Results 11 to 20 of about 1,943,775 (315)

Reversible ON- and OFF-switch chimeric antigen receptors controlled by lenalidomide

Science Translational Medicine, 2021
Two chemical genetic control systems were engineered to regulate CAR T cell function with lenalidomide. Flipping the switch on T cells Cell-based treatments such as chimeric antigen receptor (CAR) T cells have been finding increasing applications against
Max Jan, Irene Scarfò, R. Larson, Amanda J. Walker, A. Schmidts, A. Guirguis, Jessica A. Gasser, Mikołaj Słabicki, Amanda A Bouffard, A. Castano, M. Kann, Maria L. Cabral, Alexander Tepper, Daniel E. Grinshpun, A. Sperling, Taeyoon Kyung, Quinlan L. Sievers, M. Birnbaum, M. Maus, B. Ebert   +19 more
semanticscholar   +1 more source

Targeting S100B with Peptides Encoding Intrinsic Aggregation-Prone Sequence Segments

Molecules, 2021
S100 proteins assume a diversity of oligomeric states including large order self-assemblies, with an impact on protein structure and function. Previous work has uncovered that S100 proteins, including S100B, are prone to undergo β-aggregation under ...
Joana S. Cristóvão, Mariana A. Romão, Rodrigo Gallardo, Joost Schymkowitz, Frederic Rousseau, Cláudio M. Gomes   +5 more
doaj   +1 more source

Sectionalizing Switches Placement in Distribution Networks Using BTLBO [PDF]

International Journal of Research and Technology in Electrical Industry, 2023
Sectionalizing switches (SS) and lines play an essential role in improving the performance of the distribution automation system as well as reducing the outage duration of power grid customers. The operation of the sectionalizing switches and whether the
Saeed Fayyazi, Ehsan Azad Farsani
doaj   +1 more source

SWITCHING GRAPHS

International Journal of Foundations of Computer Science, 2008
Switching graphs are graphs that contain switches. A switch is a pair of edges that start in the same vertex and of which precisely one edge is enabled at any time. By using a Boolean function called a switch setting, the switches in a switching graph can be put in a fixed direction to obtain an ordinary graph.
Groote, J.F., Ploeger, B.
openaire   +4 more sources

The Dynamic Transition of Persistence toward the Viable but Nonculturable State during Stationary Phase Is Driven by Protein Aggregation

mBio, 2021
Decades of research into bacterial persistence has been unable to fully characterize this antibiotic-tolerant phenotype, thereby hampering the development of therapies effective against chronic infections.
Liselot Dewachter, Celien Bollen, Dorien Wilmaerts, Elen Louwagie, Pauline Herpels, Paul Matthay, Ladan Khodaparast, Laleh Khodaparast, Frederic Rousseau, Joost Schymkowitz, Jan Michiels   +10 more
doaj   +1 more source

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia.

Cell Metabolism, 2006
Activation of glycolytic genes by HIF-1 is considered critical for metabolic adaptation to hypoxia through increased conversion of glucose to pyruvate and subsequently to lactate.
Jung-whan Kim, Irina Tchernyshyov, G. Semenza, C. Dang   +3 more
semanticscholar   +1 more source

A fast forecasting model of electrothermal distribution for parallelled SiC MOSFETs

Energy Reports, 2022
Parameter dispersion of SiC MOSFETs causes unbalanced current distribution in parallelled devices, which could increase voltage and current stresses of power devices, and lead to thermal imbalance between the devices, and thus affecting the working life ...
Haihong Qin, Haoxiang Hu, Ziyue Zhu, Qiang Xiu, Libiao Xie, Liming Hu   +5 more
doaj   +1 more source

Structural hot spots for the solubility of globular proteins

Nature Communications, 2016
Mutations in aggregation prone regions of recombinant proteins often improve their solubility, although they might cause negative effects on their structure and function.
Ashok Ganesan, Aleksandra Siekierska, Jacinte Beerten, Marijke Brams, Joost Van Durme, Greet De Baets, Rob Van der Kant, Rodrigo Gallardo, Meine Ramakers, Tobias Langenberg, Hannah Wilkinson, Frederik De Smet, Chris Ulens, Frederic Rousseau, Joost Schymkowitz   +14 more
doaj   +1 more source

Nucleosome Switches [PDF]

Physical Review Letters, 2008
We present a statistical-mechanical model for the positioning of nucleosomes along genomic DNA molecules as a function of the strength of the binding potential and the chemical potential of the nucleosomes. We show that a significant section of the DNA is composed of two-level nucleosome switching regions where the nucleosome distribution undergoes a ...
David J, Schwab, Robijn F, Bruinsma, Joseph, Rudnick, Jonathan, Widom   +3 more
openaire   +2 more sources

Indefinite Causal Order in a Quantum Switch. [PDF]

Physical Review Letters, 2018
Quantum mechanics allows events to happen with no definite causal order: this can be verified by measuring a causal witness, in the same way that an entanglement witness verifies entanglement.
K. Goswami, C. Giarmatzi, M. Kewming, Fabio Costa, Cyril Branciard, Jacquiline Romero, Andrew G. White   +6 more
semanticscholar   +1 more source