic latching hold.
Yong Zhu, Jitendra Pal
doaj   +1 more source

Switching to learn

2015 American Control Conference (ACC), 2015
A network of agents attempt to learn some unknown state of the world drawn by nature from a finite set. Agents observe private signals conditioned on the true state, and form beliefs about the unknown state accordingly. Each agent may face an identification problem in the sense that she cannot distinguish the truth in isolation.
Shahin Shahrampour, Mohammad Amin Rahimian, Ali Jadbabaie   +2 more
openaire   +2 more sources

Next-Gen Storage Infrastructure for ALICE [PDF]

EPJ Web of Conferences
ALICE introduced ground-breaking advances in data processing and storage requirements and presented the CERN IT data center with new challenges with the highest data recording requirement of all experiments.
Peters Andreas Joachim, Sindrilaru Elvin Alin, Betev Latchezar, Contescu Cristian, Del Monte Gianmaria, Ducret Vincent, Grigoras Costin, Lamanna Massimo, Mascetti Luca, Panzer-Steindel Bernd, Pomponi Daniele   +10 more
doaj   +1 more source